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    • Accumulation dynamics of transcripts and proteins of cold-responsive genes in fragaria vesca genotypes of differing cold tolerance 

      Fattash, Isam; Deitch, Zachary; Njah, Relindis Ghai; Osuagwu, Nelson Uchechukwu; Mageney, Vera; Wilson, Robert Charles; Davik, Jahn; Alsheikh, Muath K; Randall, Stephen K. (Journal article; Peer reviewed, 2021)
      Identifying and characterizing cold responsive genes in Fragaria vesca associated with or responsible for low temperature tolerance is a vital part of strawberry cultivar development. In this study we have investigated the ...

    • Accumulation of Globotriaosylceramide in Podocytes in Fabry Nephropathy Is Associated with Progressive Podocyte Loss 

      Najafian, Behzad; Tøndel, Camilla; Svarstad, Einar; Gubler, Marie-Claire; Oliveira, Joao-Paulo; Mauer, Michael (Journal article; Peer reviewed, 2020)
      Background In males with classic Fabry disease, the processes leading to the frequent outcome of ESKD are poorly understood. Defects in the gene encoding α-galactosidase A lead to accumulation of globotriaosylceramide (GL3) ...

    • Accumulation of α-synuclein mediates podocyte injury in Fabry nephropathy 

      Braun, Fabian; Abed, Ahmed; Sellung, Dominik; Rogg, Manuel; Woidy, Mathias; Eikrem, Øystein Solberg; Wanner, Nicola; Gambardella, Jessica; Laufer, Sandra; Haas, Fabian; Wong, Milagros; Dumoulin, Bernhard; Rischke, Paula; Mühlig, Anne; Sachs, Wiebke; von Cossel, Katharina M; Schulz, Kristina; Muschol, Nicole; Gersting, Sören; Muntau, Ania C.; Kretz, Oliver; Hahn, Oliver; Rinschen, Markus; Mauer, Michael; Bork, Tillmann; Grahammer, Florian; Liang, Wei; Eierhoff, Thorsten; Römer, Winfried; Hansen, Arne; Meyer-Schwesinger, Catherine; Iaccarino, Guido; Tøndel, Camilla; Marti, Hans Peter; Najafian, Behzad; Puelles, Victor G; Schell, Christoph; Huber, Tobias B (Journal article; Peer reviewed, 2023)
      Current therapies for Fabry disease are based on reversing intracellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby ...

    • Accuracy and efficiency of germline variant calling pipelines for human genome data 

      Zhao, Sen; Agafonov, Oleg; Azab, Abdulrahman; Stokowy, Tomasz; Hovig, Eivind (Journal article; Peer reviewed, 2020)
      Advances in next-generation sequencing technology have enabled whole genome sequencing (WGS) to be widely used for identification of causal variants in a spectrum of genetic-related disorders, and provided new insight into ...

    • Accuracy of single intravenous access iohexol GFR in children is hampered by marker contamination 

      Eide, Thea Tislevoll; Hufthammer, Karl Ove; Brun, Atle; Brackman, Damien; Svarstad, Einar; Tøndel, Camilla (Journal article; Peer reviewed, 2021)
      Measurement of glomerular filtration rate (GFR) in children by iohexol injection and blood sampling from the contralateral arm is widely used. A single intravenous access for iohexol injection and subsequent blood sampling ...

    • Accurate 3-gene-signature for early diagnosis of liposarcoma progression 

      Serguienko, Anastassia; Braadland, Peder Rustøen; Meza-Zepeda, Leonardo A.; Bjerkehagen, Bodil; Myklebost, Ola (Journal article; Peer reviewed, 2020)
      Background Well- and dedifferentiated liposarcoma (WD/DDLPS) are rare mesenchymal malignant tumors that account for 20% of all sarcomas in adults. The WD form is a low-grade malignancy with a favourable prognosis which ...

    • Accurate and Automated High-Coverage Identification of Chemically Cross-Linked Peptides with MaxLynx 

      Yllmaz, Şule; Busch, Florian; Nagaraj, Nagarjuna; Cox, Heinz Jürgen (Journal article; Peer reviewed, 2022)
      Cross-linking combined with mass spectrometry (XL-MS) provides a wealth of information about the three-dimensional (3D) structure of proteins and their interactions. We introduce MaxLynx, a novel computational proteomics ...

