dc.contributor.author | Lopez-Doriga Ruiz, Paz | |
dc.contributor.author | Gunnes, Nina | |
dc.contributor.author | Gran, Jon Michael | |
dc.contributor.author | Karlstad, Øystein | |
dc.contributor.author | Selmer, Randi Marie | |
dc.contributor.author | Dahl, Jesper | |
dc.contributor.author | Bøås, Håkon | |
dc.contributor.author | White, Richard Aubrey | |
dc.contributor.author | Hofman, Aurora Christine | |
dc.contributor.author | Paulsen, Trine Hessevik | |
dc.contributor.author | Watle, Sara Sofie Viksmoen | |
dc.contributor.author | Ranhoff, Anette Hylen | |
dc.contributor.author | Bukholm, Geir | |
dc.contributor.author | Gulseth, Hanne Løvdal | |
dc.contributor.author | Tapia, German | |
dc.date.accessioned | 2023-01-20T12:46:39Z | |
dc.date.available | 2023-01-20T12:46:39Z | |
dc.date.created | 2022-11-14T12:53:46Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 0264-410X | |
dc.identifier.uri | https://hdl.handle.net/11250/3044952 | |
dc.description.abstract | Background
There have been concerns about COVID-19 vaccination safety among frail older individuals. We investigated the relationship between COVID-19 mRNA vaccination and mortality among individuals aged ≥ 70 years and whether mortality varies across four groups of health services used.
Methods
In this nationwide cohort study, we included 688,152 individuals aged ≥ 70 years at the start of the Norwegian vaccination campaign (December 27, 2020). We collected individual-level data from the Norwegian Emergency Preparedness Register for COVID-19. Vaccinated and unvaccinated individuals were matched (1:1 ratio) on the date of vaccination based on sociodemographic and clinical characteristics. The main outcome was all-cause mortality during 21 days after first dose of COVID-19 mRNA vaccination. Kaplan-Meier survival functions were estimated for the vaccinated and unvaccinated groups. We used Cox proportional-hazards regression to estimate hazard ratios (HRs) of death between vaccinated and unvaccinated individuals, with associated 95% confidence intervals (CIs), overall and by use of health services (none, home-based, short- and long-term nursing homes) and age group.
Results
Between December 27, 2020, and March 31, 2021, 420,771 older individuals (61.1%) were vaccinated against COVID-19. The Kaplan-Meier estimates based on the matched study sample showed a small absolute risk difference in all-cause mortality between vaccinated and unvaccinated individuals, with a lower mortality in the vaccinated group (overall HR 0.28 [95% CI: 0.24–0.31]). Similar results were obtained in analyses stratified by use of health services and age group.
Conclusion
We found no evidence of increased short-term mortality among vaccinated individuals in the older population after matching on sociodemographic and clinical characteristics affecting vaccination and mortality. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | Navngivelse 4.0 Internasjonal | * |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/deed.no | * |
dc.title | Short-term safety of COVID-19 mRNA vaccines with respect to all-cause mortality in the older population in Norway | en_US |
dc.type | Journal article | en_US |
dc.type | Peer reviewed | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2022 The Author(s) | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |
dc.identifier.doi | 10.1016/j.vaccine.2022.10.085 | |
dc.identifier.cristin | 2073486 | |
dc.source.journal | Vaccine | en_US |
dc.source.pagenumber | 323-332 | en_US |
dc.identifier.citation | Vaccine. 2022, 41 (2), 323-332. | en_US |
dc.source.volume | 41 | en_US |
dc.source.issue | 2 | en_US |