Browsing Bergen Open Research Archive by Author "Cox, Rebecca Jane"

Now showing items 41-60 of 64

    • Parenteral Vaccination against Influenza Does Not Induce a Local Antigen-Specific Immune Response in the Nasal Mucosa 

      Brokstad, Karl Albert; Eriksson, Jens-Christian Haug; Cox, Rebecca Jane; Tynning, Turid Liv; Olofsson, Jan; Jonsson, Roland; Davidsson, Åke (Peer reviewed; Journal article, 2002-03-19)
      The immune response in the nasal mucosa to influenza vaccination in 23 patients scheduled for tonsillectomy was studied. A statistically significant increase in influenza virus–specific serum and oral fluid antibodies was ...

    • The Performances of Three Commercially Available Assays for the Detection of SARS‐CoV‐2 Antibodies at Different Time Points Following SARS‐CoV‐2 Infection 

      Syre, Heidi; Obreque, Marius Eduardo Brå; Dalen, Ingvild; Riis, Åse Garløv; Berg, Åse; Löhr, Iren Høyland; Sundal, Jon; Kleppe, Lars Kåre Selland; Vadla, May Sissel; Lenning, Ole Bernt; Olofsson, Jan Stefan; Mohn, Kristin Greve-Isdahl; Tøndel, Camilla; Blomberg, Bjørn; Trieu, Mai Chi; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)
      The aim of this study was to evaluate the performances of three commercially available antibody assays for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies at different time points ...

    • Persistently high antibody responses after AS03-adjuvanted H1N1pdm09 vaccine: Dissecting the HA specific antibody response 

      Madsen, Anders; Jul-Larsen, Åsne; Trieu, Mai Chi; Krammer, Florian; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Current influenza vaccines have a suboptimal effectiveness. The introduction of a novel A/H1N1 influenza virus in 2009 (H1N1pdm09) provided a unique opportunity to study the humoral response to the AS03-adjuvanted H1N1pdm09 ...

    • Post COVID-19 condition after delta infection and omicron reinfection in children and adolescents 

      Ertesvåg, Nina Urke; Iversen, Arild; Blomberg, Bjørn; Özgümüs, Türküler; Rijal, Pramila; Fjelltveit, Elisabeth Berg; Cox, Rebecca Jane; Langeland, Nina; Haug, Kjell; Sandnes, Helene Heitmann; Mohn, Kristin Greve-Isdahl; Olofsson, Jan Stefan; Sævik, Marianne; Brokstad, Christopher James; Kuwelker, Kanika; Heienberg, Kristin (Journal article; Peer reviewed, 2023)
      Background: The burden of COVID-19 in children and adolescents has increased during the delta and omicron waves, necessitating studies of long-term symptoms such as fatigue, dyspnoea and cognitive problems. Furthermore, ...

    • Prolonging the delivery of influenza virus vaccine improves the quantity and quality of the induced immune responses in mice 

      Beukema, Martin; Gong, Shuran; Al-Jaawni, Kasem; de Vries-Idema, Jacqueline J.; Krammer, Florian; Zhou, Fan; Cox, Rebecca Jane; Huckriede, Anke (Journal article; Peer reviewed, 2023)
      Introduction: Influenza vaccines play a vital role in protecting individuals from influenza virus infection and severe illness. However, current influenza vaccines have suboptimal efficacy, which is further reduced in cases ...

    • Pulmonary changes in Norwegian fatal cases of pandemic influenza H1N1 (2009) infection: a morphologic and molecular genetic study 

      Voltersvik, Pål; Aqrawi, Lara Adnan; Dudman, Susanne Gjeruldsen; Hungnes, Olav; Bostad, Leif; Brokstad, Karl Albert; Cox, Rebecca Jane (Peer reviewed; Journal article, 2016-11)
      Background: During the pandemic outbreak of the 2009 swine influenza (A(H1N1) pdm09), 32 fatal cases occurred in Norway and 19 of these were included in this study. Objectives: We characterised pulmonary changes in these ...

