• Brain solute transport is more rapid in periarterial than perivenous spaces 

      Vinje, Vegard; Bakker, Erik N. T. P.; Rognes, Marie Elisabeth (Journal article; Peer reviewed, 2021)
      Fluid flow in perivascular spaces is recognized as a key component underlying brain transport and clearance. An important open question is how and to what extent differences in vessel type or geometry affect perivascular ...
    • CSF circulation and dispersion yield rapid clearance from intracranial compartments 

      Hornkjøl, Martin; Valnes, Lars Magnus; Ringstad, Geir; Rognes, Marie Elisabeth; Eide, Per Kristian; Mardal, Kent-Andre; Vinje, Vegard (Journal article; Peer reviewed, 2022-09-12)
      In this paper, we used a computational model to estimate the clearance of a tracer driven by the circulation of cerebrospinal fluid (CSF) produced in the choroid plexus (CP) located within the lateral ventricles. CSF was ...
    • Geometrically Reduced Modelling of Pulsatile Flow in Perivascular Networks 

      Daversin-Catty, Cécile; Gjerde, Ingeborg Gåseby; Rognes, Marie Elisabeth (Journal article; Peer reviewed, 2022)
      Flow of cerebrospinal fluid in perivascular spaces is a key mechanism underlying brain transport and clearance. In this paper, we present a mathematical and numerical formalism for reduced models of pulsatile viscous fluid ...
    • Human intracranial pulsatility during the cardiac cycle: a computational modelling framework 

      Causemann, Marius; Vinje, Vegard; Rognes, Marie Elisabeth (Journal article; Peer reviewed, 2022)
      Background Today’s availability of medical imaging and computational resources set the scene for high-fidelity computational modelling of brain biomechanics. The brain and its environment feature a dynamic and complex ...
    • A posteriori error estimation and adaptivity for multiple-network poroelasticity 

      Ødegaard, Emilie Eliseussen; Rognes, Marie Elisabeth; Thompson, Travis B. (Journal article; Peer reviewed, 2023)
      The multiple-network poroelasticity (MPET) equations describe deformation and pressures in an elastic medium permeated by interacting fluid networks. In this paper, we (i) place these equations in the theoretical context ...
    • Validating a Computational Framework for Ionic Electrodiffusion with Cortical Spreading Depression as a Case Study 

      Ellingsrud, Ada Johanne; Dukefoss, Didrik Bakke; Enger, Rune; Halnes, Geir; Pettersen, Klas Henning; Rognes, Marie Elisabeth (Journal article; Peer reviewed, 2022)
      Cortical spreading depression (CSD) is a wave of pronounced depolarization of brain tissue accompanied by substantial shifts in ionic concentrations and cellular swelling. Here, we validate a computational framework for ...