Research centres and projects: Nye registreringer

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    • Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis 

      Gahan, James Michael; Kouzel, Ivan; Ormevik Jansen, Kamilla; Burkhardt, Pawel; Rentzsch, Fabian (Journal article; Peer reviewed, 2022)
      Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a diverse set of proteins, which themselves are tightly regulated in a ...

    • The portrait face : understanding realism and verism in Greek and Roman portraiture 

      Dillon, Sheila; Prusac-Lindhagen, Marina; Lundgren, Astri Karine (Papers and monographs from the Norwegian Institute at Athens;Volume 11, Book, 2021)

    • Supracellular organization confers directionality and mechanical potency to migrating pairs of cardiopharyngeal progenitor cells 

      Bernadskaya, Yelena Y.; Yue, Haicen; Copos, Calina; Christiaen, Lionel; Mogilner, Alex (Journal article; Peer reviewed, 2021)
      Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale ...

    • Hellenistic Portraits between the Ideal and the Real 

      Kiilerich, Bente (Journal article; Peer reviewed, 2021)
      Hellenistic portraiture comprises many visual expressions ranging from the ideal to the real. Several factors play a part in the shaping of this diverse portrait art. From the 4th century BC onwards, there was a growing ...

    • Neuronal genes deregulated in Cornelia de Lange Syndrome respond to removal and re-expression of cohesin 

      Weiss, Felix D.; Calderon, Lesly; Wang, Yi-Fang; Georgieva, Radina; Guo, Ya; Cvetesic, Nevena; Kaur, Maninder; Dharmalingam, Gopuraja; Krantz, Ian D.; Lenhard, Boris; Fisher, Amanda G.; Merkenschlager, Matthias (Journal article; Peer reviewed, 2021)
      Cornelia de Lange Syndrome (CdLS) is a human developmental disorder caused by mutations that compromise the function of cohesin, a major regulator of 3D genome organization. Cognitive impairment is a universal and as yet ...

    • Mesmerize is a dynamically adaptable user-friendly analysis platform for 2D and 3D calcium imaging data 

      Kolar, Kushal; Dondorp, Daniel; Zwiggelaar, Jordi Cornelis; Høyer, Jørgen; Chatzigeorgiou, Marios (Journal article; Peer reviewed, 2021)
      Calcium imaging is an increasingly valuable technique for understanding neural circuits, neuroethology, and cellular mechanisms. The analysis of calcium imaging data presents challenges in image processing, data organization, ...

    • The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes 

      Vöcking, Oliver; Leclère, Lucas; Hausen, Harald (Journal article; Peer reviewed, 2021-11-29)
      Background: The process of photoreception in most animals depends on the light induced isomerization of the chromophore retinal, bound to rhodopsin. To re-use retinal, the all-trans-retinal form needs to be re-isomerized ...

    • Choanoflagellates and the ancestry of neurosecretory vesicles 

      Göhde, Ronja Alica Angelika; Naumann, Benjamin; Laundon, Davis; Imig, Cordelia; McDonald, Kent; Cooper, Benjamin H.; Varoqueaux, Frédérique; Fasshauer, Dirk; Burkhardt, Pawel (Journal article; Peer reviewed, 2021)
      Neurosecretory vesicles are highly specialized trafficking organelles that store neurotransmitters that are released at presynaptic nerve endings and are, therefore, important for animal cell–cell signalling. Despite ...

    • Constituting Artemis : the social and cultural significance of votive offerings in the cults of Artemis at Brauron, Ephesos and Sparta 

      Johannessen, Lene Os (Papers and monographs from the Norwegian Institute at Athens;Volume 10, Book, 2021)

    • Molecular evidence for a single origin of ultrafiltration-based excretory organs 

      Gasiorowski, Ludwik; Andrikou, Carmen; Bump, Paul; Lowe, Christopher J.; Janssen, Ralf; Budd, Graham E.; Hejnol, Andreas (Journal article; Peer reviewed, 2021)
      Excretion is an essential physiological process, carried out by all living organisms, regardless of their size or complexity.1, 2, 3 Both protostomes (e.g., flies and flatworms) and deuterostomes (e.g., humans and sea ...

    • Extreme Levels of Ocean Acidification Restructure the Plankton Community and Biogeochemistry of a Temperate Coastal Ecosystem: A Mesocosm Study 

      Spisla, Carsten; Taucher, Jan; Bach, Lennart T; Haunost, Mathias; Boxhammer, Tim; King, Andrew L; Jenkins, Bettany D.; Wallace, Joselynn R.; Ludwig, Andrea; Meyer, Jana; Stange, Paul; Minutolo, Fabrizio; Lohbeck, Kai T.; Nauendorf, Alice; Kalter, Verena; Lischka, Silke; Sswat, Michael; Dörner, Isabel; Ismar-Rebitz, Stefanie M. H.; Aberle, Nicole; Yong, Jaw C; Bouquet, Jean-Marie; Lechtenbörger, Anna K.; Kohnert, Peter; Krudewig, Michael; Riebesell, Ulf (Journal article; Peer reviewed, 2021)
      The oceans’ uptake of anthropogenic carbon dioxide (CO2) decreases seawater pH and alters the inorganic carbon speciation – summarized in the term ocean acidification (OA). Already today, coastal regions experience episodic ...