    • Repeated Influenza Vaccination Boosts and Maintains H1N1pdm09 Neuraminidase Antibody Titers 

      Hansen, Lena; Zhou, Fan; Amdam, Håkon; Trieu, Mai Chi; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Antibodies to influenza surface protein neuraminidase (NA) have been found to reduce disease severity and may be an independent correlate of protection. Despite this, current influenza vaccines have no regulatory requirements ...

    • A Research and Development (R&D) roadmap for influenza vaccines: Looking toward the future 

      Moore, Kristine A.; Ostrowsky, Julia T.; Kraigsley, Alison M.; Mehr, Angela J.; Bresee, Joseph S.; Friede, Martin H.; Gellin, Bruce G.; Golding, Josephine P.; Hart, Peter J.; Moen, Ann; Weller, Charlotte L.; Osterholm, Michael T.; Ampofo, William; Barclay, Wendy; Cavaleri, Marco; Cohen, Cheryl; Cowling, Benjamin; Cox, Rebecca Jane; Gust, Ian; Innis, Bruce; Kang, Gagandeep; Katz, Jacqueline M.; Krammer, Florian; Pitisuttithum, Punnee; Post, Diane; Rudenko, Larisa; Siqueira, Marilda M.; Weir, Jerry P. (Journal article; Peer reviewed, 2021)
      Improved influenza vaccines are urgently needed to reduce the burden of seasonal influenza and to ensure a rapid and effective public-health response to future influenza pandemics. The Influenza Vaccines Research and ...

    • Responsiveness to influenza vaccination correlates with NKG2C-expression on NK cells 

      Riese, Peggy; Trittel, Stephanie; Pathirana, Rishi; Klawonn, Frank; Cox, Rebecca Jane; Guzmán, Carlos A. (Journal article; Peer reviewed, 2020-06-05)
      Influenza vaccination often results in a large percentage of low responders, especially in high-risk groups. As a first line of defense, natural killer (NK) cells play a crucial role in the fight against infections. However, ...

    • Risk assessment and antibody responses to SARS-CoV-2 in healthcare workers 

      Bansal, Amit; Trieu, Mai Chi; Mohn, Kristin Greve-Isdahl; Madsen, Anders; Olofsson, Jan Stefan; Sandnes, Helene Heitmann; Sævik, Marianne; Søyland, Hanne; Hansen, Lena; Onyango, Therese Bredholt; Tøndel, Camilla; Brokstad, Karl Albert; Syre, Heidi; Riis, Åse Garløv; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Background: Preventing infection in healthcare workers (HCWs) is crucial for protecting healthcare systems during the COVID-19 pandemic. Here, we investigated the seroepidemiology of SARS-CoV-2 in HCWs in Norway with ...

    • Safety, Immunogenicity, Efficacy and Effectiveness of Inactivated Influenza Vaccines in Healthy Pregnant Women and Children Under 5 Years: An Evidence-Based Clinical Review 

      Bansal, Amit; Trieu, Mai Chi; Mohn, Kristin Greve-Isdahl; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Annual influenza vaccination is often recommended for pregnant women and young children to reduce the risk of severe influenza. However, most studies investigating the safety, immunogenicity, and efficacy or effectiveness ...

    • SARS CoV-2 Infection among Health Care Workers from Different Health Care Facilities in Western Norway: A Prospective, Cross-Sectional Study 

      Kittang, Bård Reiakvam; Blomberg, Bjørn; Sævik, Marianne; Olofsson, Jan Stefan; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2022)
      Background: Comparative data on COVID-19 among health care workers (HCWs) in different health care settings are scarce. This study investigated the rates of previous COVID-19 among HCWs in nursing homes, hospitals and a ...

