Recent Submissions

  • Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects 

    Myklebust, Line Merethe; Van Damme, Petra; Støve, Svein Isungset; Dörfel, Max J; Abboud, Angèle; Kalvik, Thomas Vikestad; Grauffel, Cédric; Jonckheere, Veronique; Wu, Yiyang; Swensen, Jeffrey; Kaasa, Hanna; Liszczak, Glen; Marmorstein, Ronen; Reuter, Nathalie; Lyon, Gholson J; Gevaert, Kris; Arnesen, Thomas (Oxford University Press, 2014-12-03)
    The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase (NAT) gene. The affected males harbor an Ser37Pro (S37P) mutation in the gene ...
    Journal article
  • Molecular analysis of the development and function of the apical organ in the sea anemone Nematostella vectensis 

    Bause, Markus (The University of Bergen, 2015-10-09)
    The shapes and patterns displayed across the animal kingdom exhibit great diversity, but at the same time similarities in their appearance can be observed. Scientist in the past have studied animal forms based on morphology. ...
    Doctoral thesis
  • Study of Ecdysone receptor and Ultraspiracle in the salmon louse (Lepeophtheirus salmonis) 

    Kar, Sukarna (The University of Bergen, 2015-05-31)
    The salmon louse (Lepeophtheirus salmonis) is a parasite living on mucus, skin and blood of salmonids fishes. L. salmonis causes lesions and infections on fish fins and skins and such physical damages often lead to ...
    Master thesis
  • Non-conserved C-terminal regions in the histone recognition module CW, determines specificity, stability and affinity towards monomethylated histone tails 

    Ødegård, Øyvind (The University of Bergen, 2014-11-20)
    Histone modifications have an important role in epigenetic gene regulation and contribute to the cellular memory system. It has been well documented that certain patterns of histone modifications are associated with different ...
    Master thesis
  • Identification of the DNA sequence encoding Neurospora crassa NADase and characterization of the recombinant protein 

    Hardardottir, Hulda Maria (The University of Bergen, 2015-06-02)
    Neurospora Crassa (N.crassa) is a bread mold that has been used as a model organism in molecular biology since the late 1920s. N.crassa NADase is an enzyme that catalyze the conversion of NAD+ to nicotinamide and ADP-ribose. ...
    Master thesis
  • Pesticides Induce Oxidative Stress in Zebrafish Embryo 

    Thorstensen, Kjetil Løtveit (The University of Bergen, 2014-06-02)
    Aquaculture is an industry in rapid global growth. The increased demand and therefore production of aquacultural goods is bound to drain natural marine resources if fish are to continue being fed feeds based solely on ...
    Master thesis
  • Comparative development of spiralian larvae 

    Vellutini, Bruno Cossermelli (The University of Bergen, 2016-03-04)
    Bryozoans and brachiopods are sessile, mostly marine animals, that use an elegant crown of tentacles for filter-feeding. They are related to molluscs, segmented worms and other animals in a outstandingly diverse group of ...
    Doctoral thesis
  • Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis 

    Linster, Eric; Stephan, Iwona; Bienvenut, Willy V.; Maple-Grødem, Jodi; Myklebust, Line Merethe; Huber, Monika; Reichelt, Michael; Sticht, Carsten; Møller, Simon Geir; Meinnel, Thierry; Arnesen, Thomas; Giglione, Carmela; Hell, Rüdiger; Wirtz, Markus (Nature Publishing Group, 2015-07-17)
    N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA ...
    Journal article
  • Redox control of protein degradation 

    Pajares, Marta; Jiménez-Moreno, Natalia; Dias, Irundika H.K.; Debelec, Bilge; Vucetic, Milica; Fladmark, Kari Espolin; Basaga, Huveyda; Ribaric, Samo; Milisav, Irina; Cuadrado, Antonio (Elsevier, 2015-12)
    Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well ...
    Journal article
  • α-lactalbumin: oleic acid complex spontaneously delivers oleic acid to artificial and erythrocyte membranes 

    Wen, Hanzhen; Strømland, Øyvind; Halskau, Øyvind (Elsevier, 2015-08-19)
    Human α-lactalbumin made lethal to tumor cells (HAMLET) is a tumoricidal complex consisting of human α-lactalbumin and multiple oleic acids (OAs). OA has been shown to play a key role in the activity of HAMLET and its ...
    Journal article
  • N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects 

    Varland, Sylvia; Osberg, Camilla; Arnesen, Thomas (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2015-06-16)
    The vast majority of eukaryotic proteins are N-terminally modified by one or more processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include different peptidases, transferases, and ligases. ...
    Journal article
  • The human NAD metabolome: Functions, metabolism and compartmentalization 

