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dc.contributor.authorVeen, Torhild
dc.contributor.authorStormark, Kjartan
dc.contributor.authorNedrebø, Bjørn Steinar Olden
dc.contributor.authorBerg, Marianne
dc.contributor.authorSøreide, Jon Arne
dc.contributor.authorKørner, Hartwig
dc.contributor.authorSøreide, Kjetil
dc.date.accessioned2016-03-07T13:36:10Z
dc.date.available2016-03-07T13:36:10Z
dc.date.issued2015-09
dc.identifier.citationJournal of Gastrointestinal Cancer 2015, 46(3):259-266eng
dc.identifier.urihttp://hdl.handle.net/1956/11458
dc.description.abstract<p>Purpose: In patients with a high life expectancy at the time of surgery for colorectal cancer (CRC), the long-term outcome may be influenced by factors other than their cancer. We aimed to investigate the long-term outcome and cause of death beyond a 5-year surveillance programme.</p> <p>Methods: We evaluated the overall survival (OS) and cancer-specific survival (CSS) of a population-based cohort of stage I&ndash;III CRC patients &lt;75 years old who completed a systematic surveillance programme.</p> <p>Results: In total, 161 patients &lt;75 years old, 111 (69 %) of whom were node negative (pN0), were included. The median follow-up time was 12.1 years. The OS was 54 % at 15 years and differed significantly between the pN0 and pN+ patients (65 vs. 30 %; P&thinsp;&lt;&thinsp;0.001); CSS (72 %) also differed between the pN0 and pN+ patients (85 vs. 44 %; P&thinsp;&lt;&thinsp;0.001). For the 5-year survivors (n&thinsp;=&thinsp;119), 14 (12 %) died of CRC during additional long-term follow-up (7 each for pN0 and pN+), and 6 patients (5 %; all pN0) died of other cancers. Patients aged &lt;65 years exhibited better long-term survival (81 %), but most of the deaths were due to CRC (10/12 deaths). Only two of the 14 cancer-related deaths involved microsatellite instable (MSI) CRC. Females exhibited better OS and CSS beyond 5 years of surveillance.</p> <p>Conclusions: The long-term survival beyond 5-year survivorship for stage I&ndash;III CRC is very good. Nonetheless, cancer-related deaths are encountered in one-third of patients and occur most frequently in patients who are &lt;65 years old at disease onset&mdash;pointing to a still persistent risk several years after surgery.</p>eng
dc.language.isoengeng
dc.publisherSpringereng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectColorectal cancereng
dc.subjectSurvivaleng
dc.subjectLong-term follow-upeng
dc.subjectSurveillanceeng
dc.subjectRecurrenceeng
dc.subjectMicrosatellite instabilityeng
dc.titleLong-term follow-up and survivorship after completing systematic surveillance in stage I–III colorectal cancer: who is still at risk?eng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Gasteroenterologisk kirurgi: 781
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Gastroscopic surgery: 781
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Onkologi: 762
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Oncology: 762
dc.date.updated2015-11-10T12:08:08Z
dc.rights.holderCopyright 2015 The Authorseng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1253602
dc.identifier.doi10.1007/s12029-015-9723-2eng
dc.source.issn1941-6636eng
bora.bpoaIDbpoa422


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