    • SARS-CoV-2 specific immune responses in overweight and obese COVID-19 patients 

      Onyango, Therese Bredholt; Zhou, Fan; Bredholt, Geir; Brokstad, Karl Albert; Jalloh, Sarah Larteley Lartey; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Kittang, Bård Reiakvam; Linchausen, Dagrun Waag; Shafiani, Shahin; Elyanow, Rebecca; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2023)
      Obesity is a known risk factor for severe respiratory tract infections. In this prospective study, we assessed the impact of being obese or overweight on longitudinal SARS-CoV-2 humoral and cellular responses up to 18 ...

    • SARS-CoV-2–Specific Neutralizing Antibody Responses in Norwegian Health Care Workers After the First Wave of COVID-19 Pandemic: A Prospective Cohort Study 

      Trieu, Mai Chi; Bansal, Amit; Madsen, Anders; Zhou, Fan; Sævik, Marianne; Vahokoski, Juha; Brokstad, Karl Albert; Krammer, Florian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Blomberg, Bjørn; Langeland, Nina; Cox, Rebecca Jane (Journal article; Peer reviewed, 2021)
      Background During the coronavirus disease 2019 (COVID-19) pandemic, many countries experienced infection in health care workers (HCW) due to overburdened health care systems. Whether infected HCW acquire protective immunity ...

    • Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses 

      Ertesvåg, Nina Urke; Cox, Rebecca Jane; Jalloh, Sarah Larteley Lartey; Mohn, Kristin Greve-Isdahl; Brokstad, Karl Albert; Trieu, Mai Chi (Journal article; Peer reviewed, 2022)
      History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied. We investigated the breadth and durability ...

    • Single dose vaccination of the ASO3-adjuvanted A (H1N1)pdm09 monovalent vaccine in health care workers elicits homologous and cross-reactive cellular and humoral responses to H1N1 strains 

      Jalloh, Sarah Larteley Lartey; Pathirana, Rishi; Zhou, Fan; Jul-Larsen, Åsne; Montomoli, Emanuele; Wood, John; Cox, Rebecca Jane (Peer reviewed; Journal article, 2015)
      Healthcare workers (HCW) were prioritized for vaccination during the 2009 influenza A(H1N1)pdm09 pandemic. We conducted a clinical trial in October 2009 where 237 HCWs were immunized with a AS03-adjuvanted A(H1N1)pdm09 ...

    • Symptom burden and immune dynamics 6 to 18 months following mild SARS-CoV-2 infection -a case-control study 

      Fjelltveit, Elisabeth Berg; Blomberg, Bjørn; Kuwelker, Kanika; Zhou, Fan; Onyango, Therese Bredholt; Brokstad, Karl Albert; Elyanow, Rebecca G; Kaplan, Ian; Tøndel, Camilla; Mohn, Kristin Greve-Isdahl; Özgümüs, Türküler; Cox, Rebecca Jane; Langeland, Nina (Journal article; Peer reviewed, 2022)
      Background The burden and duration of persistent symptoms after nonsevere coronavirus disease 2019 (COVID-19) remains uncertain. This study aimed to assess postinfection symptom trajectories in home-isolated COVID-19 cases ...

    • Titers of antibodies against ancestral SARS-CoV-2 correlate with levels of neutralizing antibodies to multiple variants 

      Tran, Trung The; Vaage, Eline Benno; Mehta, Adi; Chopra, Adity; Tietze, Lisa; Kolderup, Anette; Anthi, Aina Karen; König, Marton; Nygaard, Gro Owren; Lind, Andreas; Müller, Fredrik; Nissen-Meyer, Lise Sofie Haug; Magnus, Per Minor; Trogstad, Lill; Mjaaland, Siri; Søraas, Arne Vasli; Midtvedt, Karsten; Åsberg, Anders; Barratt-Due, Andreas; Medhus, Asle Wilhelm; Høivik, Marte Lie; Lundin, Knut; Karlsen, Randi Fuglaas; Dahle, Reidun; Danielsson, Karin; Thomassen, Kristine Stien; Kro, Grete Anette Birkeland; Cox, Rebecca Jane; Zhou, Fan; Langeland, Nina; Aukrust, Pål; Melum, Espen; Åvitsland, Tone Lise; Wiencke, Kristine; Holter, Jan Cato; Munthe, Ludvig Andre; Grødeland, Gunnveig; Andersen, Jan Terje; Vaage, John T.; Lund-Johansen, Fridtjof (Journal article; Peer reviewed, 2022)
      Diagnostic assays currently used to monitor the efficacy of COVID-19 vaccines measure levels of antibodies to the receptor-binding domain of ancestral SARS-CoV-2 (RBDwt). However, the predictive value for protection against ...