    • Comparative Animal Mucomics: Inspiration for Functional Materials from Ubiquitous and Understudied Biopolymers 

      Cerullo, Antonio R.; Lai, Tsoi Ying; Allam, Bassem; Baer, Alexander; Barnes, W. Jon P.; Barrientos, Zaidett; Deheyn, Dimitri D.; Fudge, Douglas S.; Gould, John A.; Harrington, Matthew J.; Holford, Mandë; Hung, Chia-Suei; Jain, Gaurav; Mayer, Georg; Medina, Mónica; Monge-Nájera, Julian; Napolitano, Tanya; Pales Espinosa, Emmanuelle; Schmidt, Stephan; Thompson, Eric; Braunschweig, Adam B. (Journal article; Peer reviewed, 2020)
      The functions of secreted animal mucuses are remarkably diverse and include lubricants, wet adhesives, protective barriers, and mineralizing agents. Although present in all animals, many open questions related to the ...

    • Oikopleura 

      Glover, Joel (Journal article; Peer reviewed, 2020)

    • Characterization of Schistosoma mansoni Glutamate-Gated Chloride Channels 

      Lynagh, Timothy (Journal article; Peer reviewed, 2020)
      Electrophysiology is the standard method for characterizing ion channel function. Two-electrode voltage clamp is a robust and relatively simple version which can be applied to the characterization of glutamate-gated chloride ...

    • Functional annotation of human long noncoding RNAs via molecular phenotyping 

      Ramilowski, Jordan; Yip, Chiu Wai Mickey; Agrawal, Saumya; Chang, Jen-Chien; Ciani, Yari; Kulakovskiy, Ivan; Mendez, Mickaël; Ching Ooi, Jasmine Li; Ouyang, John F; Parkinson, Nick; Kasukawa, Takeya; Kauppinen, Sakari; Kere, Juha; Lenhard, Boris; Schneider, Claudio; Suzuki, Harukazu; Yagi, Ken; De Hoon, Michiel J L; Shin, Jay W; Piero, Carninci (Journal article; Peer reviewed, 2020)
      Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...

    • Conservative route to genome compaction in a miniature annelid 

      Martin-Duran, José M.; Vellutini, Bruno Cossermelli; Marletaz, Ferdinand; Cetrangolo, Viviana; Cvetesic, Nevena; Thiel, Daniel; Henriet, Simon; Grau-Bové, Xavier; Carrillo-Baltodano, Allan M.; Gu, Wenjia; Kerbl, Alexandra; Marquez, Yamile; Bekkouche, Nicolas; Chourrout, Daniel; Gómez-Skarmeta, José Luis; Irimia, Manuel; Lenhard, Boris; Worsaae, Katrine; Hejnol, Andreas (Journal article; Peer reviewed, 2021)
      The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ...

    • Toxin-like neuropeptides in the sea anemone Nematostella unravel recruitment from the nervous system to venom 

      Sachkova, Maria; Landau, Morani; Surm, Joachim M.; Macrander, Jason; Singer, Shir A.; Reitzel, Adam M.; Moran, Yehu (Journal article; Peer reviewed, 2020)
      The sea anemone Nematostella vectensis (Anthozoa, Cnidaria) is a powerful model for characterizing the evolution of genes functioning in venom and nervous systems. Although venom has evolved independently numerous times ...

    • Widespread conservation and lineage-specific diversification of genome-wide DNA methylation patterns across arthropods 

      Lewis, Samuel H.; Ross, Laura; Bain, Stevie A.; Pahita, Eleni; Smith, Stephen A.; Cordaux, Richard; Miska, Eric A.; Lenhard, Boris; Jiggins, Francis M.; Sarkies, Peter (Journal article; Peer reviewed, 2020)
      Cytosine methylation is an ancient epigenetic modification yet its function and extent within genomes is highly variable across eukaryotes. In mammals, methylation controls transposable elements and regulates the promoters ...

    • Peptide Inhibitors of the α‑Cobratoxin−Nicotinic Acetylcholine Receptor Interaction 

      Lynagh, Timothy; Kiontke, Stephan; Meyhoff-Madsen, Maria; Gless, Bengt H.; Johannesen, Jónas; Kattelmann, Sabrina; Christiansen, Anders; Dufva, Martin; Laustsen, Andreas H.; Devkota, Kanchan; Olsen, Christian A.; Kümmel, Daniel; Pless, Stephan Alexander; Lohse, Brian (Journal article; Peer reviewed, 2020)
      Venomous snakebites cause >100 000 deaths every year, in many cases via potent depression of human neuromuscular signaling by snake α-neurotoxins. Emergency therapy still relies on antibody-based antivenom, hampered by ...

    • RAB5A and TRAPPC6B are novel targets for Shiga toxin 2a inactivation in kidney epithelial cells 

      Kouzel, Ivan; Kehl, Alexander; Berger, Petya; Liashkovich, Ivan; Steil, Daniel; Makalowski, Wojciech; Suzuki, Yutaka; Pohlentz, Gottfried; Karch, Helge; Mellmann, Alexander C.; Müthing, Johannes (Journal article; Peer reviewed, 2020-03-18)
      The cardinal virulence factor of human-pathogenic enterohaemorrhagic Escherichia coli (EHEC) is Shiga toxin (Stx), which causes severe extraintestinal complications including kidney failure by damaging renal endothelial ...