• Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome 

      van der Hoef, Camilla C.S.; Boorsma, Eva M.; Emmens, Johanna E.; van Essen, Bart J.; Metra, Marco; Ng, Leong L.; Anker, Stefan D.; Dickstein, Kenneth; Mordi, Ify R.; Dihoum, Adel; Lang, Chim C.; van Veldhuisen, Dirk J.; Lam, Carolyn S.P.; Voors, Adriaan A. (Journal article; Peer reviewed, 2023)
      Aim The comorbidities that collectively define metabolic syndrome are common in patients with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart failure is not well understood. We ...
    • Dipeptidyl peptidase 3, a marker of the antagonist pathway of the renin–angiotensin–aldosterone system in patients with heart failure 

      Boorsma, Eva M.; ter Maaten, Jozine M.; Damman, Kevin; van Veldhuisen, Dirk J.; Dickstein, Kenneth; Anker, Stefan D.; Filippatos, Gerasimos; Lang, Chim C.; Metra, Marco; Santos, Karine; Voors, Adriaan A. (Journal article; Peer reviewed, 2021)
      Aims Recently, dipeptidyl peptidase 3 (DPP3) has been discovered as the peptidase responsible for cleavage of angiotensin (1–7) [Ang (1–7)]. Ang (1–7) is part of the angiotensin-converting enzyme–Ang (1–7)–Mas pathway ...