    • Accurate population-based model for individual prediction of colon cancer recurrence 

      Österman, Erik; Ekström, Joakim; Sjöblom, Tobias; Kørner, Hartwig; Myklebust, Tor Åge; Guren, Marianne; Glimelius, Bengt (Journal article; Peer reviewed, 2021)
      Background Prediction models are useful tools in the clinical management of colon cancer patients, particularly when estimating the recurrence rate and, thus, the need for adjuvant treatment. However, the most used models ...

    • Acetaminophen use during pregnancy and offspring attention deficit hyperactivity disorder - a longitudinal sibling control study 

      Gustavson, Kristin; Ystrøm, Eivind; Ask, Helga; Torvik, Fartein Ask; Hornig, Mady; Susser, Ezra; Lipkin, Ian; Lupattelli, Angela; Stoltenberg, Camilla; Magnus, Per Minor; Mjaaland, Siri; Askeland, Ragna Bugge; Walle, Kjersti Mæhlum; Bresnahan, Michaeline; Nordeng, Hedvig Marie Egeland; Reichborn-Kjennerud, Ted (Journal article, 2021)
      Background: Maternal acetaminophen use during pregnancy is associated with increased risk of ADHD in the child. This could reflect causal influence of acetaminophen on fetal neurodevelopment or could be due to confounding ...

    • AChR antibodies show a complex interaction with human skeletal muscle cells in a transcriptomic study 

      Hong, Yu; Liang, Kristina Xiao; Gilhus, Nils Erik (Journal article; Peer reviewed, 2020-07-08)
      Acetylcholine receptor (AChR) antibodies are the most important pathogenic marker in patients with myasthenia gravis (MG). The antibodies bind to AChRs on the postsynaptic membrane, and this leads to receptor degradation, ...

    • Acidification of the Nordic Seas 

      Fransner, Sara Filippa Krusmynta; Fröb, Friederike; Tjiputra, Jerry; Goris, Nadine; Lauvset, Siv Kari; Skjelvan, Ingunn; Jeansson, Emil; Omar, Abdirahman; Chierici, Melissa; Jones, Elizabeth Marie; Fransson, Agneta; Ólafsdóttir, Sólveig R.; Johannessen, Truls; Olsen, Are (Journal article; Peer reviewed, 2022)
      Due to low calcium carbonate saturation states, and winter mixing that brings anthropogenic carbon to the deep ocean, the Nordic Seas and their cold-water corals are vulnerable to ocean acidification. Here, we present a ...

    • ACL Reconstruction Patients Have Increased Risk of Knee Arthroplasty at 15 Years of Follow-up : Data from the Norwegian Knee Ligament Register and the Norwegian Arthroplasty Register from 2004 to 2020 

      Visnes, Håvard; Gifstad, Tone; Persson, Andreas; Lygre, Stein Håkon Låstad; Engebretsen, Lars; Drogset, Jon Olav; Furnes, Ove Nord (Journal article; Peer reviewed, 2022)
      Background: Anterior cruciate ligament (ACL) injury is considered a risk factor for osteoarthritis. The primary aim of the present study was to investigate the cumulative risk of, and risk factors associated with, a ...

    • Acoustic Delicing of Atlantic Salmon (Salmo salar): Fish Welfare and Salmon Lice (Lepeophtheirus salmonis) Dynamics 

      Hjelle, Bibbi Maria Kallay; Imsland, Albert; Vigo, Pablo Balseiro; Handeland, Sigurd Olav (Journal article; Peer reviewed, 2022)
      Acoustic lice treatment (AcuLice) is a newly developed system, which uses a composite acoustic sound image with low-frequency sound to remove salmon lice (Lepeophtheirus salmonis) from Atlantic salmon (Salmo salar). This ...

    • Acoustic pharyngometry - A new method to facilitate oral appliance therapy 

      Opsahl, Ulrik Leidland; Berge, Morten Eirik; Lehmann, Sverre; Bjorvatn, Bjørn; Opsahl, Per; Johansson, Anders (Journal article; Peer reviewed, 2021)
      Background There is lack of reliable and accurate methods to predict treatment outcomes of oral appliance (OA) treatment. Acoustic pharyngometry (AP) is a non-invasive technique to evaluate the volume and minimal ...

