dc.contributor.author | Pearson, Leanne | |
dc.contributor.author | Mihali, Troco K. | |
dc.contributor.author | Moffitt, Michelle | |
dc.contributor.author | Kellmann, Ralf | |
dc.contributor.author | Neilan, Brett A. | |
dc.date.accessioned | 2016-08-09T09:09:13Z | |
dc.date.available | 2016-08-09T09:09:13Z | |
dc.date.issued | 2010-05-10 | |
dc.Published | Marine Drugs 2010, 8(5):1650-1680 | eng |
dc.identifier.issn | 1660-3397 | en_US |
dc.identifier.uri | https://hdl.handle.net/1956/12506 | |
dc.description.abstract | The cyanobacteria or “blue-green algae”, as they are commonly termed, comprise a diverse group of oxygenic photosynthetic bacteria that inhabit a wide range of aquatic and terrestrial environments, and display incredible morphological diversity. Many aquatic, bloom-forming species of cyanobacteria are capable of producing biologically active secondary metabolites, which are highly toxic to humans and other animals. From a toxicological viewpoint, the cyanotoxins span four major classes: the neurotoxins, hepatotoxins, cytotoxins, and dermatoxins (irritant toxins). However, structurally they are quite diverse. Over the past decade, the biosynthesis pathways of the four major cyanotoxins: microcystin, nodularin, saxitoxin and cylindrospermopsin, have been genetically and biochemically elucidated. This review provides an overview of these biosynthesis pathways and additionally summarizes the chemistry and toxicology of these remarkable secondary metabolites. | en_US |
dc.language.iso | eng | eng |
dc.publisher | MDPI | en_US |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | eng |
dc.subject | cyanotoxin | eng |
dc.subject | non-ribosomal peptide | eng |
dc.subject | polyketide | eng |
dc.subject | alkaloid | eng |
dc.subject | toxicology | eng |
dc.title | On the chemistry, toxicology and genetics of the cyanobacterial toxins, microcystin, nodularin, saxitoxin and cylindrospermopsin | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2016-04-08T11:15:17Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2010 by the authors | en_US |
dc.identifier.doi | https://doi.org/10.3390/md8051650 | |
dc.identifier.cristin | 348795 | |
dc.subject.nsi | VDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Biokjemi: 476 | |
dc.subject.nsi | VDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Biochemistry: 476 | |
dc.subject.nsi | VDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Molekylærbiologi: 473 | |
dc.subject.nsi | VDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Molecular biology: 473 | |