dc.contributor.author | Finn, Roderick Nigel | |
dc.contributor.author | Chauvigné, Francois | |
dc.contributor.author | Stavang, Jon Anders | |
dc.contributor.author | Belles, Xavier | |
dc.contributor.author | Cerdà, Joan | |
dc.date.accessioned | 2016-01-11T11:58:24Z | |
dc.date.available | 2016-01-11T11:58:24Z | |
dc.date.issued | 2015-07-17 | |
dc.Published | Nature Communications 2015, 6:7814 | eng |
dc.identifier.issn | 2041-1723 | en_US |
dc.identifier.uri | http://hdl.handle.net/1956/10920 | |
dc.description.abstract | Transmembrane glycerol transport is typically facilitated by aquaglyceroporins in Prokaryota and Eukaryota. In holometabolan insects however, aquaglyceroporins are absent, yet several species possess polyol permeable aquaporins. It thus remains unknown how glycerol transport evolved in the Holometabola. By combining phylogenetic and functional studies, here we show that a more efficient form of glycerol transporter related to the water-selective channel AQP4 specifically evolved and multiplied in the insect lineage, resulting in the replacement of the ancestral branch of aquaglyceroporins in holometabolan insects. To recapitulate this evolutionary process, we generate specific mutants in distantly related insect aquaporins and human AQP4 and show that a single mutation in the selectivity filter converted a water-selective channel into a glycerol transporter at the root of the crown clade of hexapod insects. Integration of phanerozoic climate models suggests that these events were associated with the emergence of complete metamorphosis and the unparalleled radiation of insects. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Publishing Group (NPG) | en_US |
dc.rights | Attribution CC BY 4.0 | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | Biological sciences | eng |
dc.subject | Evolution | eng |
dc.subject | Genetics | eng |
dc.title | Insect glycerol transporters evolved by functional co-option and gene replacement | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-22T10:34:48Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 Rights Managed by Nature Publishing Group | en_US |
dc.identifier.doi | https://doi.org/10.1038/ncomms8814 | |
dc.identifier.cristin | 1276070 | |
dc.subject.nsi | VDP::Matematikk og naturvitenskap: 400::Basale biofag: 470::Genetikk og genomikk: 474 | |
dc.subject.nsi | VDP::Mathematics and natural scienses: 400::Basic biosciences: 470::Genetics and genomics: 474 | |
dc.subject.nsi | VDP::Matematikk og Naturvitenskap: 400 | en_US |