dc.contributor.author | Schem, Baard-Christian | |
dc.contributor.author | Pfeffer, Frank | |
dc.contributor.author | Ott, Martin Anton | |
dc.contributor.author | Wiig, Johan N. | |
dc.contributor.author | Sletteskog, Nils | |
dc.contributor.author | Frøystein, Torbjørn | |
dc.contributor.author | Myklebust, Mette Pernille | |
dc.contributor.author | Leh, Sabine | |
dc.contributor.author | Dahl, Olav | |
dc.contributor.author | Mella, Olav | |
dc.date.accessioned | 2022-08-15T08:24:56Z | |
dc.date.available | 2022-08-15T08:24:56Z | |
dc.date.created | 2022-05-12T13:57:31Z | |
dc.date.issued | 2022-01-29 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | https://hdl.handle.net/11250/3011783 | |
dc.description.abstract | Hyperthermia was added to standard preoperative chemoradiation for rectal adenocarcinomas in a phase II study. Patients with T3-4 N0-2 M0 rectal cancer or local recurrences were included. Radiation dose was 54 Gy combined with capecitabine 825 mg/m2 × 2 daily and once weekly oxaliplatin 55 mg/m2. Regional hyperthermia aimed at 41.5–42.5 °C for 60 min combined with oxaliplatin infusion. Radical surgery with total or extended TME technique, was scheduled at 6–8 weeks after radiation. From April 2003 to April 2008, a total of 49 eligible patients were recruited. Median number of hyperthermia sessions were 5.4. A total of 47 out of 49 patients (96%) had the scheduled surgery, which was clinically radical in 44 patients. Complete tumour regression occurred in 29.8% of the patients who also exhibited statistically significantly better RFS and CSS. Rate of local recurrence alone at 10 years was 9.1%, distant metastases alone occurred in 25.6%, including local recurrences 40.4%. RFS for all patients was 54.8% after 5 years and CSS was 73.5%. Patients with T50 temperatures in tumours above median 39.9 °C had better RFS, 66.7% vs. 31.3%, p = 0.047, indicating a role of hyperthermia. Toxicity was acceptable. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Long-Term Outcome in a Phase II Study of Regional Hyperthermia Added to Preoperative Radiochemotherapy in Locally Advanced and Recurrent Rectal Adenocarcinomas | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 the authors | en_US |
dc.source.articlenumber | 705 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.3390/cancers14030705 | |
dc.identifier.cristin | 2023960 | |
dc.source.journal | Cancers | en_US |
dc.identifier.citation | Cancers. 2022, 14 (3), 705. | en_US |
dc.source.volume | 14 | en_US |
dc.source.issue | 3 | en_US |