dc.contributor.author | Mäki-Marttunen, Tuomo | en_US |
dc.contributor.author | Krull, Florian | en_US |
dc.contributor.author | Bettella, Francesco | en_US |
dc.contributor.author | Hagen, Espen | en_US |
dc.contributor.author | Næss, Solveig | en_US |
dc.contributor.author | Ness, Torbjørn V | en_US |
dc.contributor.author | Moberget, Torgeir | en_US |
dc.contributor.author | Elvsåshagen, Torbjørn | en_US |
dc.contributor.author | Metzner, Christoph | en_US |
dc.contributor.author | Devor, Anna | en_US |
dc.contributor.author | Edwards, Andrew G. | en_US |
dc.contributor.author | Fyhn, Marianne | en_US |
dc.contributor.author | Djurovic, Srdjan | en_US |
dc.contributor.author | Dale, Anders | en_US |
dc.contributor.author | Andreassen, Ole Andreas | en_US |
dc.contributor.author | Einevoll, Gaute | en_US |
dc.date.accessioned | 2020-05-13T09:18:21Z | |
dc.date.available | 2020-05-13T09:18:21Z | |
dc.date.issued | 2019-02 | |
dc.Published | Mäki-Marttunen T, Krull F, Bettella F, Hagen E, Næss S, et al. Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations. Cerebral Cortex. 2019;29(2):875-891 | eng |
dc.identifier.issn | 1047-3211 | |
dc.identifier.issn | 1460-2199 | |
dc.identifier.uri | https://hdl.handle.net/1956/22219 | |
dc.description.abstract | Genome-wide association studies have implicated many ion channels in schizophrenia pathophysiology. Although the functions of these channels are relatively well characterized by single-cell studies, the contributions of common variation in these channels to neurophysiological biomarkers and symptoms of schizophrenia remain elusive. Here, using computational modeling, we show that a common biomarker of schizophrenia, namely, an increase in delta-oscillation power, may be a direct consequence of altered expression or kinetics of voltage-gated ion channels or calcium transporters. Our model of a circuit of layer V pyramidal cells highlights multiple types of schizophrenia-related variants that contribute to altered dynamics in the delta-frequency band. Moreover, our model predicts that the same membrane mechanisms that increase the layer V pyramidal cell network gain and response to delta-frequency oscillations may also cause a deficit in a single-cell correlate of the prepulse inhibition, which is a behavioral biomarker highly associated with schizophrenia. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Oxford University Press | eng |
dc.rights | Attribution-NonCommercial CC BY-NC | eng |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | eng |
dc.subject | forward modeling of EEG | eng |
dc.subject | functional genomics | eng |
dc.subject | ion channels | eng |
dc.subject | multicompartmental neuron modeling | eng |
dc.subject | schizophrenia genetics | eng |
dc.title | Alterations in schizophrenia-associated genes can lead to increased power in delta oscillations | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2020-01-21T13:41:39Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2018 The Author(s) | |
dc.identifier.doi | https://doi.org/10.1093/cercor/bhy291 | |
dc.identifier.cristin | 1696402 | |
dc.source.journal | Cerebral Cortex | |