Now showing items 21-40 of 109

    • Comparative development of spiralian larvae 

      Vellutini, Bruno Cossermelli (The University of Bergen, 2016-03-04)
      Bryozoans and brachiopods are sessile, mostly marine animals, that use an elegant crown of tentacles for filter-feeding. They are related to molluscs, segmented worms and other animals in a outstandingly diverse group of ...
      Doctoral thesis
    • A Role for Weak Electrostatic Interactions in Peripheral Membrane Protein Binding 

      Khan, Hanif Muhammad; He, Tao; Fuglebakk, Edvin; Grauffel, Cédric; Yang, Boqian; Roberts, Mary F.; Gershenson, Anne; Reuter, Nathalie (Elsevier, 2016-03)
      Bacillus thuringiensis phosphatidylinositol-specific phospholipase C (BtPI-PLC) is a secreted virulence factor that binds specifically to phosphatidylcholine (PC) bilayers containing negatively charged phospholipids. ...
      Journal article
    • Algal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometry 

      Hjørnevik, Linda Veka; Frøyset, Ann Kristin; Grønset, Toril Anne; Rungruangsak-Torrissen, Krisna; Fladmark, Kari Espolin (MDPI, 2015-12-14)
      Azaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and ...
      Journal article
    • Redox control of protein degradation 

      Pajares, Marta; Jiménez-Moreno, Natalia; Dias, Irundika H.K.; Debelec, Bilge; Vucetic, Milica; Fladmark, Kari Espolin; Basaga, Huveyda; Ribaric, Samo; Milisav, Irina; Cuadrado, Antonio (Elsevier, 2015-12)
      Intracellular proteolysis is critical to maintain timely degradation of altered proteins including oxidized proteins. This review attempts to summarize the most relevant findings about oxidant protein modification, as well ...
      Journal article
    • NAA10 mutation causing a novel intellectual disability syndrome with Long QT due to N-terminal acetyltransferase impairment 

      Casey, Jillian P.; Støve, Svein Isungset; McGorrian, Catherine; Galvin, Joseph; Blenski, Marina; Dunne, Aimee; Ennis, Sean; Brett, Francesca; King, Mary D.; Arnesen, Thomas; Lynch, Sally Ann (Nature Publishing Group, 2015-11-02)
      We report two brothers from a non-consanguineous Irish family presenting with a novel syndrome characterised by intellectual disability, facial dysmorphism, scoliosis and long QT. Their mother has a milder phenotype including ...
      Journal article
    • Molecular analysis of the development and function of the apical organ in the sea anemone Nematostella vectensis 

      Bause, Markus (The University of Bergen, 2015-10-09)
      The shapes and patterns displayed across the animal kingdom exhibit great diversity, but at the same time similarities in their appearance can be observed. Scientist in the past have studied animal forms based on morphology. ...
      Doctoral thesis
    • Insights into NAD homeostasis in the compartmentalized cell 

      Van Linden, Magali R (The University of Bergen, 2015-08-24)
      The compartmentalized nature of eukaryotic cells requires the distribution of enzymes, metabolites, and cofactors among the organelles. This includes nicotinamide adenine dinucleotide (NAD), an essential coenzyme, precursor, ...
      Doctoral thesis
    • α-lactalbumin: oleic acid complex spontaneously delivers oleic acid to artificial and erythrocyte membranes 

      Wen, Hanzhen; Strømland, Øyvind; Halskau, Øyvind (Elsevier, 2015-08-19)
      Human α-lactalbumin made lethal to tumor cells (HAMLET) is a tumoricidal complex consisting of human α-lactalbumin and multiple oleic acids (OAs). OA has been shown to play a key role in the activity of HAMLET and its ...
      Journal article
    • The N-terminal acetyltransferase Naa10 is essential for zebrafish development 

      Ree, Rasmus Moen; Myklebust, Line Merethe; Thiel, Puja; Foyn, Håvard; Fladmark, Kari Espolin; Arnesen, Thomas (Portland Press Limited, 2015-08-06)
      N-terminal acetylation, catalysed by N-terminal acetyltransferases (NATs), is among the most common protein modifications in eukaryotes and involves the transfer of an acetyl group from acetyl-CoA to the α-amino group of ...
      Journal article
    • Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis 

      Linster, Eric; Stephan, Iwona; Bienvenut, Willy V.; Maple-Grødem, Jodi; Myklebust, Line Merethe; Huber, Monika; Reichelt, Michael; Sticht, Carsten; Møller, Simon Geir; Meinnel, Thierry; Arnesen, Thomas; Giglione, Carmela; Hell, Rüdiger; Wirtz, Markus (Nature Publishing Group, 2015-07-17)
      N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA ...
      Journal article
    • Brd4 as a candidate protein for the recognition of histone H3 lysine 27 acetylation 

