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dc.contributor.authorHelgeland, Øyvindeng
dc.contributor.authorHertel, Jens Kristoffereng
dc.contributor.authorMolven, Anderseng
dc.contributor.authorRæder, Helgeeng
dc.contributor.authorPlatou, Carl Geoffrey Parrindereng
dc.contributor.authorMidthjell, Kristianeng
dc.contributor.authorHveem, Kristianeng
dc.contributor.authorNygård, Ottareng
dc.contributor.authorNjølstad, Pål R.eng
dc.contributor.authorJohansson, Stefaneng
dc.description.abstractBackground. Two adjacent regions upstream CDKN2B on chromosome 9p21 have been associated with type 2 diabetes (T2D) and progression of cardiovascular disease (CVD).The precise location and number of risk variants have not been completely delineated and a possible synergistic relationship between the adjacent regions is not fully addressed. By a population based cross-sectional case-control design, we genotyped 18 SNPs upstream of CDKN2B tagging 138 kb in and around two LD-blocks associated with CVD and T2D and investigated associations with T2D, angina pectoris (AP), myocardial infarction (MI), coronary heart disease (CHD; AP or AMI), and stroke using 5,564 subjects from HUNT2. Results. Single point and haplotype analysis showed evidence for only one common T2D risk haplotype (rs10757282|rs10811661: OR = 1.19, 𝑃� = 2.0 × 10−3) in the region.We confirmed the strong association between SNPs in the 60 kb CVD region with AP, MI, and CHD(𝑃� < 0.01). Conditioning on the lead SNPs in the region, we observed two suggestive independent single SNP association signals for MI, rs2065501 (𝑃� = 0.03) and rs3217986 (𝑃� = 0.04). Conclusions. We confirmed the association of known variants within the 9p21 interval with T2D and CHD. Our results further suggest that additional CHD susceptibility variants exist in this region.eng
dc.rightsAttribution CC BYeng
dc.titleThe Chromosome 9p21 CVD- and T2D-Associated Regions in a Norwegian Population (The HUNT2 Survey)eng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Endokrinologi: 774en_US
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Endocrinology: 774en_US
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en_US
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical genetics: 714en_US
dc.rights.holderCopyright 2015 Øyvind Helgeland et al.eng
bora.peerreviewedPeer reviewedeng
bora.journalTitleInternational Journal of Endocrinologyeng
dc.type.documentJournal articleen_US

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