The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations
MetadataShow full item record
Auditory verbal hallucinations (AVHs) are a subjective experience of “hearing voices” in the absence of corresponding physical stimulation in the environment. The most remarkable feature of AVHs is their perceptual quality, that is, the experience is subjectively often as vivid as hearing an actual voice, as opposed to mental imagery or auditory memories. This has lead to propositions that dysregulation of the primary auditory cortex (PAC) is a crucial component of the neural mechanism of AVHs. One possible mechanism by which the PAC could give rise to the experience of hallucinations is aberrant patterns of neuronal activity whereby the PAC is overly sensitive to activation arising from internal processing, while being less responsive to external stimulation. In this paper, we review recent research relevant to the role of the PAC in the generation of AVHs. We present new data from a functional magnetic resonance imaging (fMRI) study, examining the responsivity of the left and right PAC to parametrical modulation of the intensity of auditory verbal stimulation, and corresponding attentional top-down control in non-clinical participants with AVHs, and non-clinical participants with no AVHs. Non-clinical hallucinators showed reduced activation to speech sounds but intact attentional modulation in the right PAC. Additionally, we present data from a group of schizophrenia patients with AVHs, who do not show attentional modulation of left or right PAC. The context-appropriate modulation of the PAC may be a protective factor in non-clinical hallucinations.
CitationFrontiers in Human Neuroscience 2013, 7:144
Subjectauditory verbal hallucinationsprimary auditory cortexnon-clinicalschizophreniaauditory attention
Copyright 2015 The Authors
Showing items related by title, author, creator and subject.
Sætrevik, Bjørn (The University of Bergen, 2008-05-27)The dichotic listening experimental paradigm creates an ambiguous situation for the participant by presenting two auditory stimuli simultaneously, one in each ear. Which of the stimuli the participant reports has previously ...Doctoral thesis
A synthesis of evidence on inhibitory control and auditory hallucinations based on the Research Domain Criteria (RDoC) framework Badcock, Johanna C.; Hugdahl, Kenneth (Frontiers, 2014-03-26)The National Institute of Mental Health initiative called the Research Domain Criteria (RDoC) project aims to provide a new approach to understanding mental illness grounded in the fundamental domains of human behavior and ...Journal article
Johns, Louise C.; Kompus, Kristiina; Connell, Melissa; Humpston, Clara; Lincoln, Tania M.; Longden, Eleanor; Preti, Antonio; Alderson-Day, Ben; Badcock, Johanna C.; Cella, Matteo; Fernyhough, Charles; McCarthy-Jones, Simon; Peters, Emmanuelle; Raballo, Andrea; Scott, James; Siddi, Sara; Sommer, Iris E.; Larøi, Frank (Oxford University Press, 2014)Auditory verbal hallucinations (AVH) are complex experiences that occur in the context of various clinical disorders. AVH also occur in individuals from the general population who have no identifiable psychiatric or ...Journal article