Blar i Department of Clinical Science på tidsskrift "Nature Communications"

Viser treff 21-30 av 30

    • Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex 

      Wilson, Madison N.; Thunemann, Martin; Liu, Xin; Lu, Yichen; Puppo, Francesca; Adams, Jason W.; Kim, Jeong-Hoon; Ramezani, Mehrdad; Pizzo, Donald P.; Djurovic, Srdjan; Andreassen, Ole; Mansour, Abed AlFatah; Gage, Fred H.; Muotri, Alysson R.; Devor, Anna; Kuzum, Duygu (Journal article; Peer reviewed, 2022)
      Human cortical organoids, three-dimensional neuronal cultures, are emerging as powerful tools to study brain development and dysfunction. However, whether organoids can functionally connect to a sensory network in vivo has ...

    • Obesity-associated changes in molecular biology of primary breast cancer 

      Nguyen, Ha-Linh; Geukens, Tatjana; Maetens, Marion; Aparicio, Samuel; Bassez, Ayse; Borg, Ake; Brock, Jane; Broeks, Annegien; Caldas, Carlos; Cardoso, Fatima; De Schepper, Maxim; Delorenzi, Mauro; Drukker, Caroline A.; Glas, Annuska M.; Green, Andrew R.; Isnaldi, Edoardo; Eyfjörð, Jórunn; Khout, Hazem; Knappskog, Stian; Krishnamurthy, Savitri; Lakhani, Sunil R.; Langerød, Anita; Martens, John W. M.; McCart Reed, Amy E.; Murphy, Leigh; Naulaerts, Stefan; Nik-Zainal, Serena; Nevelsteen, Ines; Neven, Patrick; Piccart, Martine; Poncet, Coralie; Punie, Kevin; Purdie, Colin; Rakha, Emad A.; Richardson, Andrea; Rutgers, Emiel; Vincent-Salomon, Anne; Simpson, Peter T.; Schmidt, Marjanka K.; Sotiriou, Christos; Span, Paul N.; Tan, Kiat Tee Benita; Thompson, Alastair; Tommasi, Stefania; Van Baelen, Karen; Van de Vijver, Marc; Van Laere, Steven; van’t Veer, Laura; Viale, Giuseppe; Viari, Alain; Vos, Hanne; Witteveen, Anke T.; Wildiers, Hans; Floris, Giuseppe; Garg, Abhishek D.; Smeets, Ann; Lambrechts, Diether; Biganzoli, Elia; Richard, François; Desmedt, Christine (Journal article; Peer reviewed, 2023)
      Obesity is associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet its impact on BC biology remains understudied in humans. This study investigates how the biology of ...

    • Patterns of genomic evolution in advanced melanoma 

      Birkeland, Einar Elvbakken; Zhang, Shan; Poduval, Deepak; Geisler, Jürgen; Nakken, Sigve; Vodak, Daniel; Meza, Leonardo Zepeda; Hovig, Eivind; Myklebost, Ola; Knappskog, Stian; Lønning, Per Eystein (Peer reviewed; Journal article, 2018-07-10)
      Genomic alterations occurring during melanoma progression and the resulting genomic heterogeneity between metastatic deposits remain incompletely understood. Analyzing 86 metastatic melanoma deposits from 53 patients with ...

    • A proteomics sample metadata representation for multiomics integration and big data analysis 

