dc.contributor.author | Linster, Eric | |
dc.contributor.author | Stephan, Iwona | |
dc.contributor.author | Bienvenut, Willy V. | |
dc.contributor.author | Maple-Grødem, Jodi | |
dc.contributor.author | Myklebust, Line Merethe | |
dc.contributor.author | Huber, Monika | |
dc.contributor.author | Reichelt, Michael | |
dc.contributor.author | Sticht, Carsten | |
dc.contributor.author | Møller, Simon Geir | |
dc.contributor.author | Meinnel, Thierry | |
dc.contributor.author | Arnesen, Thomas | |
dc.contributor.author | Giglione, Carmela | |
dc.contributor.author | Hell, Rüdiger | |
dc.contributor.author | Wirtz, Markus | |
dc.date.accessioned | 2016-03-03T12:03:30Z | |
dc.date.available | 2016-03-03T12:03:30Z | |
dc.date.issued | 2015-07-17 | |
dc.Published | Nature Communications 2015, 6:7640 | eng |
dc.identifier.issn | 2041-1723 | en_US |
dc.identifier.uri | https://hdl.handle.net/1956/11428 | |
dc.description.abstract | N-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA complex and reveal evolutionary conservation of NatA biochemical properties in higher eukaryotes and uncover specific and essential functions of NatA for development, biosynthetic pathways and stress responses in plants. We show that NTA decreases significantly after drought stress, and NatA abundance is rapidly downregulated by the phytohormone abscisic acid. Accordingly, transgenic downregulation of NatA induces the drought stress response and results in strikingly drought resistant plants. Thus, we propose that NTA by the NatA complex acts as a cellular surveillance mechanism during stress and that imprinting of the proteome by NatA is an important switch for the control of metabolism, development and cellular stress responses downstream of abscisic acid. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-12-30T17:09:17Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 The Authors | en_US |
dc.identifier.doi | https://doi.org/10.1038/ncomms8640 | |
dc.identifier.cristin | 1275548 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk biokjemi: 726 | |
dc.subject.nsi | VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical biochemistry: 726 | |