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dc.contributor.authorØstbye, Tone-Kari K
dc.contributor.authorGudbrandsen, Oddrun Anita
dc.contributor.authorDrotningsvik, Aslaug
dc.contributor.authorRuyter, Bente Synnøve
dc.contributor.authorBerge, Gerd Marit
dc.contributor.authorVogt, Kjell Gjermund
dc.contributor.authorNilsson, Astrid
dc.date.accessioned2023-06-19T09:32:29Z
dc.date.available2023-06-19T09:32:29Z
dc.date.created2023-06-13T17:53:25Z
dc.date.issued2023-05-17
dc.identifier.issn2072-6643
dc.identifier.urihttps://hdl.handle.net/11250/3072019
dc.description.abstractPlant-based food provides more ALA (α-linolenic acid) and less EPA (eicosapentaenoic acid) and DHA (docosahexanoic acid) than marine food. Earlier studies indicate that cetoleic acid (22:1n-11) stimulates the n-3 pathway from ALA to EPA and DHA. The present study aimed to investigate the dietary effects of camelina oil (CA) high in ALA and sandeel oil (SA) high in cetoleic acid on the conversion of ALA to EPA and DHA. Male Zucker fa/fa rats were fed a diet of soybean oil (Ctrl) or diets of CA, SA, or a combination of CA and SA. Significantly higher levels of DPA (docosapentaenoic acid) and DHA in blood cells from the CA group compared to the Ctrl indicate an active conversion of ALA to DPA and DHA. Increasing the uptake and deposition of EPA and DHA meant that a trend towards a decrease in the liver gene expression of Elovl5, Fads1, and Fads2 along with an increase in the dietary content of SA was observed. However, 25% of the SA could be exchanged with CA without having a significant effect on EPA, DPA, or DHA in blood cells, indicating that bioactive components in SA, such as cetoleic acid, might counteract the inhibiting effect of the high dietary content of DHA on the n-3 biosynthetic pathway.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.titleDifferent Dietary Ratios of Camelina Oil to Sandeel Oil Influence the Capacity to Synthesise and Deposit EPA and DHA in Zucker Fa/Fa Ratsen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2023 the authorsen_US
dc.source.articlenumber2344en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1
dc.identifier.doi10.3390/nu15102344
dc.identifier.cristin2154255
dc.source.journalNutrientsen_US
dc.identifier.citationNutrients. 2023, 15 (10), 2344.en_US
dc.source.volume15en_US
dc.source.issue10en_US


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Navngivelse 4.0 Internasjonal
Except where otherwise noted, this item's license is described as Navngivelse 4.0 Internasjonal