      Stensland, Ingvild Gausemel (The University of Bergen, 2015-06-29)
      Post-translational modifications (PTMs) of histone tails are associated with the regulation of transcriptional processes. Patterns of histone modifications mark regions of high or low transcriptional activity, and are ...
      Master thesis
    • N-terminal modifications of cellular proteins: the enzymes involved, their substrate specificities and biological effects 

      Varland, Sylvia; Osberg, Camilla; Arnesen, Thomas (Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2015-06-16)
      The vast majority of eukaryotic proteins are N-terminally modified by one or more processing enzymes. Enzymes acting on the very first amino acid of a polypeptide include different peptidases, transferases, and ligases. ...
      Journal article
    • Study of Ecdysone receptor and Ultraspiracle in the salmon louse (Lepeophtheirus salmonis) 

      Kar, Sukarna (The University of Bergen, 2015-05-31)
      The salmon louse (Lepeophtheirus salmonis) is a parasite living on mucus, skin and blood of salmonids fishes. L. salmonis causes lesions and infections on fish fins and skins and such physical damages often lead to ...
      Master thesis
    • Lifespan extension in a semelparous chordate Oikopleura dioica via developmental growth arrest : Roles of Target of Rapamycin (TOR) signaling and D type cyclins 

      Subramaniam, Gunasekaran (The University of Bergen, 2015-05-22)
      All living organisms experience ageing during the course of their lifespan. The science of ageing has emerged into an enthralling area of research. Our knowledge of the mechanisms of ageing and reproduction has been mainly ...
      Doctoral thesis
    • Comparing the intrinsic dynamics of multiple protein structures using elastic network models 

      Fuglebakk, Edvin; Tiwari, Sandhya Premnath; Reuter, Nathalie (Elsevier, 2015-05)
      Background: Elastic network models (ENMs) are based on the simple idea that a protein can be described as a set of particles connected by springs, which can then be used to describe its intrinsic flexibility using, for ...
      Journal article
    • Homeodomain transcription factors Six3 and Six6 have distinct protein binding characteristics 

      Turcu, Diana Cornelia (The University of Bergen, 2015-02-20)
      The goal of this study was to characterize Six3 and Six6 proteins interactions and to better understand their functions. The Six class proteins are found in a wide variety of animals ranging from primitive invertebrate ...
      Doctoral thesis
    • De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females 

      Popp, Bernt; Støve, Svein Isungset; Endele, Sabine; Myklebust, Line Merethe; Hoyer, Juliane; Sticht, Heinrich; Azzarello-Burri, Silvia; Rauch, Anita; Arnesen, Thomas; Reis, André (Nature Publishing Group, 2015)
      Recent studies revealed the power of whole-exome sequencing to identify mutations in sporadic cases with non-syndromic intellectual disability. We now identified de novo missense variants in NAA10 in two unrelated individuals, ...
      Journal article
    • The human NAD metabolome: Functions, metabolism and compartmentalization 

      Nikiforov, Andrey; Kulikova, Veronika; Ziegler, Mathias (Taylor & Francis, 2015)
      The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and ...
      Journal article
    • Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects 

      Myklebust, Line Merethe; Van Damme, Petra; Støve, Svein Isungset; Dörfel, Max J; Abboud, Angèle; Kalvik, Thomas Vikestad; Grauffel, Cédric; Jonckheere, Veronique; Wu, Yiyang; Swensen, Jeffrey; Kaasa, Hanna; Liszczak, Glen; Marmorstein, Ronen; Reuter, Nathalie; Lyon, Gholson J; Gevaert, Kris; Arnesen, Thomas (Oxford University Press, 2014-12-03)
      The X-linked lethal Ogden syndrome was the first reported human genetic disorder associated with a mutation in an N-terminal acetyltransferase (NAT) gene. The affected males harbor an Ser37Pro (S37P) mutation in the gene ...
      Journal article
    • Two homologous neutrophil serine proteases bind to POPC vesicles with different affinities: When aromatic amino acids matter 

      Schillinger, Anne-Sophie; Grauffel, Cédric; Khan, Hanif Muhammad; Halskau, Øyvind; Reuter, Nathalie (Elsevier, 2014-12)
      Neutrophil serine proteases Proteinase 3 (PR3) and human neutrophil elastase (HNE) are homologous antibiotic serine proteases of the polymorphonuclear neutrophils. Despite sharing a 56% sequence identity they have been ...
      Journal article