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dc.contributor.authorNankabirwa, Victoriaen_US
dc.contributor.authorTumwine, James K.en_US
dc.contributor.authorMugaba, Proscovia M.en_US
dc.contributor.authorTylleskär, Thorkilden_US
dc.contributor.authorSommerfelt, Halvoren_US
dc.date.accessioned2015-12-28T11:45:45Z
dc.date.available2015-12-28T11:45:45Z
dc.date.issued2015-02-22
dc.PublishedBMC Public Health 2015, 15:175eng
dc.identifier.issn1471-2458
dc.identifier.urihttps://hdl.handle.net/1956/10825
dc.description.abstractBackground Data on non-specific effects of BCG vaccination in well described, general population African cohorts is scanty. We report the effects of BCG vaccination on post-neonatal infant and post-infancy mortality in a cohort of children in Mbale, Eastern Uganda. Methods A community-based prospective cohort study was conducted between January 2006 and February 2014. A total of 819 eligible pregnant women were followed up for pregnancy outcomes and survival of their children up to 5 years of age. Data on the children’s BCG vaccination status was collected from child health cards at multiple visits between 3 weeks and 7 years of age. Data was also collected on mothers’ residence, age, parity, household income, self-reported HIV status as well as place of birth. Multivariable Cox proportional hazards regression models taking into account potential confounders were used to estimate the association between BCG vaccination and child survival. Results The neonatal mortality risk was 22 (95% CI: 13, 35), post-neonatal infant mortality 21 (12, 34) per 1,000 live births and the mortality risk among children between 1 and 5 years of age (post-infancy) was 63 (47, 82) per 1,000 live births. The median age at BCG vaccination was 4 days. Out of 819 children, 647 (79%) had received the BCG vaccine by 24 weeks of age. In the adjusted analysis, the rate of post-neonatal death among infants vaccinated with BCG tended to be nearly half of that among those who had not received the vaccine (adjusted HR: 0.47; 95% CI: 0.14, 1.53). BCG vaccination was associated with a lower rate of death among children between 1 and 5 years of age (adjusted HR: 0.26; 95% CI: 0.14, 0.48). Conclusion The risk of early childhood death in Mbale, Uganda is unacceptably high. BCG vaccination was associated with an increased likelihood of child survival.en_US
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectBCGeng
dc.subjectVaccinationeng
dc.titleChild survival and BCG vaccination: A community based prospective cohort study in Ugandaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-11-05T10:22:06Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright Nankabirwa et al.; licensee BioMed Central. 2015
dc.identifier.doihttps://doi.org/10.1186/s12889-015-1497-8
dc.identifier.cristin1248247
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Epidemiologi medisinsk og odontologisk statistikk: 803
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Epidemiology, medical and dental statistics: 803
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Community medicine, social medicine: 801
dc.subject.nsiVDP::Medisinske Fag: 700en_US


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