    • Acoustic telemetry predation sensors reveal the tribulations of Atlantic salmon (Salmo salar) smolts migrating through lakes 

      Hanssen, Erlend Mjelde; Vollset, Knut Wiik; Salvanes, Anne Gro Vea; Barlaup, Bjørn; Whoriskey, Kim; Isaksen, Trond Einar; Normann, Eirik Straume; Hulbak, Magnus Andre; Lennox, Robert (Journal article; Peer reviewed, 2021)
      Smolt migration through lakes is hazardous, as the predation pressure can be extreme and the hydrology a great contrast to that of a riverine area. However, the mechanisms yielding these challenges have been scarcely ...

    • Actigraphy assessment of motor activity and sleep in patients with alcohol withdrawal syndrome and the effects of intranasal oxytocin 

      Melby, Katrine; Fasmer, Ole Bernt; Henriksen, Tone Elise Gjøtterud; Gråwe, Rolf W.; Aamo, Trond Oskar; Spigset, Olav (Journal article; Peer reviewed, 2020)
      Background and aims The alcohol withdrawal syndrome increases autonomic activation and stress in patients during detoxification, leading to alterations in motor activity and sleep irregularities. Intranasal oxytocin has ...

    • An Actigraphy-Based Validation Study of the Sleep Disorder Inventory in the Nursing Home 

      Hjetland, Gunnhild Johnsen; Nordhus, Inger Hilde; Pallesen, Ståle; Cummings, Jeffrey; Tractenberg, Rochelle E.; Thun, Eirunn; Kolberg, Eirin; Flo, Elisabeth (Journal article; Peer reviewed, 2020-03-13)
      Background: Disrupted sleep is common among nursing home patients with dementia and is associated with increased agitation, depression, and cognitive impairment. Detecting and treating sleep problems in this population are ...

    • Actions on sustainable food production and consumption for the post-2020 global biodiversity framework 

      Delabre, Izabela; Rodriguez, Lily O.; Smallwood, Joanna Miller; Scharlemann, Jörn P.W.; Alcamo, Joseph; Antonarakis, Alexander S.; Rowhani, Pedram; Hazell, Richard J.; Aksnes, Dag Lorents; Balvanera, Patricia; Lundquist, Carolyn J.; Gresham, Charlotte; Alexander, Anthony E.; Stenseth, Nils Christian (Journal article; Peer reviewed, 2021)
      Current food production and consumption trends are inconsistent with the Convention on Biological Diversity’s 2050 vision of living in harmony with nature. Here, we examine how, and under what conditions, the post-2020 ...

    • Activated factor XI-antithrombin complex presenting as an independent predictor of 30-days mortality in out-of-hospital cardiac arrest patients 

      Aarsetøy, Reidun; ten Cate, Hugo; Spronk, Henri; Van Oerle, Rene; Aarsetøy, Hildegunn; Staines, Harry; Nilsen, Dennis W.T. (Journal article; Peer reviewed, 2021)
      Background Cardiac arrest and cardiopulmonary resuscitation (CPR) are associated with activated coagulation and microvascular fibrin deposition with subsequent multiorgan failure and adverse outcome. Objectives Activated ...

    • Activation mechanism and activity of globupain, a thermostable C11 protease from the Arctic Mid-Ocean Ridge hydrothermal system 

      Røyseth, Victoria; M. Hurysz, Brianna; Kaczorowska, Anna-Karina; Dorawa, Sebastian; Fedøy, Anita-Elin; Arsin, Hasan; Sá M. Serafim, Mateus; A. Myers, Samuel; Werbowy, Olesia; Kaczorowski, Tadeusz; Stokke, Runar; O'Donoghue, Anthony J.; Steen, Ida Helene (Journal article; Peer reviewed, 2023)
      Deep-sea hydrothermal vents offer unique habitats for heat tolerant enzymes with potential new enzymatic properties. Here, we present the novel C11 protease globupain, which was prospected from a metagenome-assembled genome ...