dc.contributor.author | Fredriksen, Mats | en_US |
dc.contributor.author | Egeland, Jens | en_US |
dc.contributor.author | Haavik, Jan | en_US |
dc.contributor.author | Fasmer, Ole Bernt | en_US |
dc.date.accessioned | 2020-08-11T13:12:22Z | |
dc.date.available | 2020-08-11T13:12:22Z | |
dc.date.issued | 2019 | |
dc.Published | Fredriksen M, Egeland J, Haavik J, Fasmer OB. Individual Variability in Reaction Time and Prediction of Clinical Response to Methylphenidate in Adult ADHD: A Prospective Open Label Study Using Conners’ Continuous Performance Test II. Journal of Attention Disorders. 2019 | eng |
dc.identifier.issn | 1087-0547 | |
dc.identifier.issn | 1557-1246 | |
dc.identifier.uri | https://hdl.handle.net/1956/23659 | |
dc.description.abstract | Objective: The aim of this study was to examine whether reaction time parameters in adult patients with ADHD could predict their response to methylphenidate (MPH). Method: Previously unmedicated patients (N = 123) were administered the Conners’ Continuous Performance Test II (CPT II) at baseline and after 6 weeks of treatment with immediate-release MPH. In addition to traditional CPT measures, we extracted intraindividual raw data and analyzed time series using linear and nonlinear mathematical models. Results: Clinical responders, assessed with the Clinical Global Impression-Improvement scale, showed significant normalization of target failures, reduced variability and skewness, and increased complexity of reaction time series after 6 weeks of treatment, while nonresponders showed no significant changes. Prior to treatment, responders had significantly higher variability and skewness, combined with lower complexity, compared with nonresponders. Conclusion: These results show that the CPT test is useful in the evaluation of treatment response to MPH. | en_US |
dc.language.iso | eng | eng |
dc.publisher | SAGE | eng |
dc.title | Individual Variability in Reaction Time and Prediction of Clinical Response to Methylphenidate in Adult ADHD: A Prospective Open Label Study Using Conners’ Continuous Performance Test II | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2020-01-29T13:11:35Z | |
dc.description.version | acceptedVersion | en_US |
dc.rights.holder | Copyright 2019 The Authors | |
dc.identifier.doi | https://doi.org/10.1177/1087054719829822 | |
dc.identifier.cristin | 1678112 | |
dc.source.journal | Journal of Attention Disorders | |