    Nikiforov, Andrey; Kulikova, Veronika; Ziegler, Mathias (Taylor & Francis, 2015)
    The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and ...
    Journal article
  • WEBnm@: a web application for normal mode analyses of proteins 

    Hollup, Siv Midtun; Sælensminde, Gisle; Reuter, Nathalie (BioMed Central, 2005-12-30)
    Background Normal mode analysis (NMA) using elastic network models is a reliable and cost-effective computational method to characterise protein flexibility and by extension, their dynamics. Further insight into the ...
    Journal article
  • Insights into NAD homeostasis in the compartmentalized cell 

    Van Linden, Magali R (The University of Bergen, 2015-08-24)
    The compartmentalized nature of eukaryotic cells requires the distribution of enzymes, metabolites, and cofactors among the organelles. This includes nicotinamide adenine dinucleotide (NAD), an essential coenzyme, precursor, ...
    Doctoral thesis
  • Comparing the intrinsic dynamics of multiple protein structures using elastic network models 

    Fuglebakk, Edvin; Tiwari, Sandhya Premnath; Reuter, Nathalie (Elsevier, 2015-05)
    Background: Elastic network models (ENMs) are based on the simple idea that a protein can be described as a set of particles connected by springs, which can then be used to describe its intrinsic flexibility using, for ...
    Journal article
  • De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females 

    Popp, Bernt; Støve, Svein Isungset; Endele, Sabine; Myklebust, Line Merethe; Hoyer, Juliane; Sticht, Heinrich; Azzarello-Burri, Silvia; Rauch, Anita; Arnesen, Thomas; Reis, André (Nature Publishing Group, 2015)
    Recent studies revealed the power of whole-exome sequencing to identify mutations in sporadic cases with non-syndromic intellectual disability. We now identified de novo missense variants in NAA10 in two unrelated individuals, ...
    Journal article
  • Lifespan extension in a semelparous chordate Oikopleura dioica via developmental growth arrest : Roles of Target of Rapamycin (TOR) signaling and D type cyclins 

    Subramaniam, Gunasekaran (The University of Bergen, 2015-05-22)
    All living organisms experience ageing during the course of their lifespan. The science of ageing has emerged into an enthralling area of research. Our knowledge of the mechanisms of ageing and reproduction has been mainly ...
    Doctoral thesis
  • Separating NADH and NADPH fluorescence in live cells and tissues using FLIM 

    Blacker, Thomas S.; Mann, Zoe F.; Gale, Jonathan E.; Ziegler, Mathias; Bain, Angus J.; Szabadkai, Gyorgy; Duchen, Michael R. (Nature Publishing Group, 2014-05-29)
    NAD is a key determinant of cellular energy metabolism. In contrast, its phosphorylated form, NADP, plays a central role in biosynthetic pathways and antioxidant defence. The reduced forms of both pyridine nucleotides are ...
    Journal article
  • Refinement of a radioreceptor binding assay for nicotinic acid adenine dinucleotide phosphate 

    Lewis, Alexamder M.; Masgrau, Roser; Vasudevan, Sridhar R.; Yarnasaki, Michiko; O'Neill, John S.; Garnham, Clive; James, Kristin; Macdonald, Andrew; Ziegler, Mathias; Galione, Antony; Churchill, Grant C. (Elsevier, 2007-12-01)
    The measurement of changes in nicotinic acid adenine dinucleotide phosphate (NAADP) levels in cells has been, and remains, key to the investigation of the functions of NAADP as a Ca2+-releasing second messenger. Here we ...
    Journal article
  • The C-terminal domain of eukaryotic initiation factor 5 promotes start codon recognition by its dynamic interplay with eIF1 and eIF2 beta 

    Luna, Rafael E.; Arthanari, Haribabu; Hiraishi, Hiroyuki; Nanda, Jagpreed; Martin-Marcos, Pilar; Markus, Michelle A.; Akabayov, Barak; Milbradt, Alexander G.; Luna, Lunet E.; Seo, Hee-Chan; Hyberts, Sven G.; Fahmy, Amr; Reibarkh, Mikhail; Miles, David; Hagner, Patrick R.; O'Day, Elizabeth M.; Yi, Tingfang; Marintchev, Assen; Hinnebusch, Alan G.; Lorsch, John R.; Asano, Katsura; Wagner, Gerhard (Elsevier, 2012-06-28)
    Recognition of the proper start codon on mRNAs is essential for protein synthesis, which requires scanning and involves eukaryotic initiation factors (eIFs) eIF1, eIF1A, eIF2, and eIF5. The carboxyl terminal domain (CTD) ...
    Journal article

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