      Dai, Chengxin; Füllgrabe, Anja; Pfeuffer, Julianus; Solovyeva, Elizaveta M.; Deng, Jingwen; Moreno, Pablo; Kamatchinathan, Selvakumar; Kundu, Deepti Jaiswal; George, Nancy; Fexova, Silvie; Grüning, Björn A.; Föll, Melanie Christine; Griss, Johannes; Vaudel, Marc; Audain, Enrique; Locard-Paulet, Marie; Turewicz, Michael; Eisenacher, Martin; Uszkoreit, Julian; Van Den Bossche, Tim; Schwämmle, Veit; Webel, Henry; Schulze, Stefan; Bouyssié, David; Jayaram, Savita; Duggineni, Vinay Kumar; Samaras, Patroklos; Wilhelm, Mathias; Choi, Meena; Wang, Mingxun; Kohlbacher, Oliver; Brazma, Alvis; Papatheodorou, Irene; Bandeira, Nuno; Deutsch, Eric W.; Vizcaíno, Juan Antonio; Bai, Mingze; Sachsenberg, Timo; Levitsky, Lev I.; Perez-Riverol, Yasset (Journal article; Peer reviewed, 2021)
      The amount of public proteomics data is rapidly increasing but there is no standardized format to describe the sample metadata and their relationship with the dataset files in a way that fully supports their understanding ...

    • Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples 

      Bailey, Matthew H.; Meyerson, William U.; Dursi, L. Jonathan; Wang, Liang-Bo; Dong, Guanlan; Liang, Wen-Wei; Weerasinghe, Amila; Li, Shantao; Li, Yize; Kelso, Sean; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Akbani, Rehan; Anur, Pavana; Buchanan, Alex; Chiotti, Kami; Covington, Kyle; Creason, Allison; Niu, Beifang; Bieg, Matthias; Boutros, Paul C.; Buchhalter, Ivo; Butler, Adam P.; Chen, Ken; Chong, Zechen; Drechsel, Oliver; Aaltonen, Lauri; Abascal, Federico; Abeshouse, Adam; Aburatani, H; Adams, David J.; Van Loo, Peter; Saksena, Gordon; Ellrott, Kyle; Wendl, Michael C.; Wheeler, David A.; Getz, Gad; Simpson, Jared T.; Gerstein, Mark B.; Ding, Li (Journal article; Peer reviewed, 2020)
      The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part ...

    • Sex differences in oncogenic mutational processes 

      Li, Constance H.; Prokopec, Stephenie D.; Sun, Ren X.; Yousif, Fouad; Schmitz, Nathaniel; Boutros, Paul C.; Aure, Miriam Ragle; Børresen-Dale, Anne-Lise; Langerød, Anita; Wright, Derek W.; Baumhoer, Daniel; Bjerkehagen, Bodil; Garred, Øystein; Lingjærde, Ole Christian; Sauer, Torill; Zaikova, Olga; Myklebost, Ola; Knappskog, Stian; Vazquez, Miguel; Van Loo, Peter (Journal article; Peer reviewed, 2020)
      Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features ...

    • Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability 

      Lagou, Vasiliki; Mägi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis V.; Jansen, Rick; Min, JL; Dimas, AS; Ulrich, Anna; Zudina, Liudmila; Gådin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amélie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron; Willems, Sara M.; Navarro, Pau; Tanaka, Toshiko; Jackson, Anne U.; Montasser, May E.; O’Connell, Jeff R.; Bielak, Lawrence F.; Webster, Rebecca J.; Saxena, Richa; Stafford, Jeanette M.; Pourcain, Beate St; Timpson, Nicholas J.; Salo, Perttu; Shin, SY; Amin, Najaf; Smith, Albert V.; Li, G; Verweij, Niek; Goel, Anuj; Ford, Ian; Johnson, Paul C. D.; Johnson, Toby; Kapur, Karen; Thorleifsson, Gudmar; Strawbridge, Rona J.; Rasmussen-Torvik, Laura J.; Esko, Tõnu; Mihailov, E; Fall, Tove; Fraser, Ross M; Mahajan, Anubha; Kanoni, Stavroula; Giedraitis, Vilmantas; Kleber, Marcus E.; Silbernagel, Günther; Meyer, Julia; Müller-Nurasyid, Martina; Ganna, Andrea; Sarin, Antti-Pekka; Yengo, Loic; Shungin, D; Luan, Jian’an; Horikoshi, Momoko; An, Ping; Sanna, Serena; Boettcher, Yvonne; Rayner, Nigel W; Nolte, Ilja M.; Zemunik, Tatijana; Iperen, Erik van; Kovacs, Peter; Hastie, Nicholas D.; Wild, Sarah H.; McLachlan, Stela; Campbell, Susan; Polasek, Ozren; Carlson, Olga; Egan, Josephine; Kiess, Wieland; Willemsen, Gonneke; Kuusisto, Johanna; Laakso, Markku; Dimitriou, M; Hicks, Andrew A.; Rauramaa, Rainer; Bandinelli, Stefania; Thorand, Barbara; Liu, Yongmei; Miljkovic, Iva; Lind, Lars; Doney, Alex; Perola, Markus; Hingorani, Aroon; Kivimaki, Mika; Kumari, Meena; Bennett, Amanda J.; Groves, Christopher J.; Herder, Christian; Koistinen, Heikki A.; Kinnunen, Leena; Faire, Ulf de; Bakker, Stephan J. L.; Uusitupa, Matti; Palmer, Colin N. A.; Jukema, J. Wouter; Sattar, Naveed; Pouta, Anneli; Snieder, Harold; Boerwinkle, Eric; Pankow, James S.; Magnusson, Patrik K.; Krus, Ulrika; Scapoli, Chiara; de Geus, Eco J. C. N.; Blüher, Matthias; Wolffenbuttel, Bruce H. R.; Province, Michael A.; Abecasis, Goncalo R.; Meigs, James B.; Hovingh, G. Kees; Lindström, Jaana; Wilson, JF; Wright, Alan F.; Dedoussis, George; Bornstein, Stefan R.; Schwarz, Peter E. H.; Tönjes, Anke; Winkelmann, Bernhard R.; Boehm, Bernhard O.; März, Winfried; Metspalu, Andres; Price, Jackie F.; Deloukas, Panos; Körner, Antje; Lakka, Timo A.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Bergman, Richard N.; Tuomilehto, Jaakko; Wareham, Nick; Langenberg, Claudia; Männistö, Satu; Franks, Paul W; Hayward, Caroline; Vitart, Veronique; Kaprio, Jaakko; Visvikis-Siest, Sophie; Balkau, Beverley; Altshuler, D; Rudan, Igor; Stumvoll, Michael; Campbell, Harry; van Duijn, Cornelia M.; Gieger, Christian; Illig, Thomas; Ferrucci, Luigi; Pedersen, Nancy L.; Pramstaller, Peter P.; Boehnke, Michael; Frayling, TM; Shuldiner, Alan R.; Peyser, Patricia A.; Kardia, Sharon L. R.; Palmer, Lyle J.; Penninx, Brenda W.; Meneton, Pierre; Harris, Tamara B.; Navis, Gerjan; Harst, Pim van der; Smith, George Davey; Forouhi, Nita G.; Loos, Ruth J. F.; Salomaa, Veikko; Soranzo, Nicole; Boomsma, Dorret I.; Groop, L; Tuomi, Tiinamaija; Hofman, Albert; Munroe, Patricia B.; Gudnason, Vilmundur; Siscovick, David S.; Watkins, Hugh; Lecoeur, Cecile; Vollenweider, Peter; Franco-Cereceda, Anders; Eriksson, Per; Jarvelin, Marjo-Riitta; Stefansson, Kari; Hamsten, Anders; Nicholson, George; Karpe, Fredrik; Dermitzakis, Emmanouil T.; Lindgren, Cecilia M.; McCarthy, Mark I.; Froguel, Philippe; Kaakinen, Marika A.; Lyssenko, Valeriya; Watanabe, Richard M.; Ingelsson, Erik; Florez, Jose C.; Dupuis, Josée; Barroso, I; Morris, Andrew P.; Prokopenko, Inga (Journal article; Peer reviewed, 2021)
      Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in ...

    • Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function 

      Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C.M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L.K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; Derosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Smith, Jennifer A.; Smith, Albert V.; Terzikhan, Natalie; Thalamuthu, Anbupalam; Trompet, Stella; van der Lee, Sven J.; Ware, Erin B.; Windham, B. Gwen; Wright, Margaret J.; Yang, Jingyun; Yu, Jin; Ames, David; Amin, Najaf; Amouyel, Philippe; Andreassen, Ole Andreas; Armstrong, Nicola J.; Assareh, Amelia A; Attia, John R.; Attix, Deborah; Avramopoulos, Dimitrios; Bennett, David A.; Böhmer, Anne C.; Boyle, Patricia A.; Brodaty, Henry; Campbell, Harry; Cannon, Tyrone D.; Cirulli, Elizabeth T.; Congdon, Eliza; Conley, Emily Drabant; Corley, Janie; Cox, Simon R.; Dale, Anders; Dehghan, Abbas; Dick, Danielle; Dickinson, Dwight; Eriksson, Johan G.; Evangelou, Evangelos; Faul, Jessica D.; Ford, Ian; Freimer, Nelson A.; Gao, He; Giegling, Ina; Gillespie, Nathan A.; Gordon, Scott D.; Gottesman, Rebecca F.; Griswold, Michael E.; Gudnason, Vilmundur; Harris, Tamara B.; Hartmann, Annette M.; Hatzimanolis, Alex; Heiss, Gerardo; Holliday, Elizabeth G.; Joshi, Peter K.; Kähönen, Mika; Kardia, Sharon L.R.; Karlsson, Ida; Kleineidam, Luca; Knopman, David S.; Kochan, Nicole A.; Konte, Bettina; Kwok, John B.; Le Hellard, Stephanie; Lee, Teresa; Lehtimäki, Terho; Li, Shu-Chen; Liu, Tian; Koini, Marisa; London, Edythe; Longstreth, Will T.; Lopez, Oscar L.; Loukola, Anu; Luck, Tobias; Lundervold, Astri; Lundquist, Anders; Lyytikäinen, Leo-Pekka; Martin, Nicholas G.; Montgomery, Grant W.; Murray, Alison D.; Need, Anna C.; Noordam, Raymond; Nyberg, Lars; Ollier, William; Papenberg, Göran; Pattie, Alison; Polasek, Ozren; Poldrack, Russell A.; Psaty, Bruce M.; Reppermund, Simone; Riedel-Heller, Steffi G.; Rose, Richard J.; Rotter, Jerome I.; Roussos, Panos; Rovio, Suvi P.; Saba, Yasaman; Sabb, Fred W.; Sachdev, Perminder S.; Satizabal, Claudia L.; Schmid, Matthias; Scott, Rodney J.; Scult, Matthew A.; Simino, Jeannette; Slagboom, P. Eline; Smyrnis, Nikolaos; Soumaré, Aïcha; Stefanis, Nikos C.; Stott, David J.; Straub, Richard E.; Sundet, Kjetil Søren; Taylor, Adele M.; Taylor, Kent D.; Tzoulaki, Ioanna; Tzourio, Christophe; Uitterlinden, André; Vitart, Veronique; Voineskos, Aristotle N.; Kaprio, Jaakko; Wagner, Michael; Wagner, Holger; Weinhold, Leonie; Wen, K. Hoyan; Widén, Elisabeth; Yang, Qiong; Zhao, Wei; Adams, Hieab H.H.; Arking, Dan E.; Bilder, Robert M.; Bitsios, Panos; Boerwinkle, Eric; Chiba-Falek, Ornit; Corvin, Aiden; De Jager, Philip L.; Debette, Stéphanie; Donohoe, Gary; Elliott, Paul; Fitzpatrick, Annette L.; Gill, Michael; Glahn, David C.; Hägg, Sara; Hansell, Narelle K.; Hariri, Ahmad; Ikram, M. Kamran; Jukema, J. Wouter; Vuoksimaa, Eero; Keller, Matthew C.; Kremen, William S.; Launer, Lenore; Lindenberger, Ulman; Palotie, Aarno; Pedersen, Nancy L.; Pendleton, Neil; Porteous, David J.; Räikkönen, Katri; Raitakari, Olli T.; Ramirez, Alfredo; Reinvang, Ivar; Rudan, Igor; Rujescu, Dan; Schmidt, Reinhold; Schmidt, Helena; Schofield, Peter W.; Schofield, Peter R.; Starr, John M.; Steen, Vidar Martin; Trollor, Julian N.; Turner, Steven T.; Van Duijn, Cornelia M.; Villringer, Arno; Weinberger, Daniel R.; Weir, David R.; Wilson, James F.; Malhotra, Anil; McIntosh, Andrew M.; Gale, Catharine R.; Seshadri, Sudha; Mosley, Thomas H.; Bressler, Jan; Lencz, Todd; Deary, Ian J. (Peer reviewed; Journal article, 2018)
      General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank ...

    • Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration 

      Liu, Xueping; Helenius, Dorte; Skotte, Line; Beaumont, Robin N.; Wielscher, Matthias; Geller, Frank; Juodakis, Julius; Mahajan, Anubha; Bradfield, Jonathan P.; Lin, Frederick T.J.; Vogelezang, Suzanne; Bustamante, Mariona; Ahluwalia, Tarunveer S.; Pitkänen, Niina; Wang, Carol A.; Bacelis, Jonas; Borges, Maria C.; Zhang, Ge; Bedell, Bruce A.; Rossi, Robert M.; Skogstrand, Kristin; Peng, Shouneng; Thompson, Wesley Kurt; Appadurai, Vivek; Lawlor, Debbie A.; Kalliala, Ilkka; Power, Christine; McCarthy, Mark I.; Boyd, Heather A.; Marazita, Mary L.; Hakonarson, Hakon; Hayes, M. Geoffrey; Scholtens, Denise M.; Rivadeneira, Fernando; Jaddoe, Vincent W.V.; Vinding, Rebecca K.; Bisgaard, Hans; Knight, Bridget A.; Pahkala, Katja; Raitakari, Olli; Helgeland, Øyvind; Johansson, Stefan; Njølstad, Pål Rasmus; Fadista, João; Schork, Andrew J.; Nudel, Ron; Miller, Daniel E.; Chen, Xiaoting; Weirauch, Matthew T.; Mortensen, Preben Bo; Børglum, Anders D.; Nordentoft, Merete; Mors, Ole; Hao, Ke; Ryckman, Kelli K.; Hougaard, David M.; Kottyan, Leah C.; Pennell, Craig E.; Lyytikäinen, Leo-Pekka; Bønnelykke, Klaus; Vrijheid, Martine; Felix, Janine F.; Lowe, William L.; Grant, Struan F.A.; Hyppönen, Elina; Jacobsson, Bo; Jarvelin, Marjo-Riitta; Muglia, Louis J.; Murray, Jeffrey C.; Freathy, Rachel M.; Werge, Thomas M.; Melbye, Mads; Buil, Alfonso; Feenstra, Bjarke (Peer reviewed; Journal article, 2019-09-02)
      The duration of pregnancy is influenced by fetal and maternal genetic and non-genetic factors. Here we report a fetal genome-wide association meta-analysis of gestational duration, and early preterm, preterm, and postterm ...

    • The WID-BC-index identifies women with primary poor prognostic breast cancer based on DNA methylation in cervical samples 

      Barrett, James E.; Herzog, Chiara; Jones, Allison; Leavy, Olivia C.; Evans, Iona; Knapp, Susanne; Reisel, Daniel; Nazarenko, Tatiana; Kim, Yoo-Na; Franchi, Dorella; Ryan, Andy; Franks, Joanna; Bjørge, Line; Zikan, Michal; Cibula, David; Harbeck, Nadia; Colombo, Nicoletta; Dudbridge, Frank; Jones, Louise; Sundström, Karin; Dillner, Joakim; Rådestad, Angelique Flöter; Gemzell-Danielsson, Kristina; Pashayan, Nora; Widschwendter, Martin (Journal article; Peer reviewed, 2022)
      Genetic and non-genetic factors contribute to breast cancer development. An epigenome-based signature capturing these components in easily accessible samples could identify women at risk. Here, we analyse the DNA methylome ...