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dc.contributor.authorSchrama, Johannes Cornelisen_US
dc.contributor.authorFenstad, Anne Marieen_US
dc.contributor.authorDale, Håvarden_US
dc.contributor.authorHallan, Geiren_US
dc.contributor.authorOvergaard, Sørenen_US
dc.contributor.authorPedersen, Alma Ben_US
dc.contributor.authorKärrholm, Johanen_US
dc.contributor.authorGarellick, Göranen_US
dc.contributor.authorPulkkinen, Pekkaen_US
dc.contributor.authorEskelinen, Anttien_US
dc.contributor.authorMäkelä, Keijoen_US
dc.contributor.authorEngesæter, Lars B.en_US
dc.contributor.authorFevang, Bjørg-Tildeen_US
dc.date.accessioned2016-02-26T10:25:33Z
dc.date.available2016-02-26T10:25:33Z
dc.date.issued2015
dc.PublishedActa Orthopaedica 2015, 86(4):469-476eng
dc.identifier.issn1745-3682
dc.identifier.urihttps://hdl.handle.net/1956/11390
dc.description.abstractBackground and purpose — Medical treatment of rheumatoid arthritis (RA) has changed dramatically over the last 15 years, including immune modulation. We investigated the risk of revision for infection after primary total hip replacement (THR) in patients with rheumatoid arthritis over a 16-year period, and compared it with that in THR patients with osteoarthritis (OA). Patients and methods — We identified 13,384 THRs in RA patients and 377,287 THRs in OA patients from 1995 through 2010 in a dataset from the Nordic Arthroplasty Register Association (NARA). Kaplan-Meier survival curves, with revision for infection as the endpoint, were constructed. Cox regression analyses were performed to calculate the relative risk (RR) of revision for infection adjusted for age, sex, fixation technique, and year of primary surgery. Results — RA patients had a 1.3 times (95% CI 1.0–1.6) higher risk of revision for infection. After 2001, this risk increased more for RA patients than for OA patients. During the first 3 months and from 8 years postoperatively, the risk of revision for infection was higher in RA patients with THRs fixated with antibiotic-loaded cement than in corresponding OA patients. Interpretation — We found a slightly higher overall risk of revision for infection in RA patients than in OA patients, but this difference was only present after 2001. In THRs with antibiotic-loaded cement, the risk of very early and late infections leading to revision was higher in RA patients than in OA patients.en_US
dc.language.isoengeng
dc.publisherTaylor & Franciseng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/8529" target="_blank">Infected Hip and Knee Arthroplasties in Rheumatoid Arthritis. A register-based study with focus on risk factors</a>
dc.rightsAttribution CC BY-NC-NDeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/eng
dc.titleIncreased risk of revision for infection in rheumatoid arthritis patients with total hip replacements. A study of 390,671 primary arthroplasties from the Nordic Arthroplasty Register Associationen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-12-30T17:11:27Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright Nordic Orthopaedic Federation
dc.identifier.doihttps://doi.org/10.3109/17453674.2015.1017793
dc.identifier.cristin1276026


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