Timing of use of cod liver oil, a vitamin D source, and multiple sclerosis risk: The EnvIMS study.

Abstract

<p>Background: Low vitamin D levels have been associated with an increased risk of multiple sclerosis (MS), although it remains unknown whether this relationship varies by age.</p> <p>Objective: The objective of this paper is to investigate the association between vitamin D3 supplementation through cod liver oil at different postnatal ages and MS risk.</p> <p>Methods: In the Norwegian component of the multinational case-control study Environmental Factors In Multiple Sclerosis (EnvIMS), a total of 953 MS patients with maximum disease duration of 10 years and 1717 controls reported their cod liver oil use from childhood to adulthood.</p> <p>Results: Self-reported supplement use at ages 13&ndash;18 was associated with a reduced risk of MS (OR 0.67, 95% CI 0.52&ndash;0.86), whereas supplementation during childhood was not found to alter MS risk (OR 1.01, 95% CI 0.81&ndash;1.26), each compared to non-use during the respective period. An inverse association was found between MS risk and the dose of cod liver oil during adolescence, suggesting a dose-response relationship (p trend = 0.001) with the strongest effect for an estimated vitamin D3 intake of 600&ndash;800 IU/d (OR 0.46, 95% CI 0.31&ndash;0.70).</p> <p>Conclusions: These findings not only support the hypothesis relating to low vitamin D as a risk factor for MS, but further point to adolescence as an important susceptibility period for adult-onset MS.</p>