Department of Clinical Medicine: Nye registreringer
Viser treff 61-80 av 2047
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Did a New Design of the Oxford Unicompartmental Knee Prosthesis Result in Improved Survival? A Study From the Norwegian Arthroplasty Register 2012-2021
(Journal article; Peer reviewed, 2023)Background Unicompartmental knee arthroplasty (UKA) has generally shown higher revision rates than TKA, and this is particularly true for the femoral component. A twin-peg femoral component (Oxford Partial) has replaced ... -
A comparison of men and women undergoing septoplasty—the Swedish national septoplasty register
(Journal article; Peer reviewed, 2023)Objective: Men represent more than two-thirds of septoplasty patients in many studies, but differences between men and women in terms of patient selection or outcome are seldom reported. This study aims to investigate ... -
Deoxyribonucleoside treatment rescues EtBr-induced mtDNA depletion in iPSC-derived neural stem cells with POLG mutations
(Journal article; Peer reviewed, 2023)Mutations in POLG, the gene encoding the catalytic subunit of the mitochondrial DNA (mtDNA) polymerase gamma (Pol-γ), lead to diseases driven by defective mtDNA maintenance. Despite being the most prevalent cause of ... -
Endeavouring interplay: a grounded theory study of how nurse educators’ work with simulation-based learning
(Journal article; Peer reviewed, 2023)Background Simulation-based learning is frequently used as a teaching and learning strategy in nursing and other health professions educations, and educators have a key role as facilitators. This facilitator role provides ... -
Improving the quality of the fracture liaison service through the implementation of a structured health record
(Journal article; Peer reviewed, 2023)Objective According to the best practice framework for secondary fracture prevention, all patients aged ≥50 years with a fracture should be assessed for osteoporosis within the fracture liaison service (FLS). The framework ... -
PPAR-gamma agonist pioglitazone recovers mitochondrial quality control in fibroblasts from PITRM1-deficient patients
(Journal article; Peer reviewed, 2023)Introduction: Biallelic variants in PITRM1 are associated with a slowly progressive syndrome characterized by intellectual disability, spinocerebellar ataxia, cognitive decline and psychosis. The pitrilysin metallopeptidase ... -
Splenic injury from blunt trauma
(Journal article; Peer reviewed, 2023) -
An idiosyncratic zonated stroma encapsulates desmoplastic liver metastases and originates from injured liver
(Journal article; Peer reviewed, 2023)A perimetastatic capsule is a strong positive prognostic factor in liver metastases, but its origin remains unclear. Here, we systematically quantify the capsule’s extent and cellular composition in 263 patients with ... -
Vessel size as a marker of survival in estrogen receptor positive breast cancer
(Journal article; Peer reviewed, 2023)Purpose: Angiogenesis is crucial for tumor growth and is one of the hallmarks of cancer. In this study, we analyzed microvessel density, vessel median size, and perivascular a-SMA expression as prognostic biomarkers in ... -
The CLARION study: first report on safety findings in patients newly initiating treatment with cladribine tablets or fingolimod for multiple sclerosis
(Journal article; Peer reviewed, 2023)Objectives As part of the CLARION study: (1) characterize the incidence of severe infections, herpes zoster, and malignancies in patients newly initiating cladribine or fingolimod for relapsing multiple sclerosis (MS); ... -
Diagnosis and therapy of myasthenia gravis—the patients’ perspective: a cross-sectional study
(Journal article; Peer reviewed, 2023)The survey aimed to explore patients’ perspectives with myasthenia gravis (MG) toward the diagnosis made and the therapy used to treat MG. The survey was conducted with a quantitative method, using the CAWI technique. A ... -
Effects of diets containing fish oils or fish oil concentrates with high cetoleic acid content on the circulating cholesterol concentration in rodents. A systematic review and meta-analysis
(Journal article; Peer reviewed, 2023)Hypercholesterolaemia is a major risk factor for CVD. Fish intake is associated with lower risk of CVD, whereas supplementation with n-3 long-chain PUFA (LC-PUFA) has little effect on the cholesterol concentration. We ... -
Validity of the total SOFA score in patients ≥ 80 years old acutely admitted to intensive care units: a post-hoc analysis of the VIP2 prospective, international cohort study
(Journal article; Peer reviewed, 2023)Background Little is known about the performance of the Sequential Organ Failure Assessment (SOFA) score in older critically ill adults. We aimed to evaluate the prognostic impact of physiological disturbances in the ... -
Glomerular proteomic profiling reveals early differences between preexisting and de novo type 2 diabetes in human renal allografts
(Journal article; Peer reviewed, 2023)Background Diabetes mellitus (DM), either preexisting or developing after transplantation, remains a crucial clinical problem in kidney transplantation. To obtain insights into the molecular mechanisms underlying PTDM ... -
Pregnancy, folic acid, and antiseizure medication
(Journal article; Peer reviewed, 2023)Background Although some antiseizure medications (ASMs) are teratogenic, most people with epilepsy need treatment in pregnancy. The risk of ASM fetotoxicity may be mitigated with folic acid. High-dose folic acid ... -
Complications after open and laparoscopic right-sided colectomy with central lymphadenectomy for colon cancer: randomized controlled trial
(Journal article; Peer reviewed, 2023)Background A central lymphadenectomy in right-sided colon cancer involves dissection along the superior mesenteric axis, but the extent is debated due to a lack of consensus and the fear of major complications. This ... -
Early screening outcomes before, during, and after a randomized controlled trial with digital breast tomosynthesis
(Journal article; Peer reviewed, 2023)Purpose To describe and compare early screening outcomes before, during and after a randomized controlled trial with digital breast tomosynthesis (DBT) including synthetic 2D mammography versus standard digital mammography ... -
Reduced heart rate variability during mania in a repeated naturalistic observational study
(Journal article; Peer reviewed, 2023)Background: Bipolar disorder (BD) is a chronic recurrent mood disorder associated with autonomic nervous system (ANS) dysfunction, indexed by heart rate variability (HRV). Changes in HRV between mood states are sparsely ... -
Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis
(Journal article; Peer reviewed, 2023)Myasthenia gravis (MG) is a disorder of the neuromuscular junction that can deteriorate into myasthenic crisis, involving weakness of bulbar and respiratory muscles. In this study, we describe the clinical manifestations ... -
Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease
(Journal article; Peer reviewed, 2023)Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ...