Blar i Research centres and projects på utgivelsesdato

Viser treff 41-60 av 470

    • Generating transgenic reporter lines for studying nervous system development in the cnidarian nematostella vectensis 

      Rentzsch, Fabian; Renfer, Eduard; Technau, Ulrich (Journal article; Peer reviewed, 2020)
      Neurons often display complex morphologies with long and fine processes that can be difficult to visualize, in particular in living animals. Transgenic reporter lines in which fluorescent proteins are expressed in defined ...

    • Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels 

      Lynagh, Timothy (Journal article; Peer reviewed, 2020)
      Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride ...

    • Functional annotation of human long noncoding RNAs via molecular phenotyping 

      Ramilowski, Jordan; Yip, Chiu Wai Mickey; Agrawal, Saumya; Chang, Jen-Chien; Ciani, Yari; Kulakovskiy, Ivan; Mendez, Mickaël; Ching Ooi, Jasmine Li; Ouyang, John F; Parkinson, Nick; Kasukawa, Takeya; Kauppinen, Sakari; Kere, Juha; Lenhard, Boris; Schneider, Claudio; Suzuki, Harukazu; Yagi, Ken; De Hoon, Michiel J L; Shin, Jay W; Piero, Carninci (Journal article; Peer reviewed, 2020)
      Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...

    • The visual pigment xenopsin is widespread in protostome eyes and impacts the view on eye evolution 

      Hausen, Harald; Döring, Clemens; Kumar, Suman; Tumu, Sharat Chandra; Kourtesis, Ioannis (Journal article; Peer reviewed, 2020)
      Photoreceptor cells in the eyes of Bilateria are often classified into microvillar cells with rhabdomeric opsin and ciliary cells with ciliary opsin, each type having specialized molecular components and physiology. First ...

    • Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom 

      Sachkova, Maria; Landau, Morani; Surm, Joachim M.; Macrander, Jason; Singer, Shir A.; Reitzel, Adam M.; Moran, Yehu (Journal article; Peer reviewed, 2020)
      The sea anemone Nematostella vectensis (Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times ...

    • Arctic Sea level Budget Assessment During the GRACE/Argo Time Period 

      Raj, Roshin Pappukutty; Andersen, Ole Baltazar; Johannessen, Johnny Andre; Benjamin, Gutknech; Chatterjee, Sourav; Rose, Stine; Bonaduce, Antonio; Horwath, Martin; Ranndal, Heidi; Richter, Kristin; Palanisamy, Hindumathi; Ludwigsen, Carsten; Bertino, Laurent; Nilsen, Jan Even Øie; Knudsen, Per; Hogg, Anna E.; Cazenave, Anny; Benveniste, Jérôme (Journal article; Peer reviewed, 2020)
      Sea level change is an important indicator of climate change. Our study focuses on the sea level budget assessment of the Arctic Ocean using: (1) the newly reprocessed satellite altimeter data with major changes in the ...

    • Methods and models in ancient history 

      Mæhle, Ingvar B.; Ravnå, Per Bjarne; Seland, Eivind Heldaas (Papers and monographs from the Norwegian Institute at Athens;9, Book, 2020)

    • The genetic basis for PRC1 complex diversity emerged early in animal evolution 

      Gahan, James; Rentzsch, Fabian; Schnitzler, Christine E. (Journal article; Peer reviewed, 2020)
      Polycomb group proteins are essential regulators of developmental processes across animals. Despite their importance, studies on Polycomb are often restricted to classical model systems and, as such, little is known about ...

    • Heterogenic Origin of Micro RNAs in Atlantic Salmon (Salmo salar) Seminal Plasma 

      Bizuayehu, Teshome Tilahun; Babiak, Igor (Journal article; Peer reviewed, 2020)
      The origin and contribution of seminal plasma RNAs into the whole semen RNA repertoire are poorly known, frequently being overlooked or neglected. In this study, we used high-throughput sequencing and RT-qPCR to profile ...

    • Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 

      Lewis, Samuel H.; Ross, Laura; Bain, Stevie A.; Pahita, Eleni; Smith, Stephen A.; Cordaux, Richard; Miska, Eric A.; Lenhard, Boris; Jiggins, Francis M.; Sarkies, Peter (Journal article; Peer reviewed, 2020)
      Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters ...

    • RADICL-seq identifies general and cell type–specific principles of genome-wide RNA-chromatin interactions 

      Bonetti, Alessandro; Agostini, Federico; Suzuki, Ana Maria; Hashimoto, Kosuke; Pascarella, Giovanni; Gimenez, Juliette; Roos, Leonie; Nash, Alex J.; Ghilotti, Marco; Cameron, Christopher J.  F.; Valentine, Matthew; Medvedeva, Yulia A.; Noguchi, Shuhei; Agirre, Eneritz; Kashi, Kaori; Samudyata, Samudyata; Luginbühl, Joachim; Cazzoli, Riccardo; Agrawal, Saumya; Luscombe, Nicholas M.; Blanchette, Mathieu; Kasukawa, Takeya; de Hoon, Michiel; Arner, Erik; Lenhard, Boris; Plessy, Charles; Castelo-Branco, Gonçalo; Orlando, Valerio; Carninci, Piero (Journal article; Peer reviewed, 2020)
      Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. ...

    • Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers 

      Cerullo, Antonio R.; Lai, Tsoi Ying; Allam, Bassem; Baer, Alexander; Barnes, W. Jon P.; Barrientos, Zaidett; Deheyn, Dimitri D.; Fudge, Douglas S.; Gould, John A.; Harrington, Matthew J.; Holford, Mandë; Hung, Chia-Suei; Jain, Gaurav; Mayer, Georg; Medina, Mónica; Monge-Nájera, Julian; Napolitano, Tanya; Pales Espinosa, Emmanuelle; Schmidt, Stephan; Thompson, Eric; Braunschweig, Adam B. (Journal article; Peer reviewed, 2020)
      The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the ...

    • Oikopleura 

      Glover, Joel (Journal article; Peer reviewed, 2020)

    • Gene expression profiles of dicyemid life-cycle stages may explain how dispersing larvae locate new hosts 

      Lu, Tsai-Ming; Furuya, Hidetaka; Satoh, Noriyuki (Journal article; Peer reviewed, 2019-11-13)
      Metazoans have evolved a great variety of life histories in response to environmental conditions. A unique example is encountered in dicyemid mesozoans. In addition to a highly simplified adult body comprising only ~ 30 ...

    • CNEr: A toolkit for exploring extreme noncoding conservation 

      Tan, Ge; Polychronopoulos, Dimitris; Lenhard, Boris (Journal article; Peer reviewed, 2019-08-26)
      Conserved Noncoding Elements (CNEs) are elements exhibiting extreme noncoding conservation in Metazoan genomes. They cluster around developmental genes and act as long-range enhancers, yet nothing that we know about their ...

    • A non-bilaterian perspective on the development and evolution of animal digestive systems 

      Steinmetz, Patrick (Journal article; Peer reviewed, 2019-08-07)
      Digestive systems and extracellular digestion are key animal features, but their emergence during early animal evolution is currently poorly understood. As the last common ancestor of non-bilaterian animal groups (sponges, ...

    • A nemertean excitatory peptide/CCHamide regulates ciliary swimming in the larvae of Lineus longissimus 

      Thiel, Daniel; Bauknecht, Philipp; Jékely, Gáspár; Hejnol, Andreas (Journal article; Peer reviewed, 2019-07-10)
      Background The trochozoan excitatory peptide (EP) and its ortholog, the arthropod CCHamide, are neuropeptides that are only investigated in very few animal species. Previous studies on different trochozoan species focused ...

    • Embryonic expression of priapulid Wnt genes 

      Hogvall, Mattias; Vellutini, Bruno Cossermelli; Martin-Duran, José M.; Hejnol, Andreas; Budd, Graham E.; Janssen, Ralf (Journal article; Peer reviewed, 2019-07)
      Posterior elongation of the developing embryo is a common feature of animal development. One group of genes that is involved in posterior elongation is represented by the Wnt genes, secreted glycoprotein ligands that signal ...

    • Transcription start site mapping using super-low input carrier-CAGE 

      Cvetesic, Nevena; Pahita, Elena; Lenhard, Boris (Journal article; Peer reviewed, 2019-06-26)
      Cap analysis of gene expression (CAGE) is a method used for single-nucleotide resolution detection of RNA polymerase II transcription start sites (TSSs). Accurate detection of TSSs enhances identification and discovery of ...

    • The Birth and Death of Toxins with Distinct Functions: A Case Study in the Sea Anemone Nematostella 

      Sachkova, Maria; Singer, Shir A; Macrander, Jason; Reitzel, Adam M.; Peigneur, Steve; Tytgat, Jan; Moran, Yehu (Journal article; Peer reviewed, 2019-05-27)
      The cnidarian Nematostella vectensis has become an established lab model, providing unique opportunities for venom evolution research. The Nematostella venom system is multimodal: involving both nematocytes and ectodermal ...