    • VACCELERATE Site Network: Real-time definition of clinical study capacity in Europe 

      Salmanton-García, Jon; Wipfler, Pauline; Valle-Simón, Paula; Merakou, Christina; Kopsidas, Ioannis; Bethe, Ullrich; Steinbach, Angela; Spivak, Orly; Součková, Lenka; Mendonça, Maria Amélia; Koniordou, Markela; Hellemans, Margot; Frías-Iniesta, Jesus; Davis, Ruth Joanna; Barta, Imre; Azzini, Anna Maria; Askling, Helena H.; Argyropoulos, Christos D.; Álvarez-Barco, Elena; Akova, Murat; Bonten, Marc M.J.; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Flisiak, Robert; Husa, Petr; Jancoriene, Ligita; Koscalova, Alena; Launay, Odile; Lundgren, Jens; Mallon, Patrick; Marques, Laura; Nauclér, Pontus; Ochando, Jordi; Pana, Zoi-Dorothea; Tacconelli, Evelina; Tóth, Krisztina; Trelle, Sven; van Damme, Pierre; Zaoutis, Theoklis E.; Zeitlinger, Markus; Albus, Kerstin; Stewart, Fiona A.; Hofstraat, Sanne H.I.; Bruijning-Verhagen, Patricia; Cornely, Oliver A. (Journal article; Peer reviewed, 2023)
      Background: The inconsistent European vaccine trial landscape rendered the continent of limited interest for vaccine developers. The VACCELERATE consortium created a network of capable clinical trial sites throughout Europe. ...

    • VACCELERATE Volunteer Registry: A European study participant database to facilitate clinical trial enrolment 

      Salmanton-García, Jon; Stewart, Fiona A.; Heringer, Sarah; Koniordou, Markela; Álvarez-Barco, Elena; Argyropoulos, Christos D.; Themistocleous, Sophia C.; Valle-Simón, Paula; Spivak, Orly; Součková, Lenka; Merakou, Christina; Amélia Mendonça, Maria; Joanna Davis, Ruth; Maria Azzini, Anna; Askling, Helena H.; Vene, Sirkka; Van Damme, Pierre; Steinbach, Angela; Shiamakkides, George; Seidel, Danila; Olesen, Ole F.; Noula, Evgenia; Macken, Alan; Luís, Catarina; Leckler, Janina; Launay, Odile; Isitt, Catherine; Hellemans, Margot; Frías-Iniesta, Jesús; Di Marzo, Romina; Carcas, Antonio J.; Boustras, George; Borobia, Alberto M.; Barta, Imre; Albus, Kerstin; Akova, Murat; Ochando, Jordi; Cohen-Kandli, Miriam; Cox, Rebecca Jane; Husa, Petr; Jancoriene, Ligita; Mallon, Patrick; Marques, Laura; Mellinghoff, Sibylle C.; Nauclér, Pontus; Tacconelli, Evelina; Tóth, Krisztina; Zaoutis, Theoklis E.; Zeitlinger, Markus; Cornely, Oliver A.; Pana, Zoi-Dorothea (Journal article; Peer reviewed, 2022)
      Introduction: The coronavirus disease 2019 (COVID-19) pandemic has evidenced the key role of vaccine design, obtention, production and administration to successfully fight against infectious diseases and to provide efficient ...