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    • A prospective study of pulmonary outcomes and chest computed tomography in the first year after COVID-19 

      Lerum, Tøri Vigeland; Meltzer, Carin; Rivero, Jezabel Rodriguez; Aaløkken, Trond Mogens; Brønstad, Eivind; Aarli, Bernt Bøgvald; Lund, Kristine Marie Aarberg; Durheim, Michael Thomas; Ashraf, Haseem; Einvik, Gunnar; Skjønsberg, Ole Henning; Stavem, Knut (Journal article; Peer reviewed, 2023)
      COVID-19 primarily affects the respiratory system. We aimed to evaluate how pulmonary outcomes develop after COVID-19 by assessing participants from the first pandemic wave prospectively 3 and 12 months following hospital ...

    • Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Surgical Procedures, Complications, and Postoperative Outcomes 

      Teklemariam, Tsegazeab Laeke; Aklilu, Abenezer Tirsit; Kassahun, Azarias; Sahlu, Abat; Yesehak, Betelehem; Getahun, Samuel; Zenebe, Eyob; Deyassa, Negussie; Moen, Bente Elisabeth; Lund-Johansen, Morten; Sundstrøm, Terje (Journal article; Peer reviewed, 2021)
      Background Traumatic brain injury (TBI) is an important cause of trauma-related mortality and morbidity in Ethiopia. There are significant resource limitations along the entire continuum of care, and little is known about ...

    • Prospective Study of Surgery for Traumatic Brain Injury in Addis Ababa, Ethiopia: Trauma Causes, Injury Types, and Clinical Presentation 

      Teklemariam, Tsegazeab Laeke; Aklilu, Abenezer Tirsit; Kassahun, Azarias; Sahlu, Abat; Debebe, Tequam; Yesehak, Betelehem; Masresha, Samuel; Deyassa, Negussie; Moen, Bente Elisabeth; Lund-Johansen, Morten; Sundstrøm, Terje (Journal article; Peer reviewed, 2021)
      Background Traumatic brain injury (TBI) is a public health problem in Ethiopia. More knowledge about the epidemiology and neurosurgical management of TBI patients is needed to identify possible focus areas for quality ...

    • A prospective study on cancer risk after total hip replacements for 41,402 patients linked to the Cancer registry of Norway 

      Dybvik, Eva Hansen; Furnes, Ove; Havelin, Leif Ivar; Fosså, Sophie Dorothea; Trovik, Clement; Lie, Stein Atle (Journal article; Peer reviewed, 2020)
      Background Concerns have been raised that implants used in total hip replacements (THR) could lead to increased cancer risk. Several different materials, metals and fixation techniques are used in joint prostheses and ...

    • A prospective study on the role of smoking, environmental tobacco smoke, indoor painting and living in old or new buildings on asthma, rhinitis and respiratory symptoms 

      Wang, Juan; Janson, Christer; Jõgi, Rain; Forsberg, Bertil; Gíslason, Þórarinn; Holm, Mathias; Torén, Kjell; Malinovschi, Andrei; Sigsgaard, Torben; Schlünssen, Vivi; Svanes, Cecilie; Johannessen, Ane; Bertelsen, Randi Jacobsen; Franklin, Karl A.; Norbäck, Dan (Journal article; Peer reviewed, 2021)
      We studied associations between tobacco smoke, home environment and respiratory health in a 10 year follow up of a cohort of 11,506 adults in Northern Europe. Multilevel logistic regression models were applied to estimate ...

    • Prospects and challenges in the development of universal influenza vaccines 

      Madsen, Anders; Brokstad, Rebecca Jane Cox (Journal article; Peer reviewed, 2020-07-06)
      Current influenza vaccines offer suboptimal protection and depend on annual reformulation and yearly administration. Vaccine technology has rapidly advanced during the last decade, facilitating development of next-generation ...

    • Proteasome‐mediated regulation of GATA2 expression and androgen receptor transcription in benign prostate epithelial cells 

      Azeem, Waqas; Olsen, Jan Roger; Hellem, Margrete Reime; Hua, Yaping; Marvyin, Kristo; Ke, Xisong; Øyan, Anne Margrete; Kalland, Karl Henning (Journal article; Peer reviewed, 2022)
      GATA2 has been shown to be an important transcription factor together with androgen receptor (AR) in prostate cancer cells. Less is known about GATA2 in benign prostate epithelial cells. We have investigated if GATA2 ...

    • Protected sampling is preferable in bronchoscopic studies of the airway microbiome 

      Grønseth, Rune; Drengenes, Christine; Wiker, Harald G; Tangedal, Solveig; Xue, Yaxin; Husebø, Gunnar; Svanes, Øistein; Lehmann, Sverre; Aardal, Marit Elisabeth; Hoang, Tuyen; Kalananthan, Tharmini; Martinsen, Einar Marius Hjellestad; Leiten, Elise Orvedal; Aanerud, Marianne; Nordeide, Eli; Haaland, Ingvild; Jonassen, Inge; Bakke, Per S.; Eagan, Tomas Mikal (Journal article; Peer reviewed, 2017)
      The aim was to evaluate susceptibility of oropharyngeal contamination with various bronchoscopic sampling techniques. 67 patients with obstructive lung disease and 58 control subjects underwent bronchoscopy with ...

    • Protecting essential health services in low-income and middle-income countries and humanitarian settings while responding to the COVID-19 pandemic 

      Blanchet, Karl; Alwan, Ala; Antoine, Caroline; Cros, Marion Jane; Feroz, Ferozuddin; Amsalu Guracha, Tseguaneh; Haaland, Øystein Ariansen; Hailu, Alemayehu; Hangoma, Peter; Jamison, Dean T.; Memirie, Solomon Tessema; Miljeteig, Ingrid; Jan Naeem, Ahmad; Nam, Sara L.; Norheim, Ole Frithjof; Verguet, Stéphane; Watkins, David; Johansson, Kjell Arne (Journal article; Peer reviewed, 2020)
      In health outcomes terms, the poorest countries stand to lose the most from these disruptions. In this paper, we make the case for a rational approach to public sector health spending and decision making during and in the ...

    • Protein Enrichment of Wheat Bread with Microalgae: Microchloropsis gaditana, Tetraselmis chui and Chlorella vulgaris 

      Qazi, Waqas Muhammad; Ballance, Simon; Kousoulaki, Katerina; Uhlen, Anne Kjersti; Kleinegris, Dorinde Mechtilde Meike; Skjånes, Kari; Rieder, Anne (Journal article; Peer reviewed, 2021)
      Cell wall disrupted and dried Microchloropsis gaditana (Mg), Tetraselmis chui (Tc) and Chlorella vulgaris (Cv) microalgae biomasses, with or without ethanol pre‐treatment, were added to wheat bread at a wheat flour ...

    • Protein intake in children and growth and risk of overweight or obesity: A systematic review and meta-analysis 

      Arnesen, Erik Kristoffer; Thorisdottir, Birna; Lamberg-Allardt, Christel; Bärebring, Linnea; Nwaru, Bright; Dierkes, Jutta; Ramel, Alfons; Åkesson, Agneta (Journal article; Peer reviewed, 2022)
      Objectives: The aim of this study was to examine the evidence for an association between the dietary protein intake in children and the growth and risk of overweight or obesity up to 18 years of age in settings relevant ...

    • Protein target highlights in CASP15: Analysis of models by structure providers 

      Alexander, Leila T.; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A.; Bayo, Yusupha; Bhabha, Gira; Breyton, Cécile; Caulton, Simon G.; Chen, James; Degroux, Séraphine; Ekiert, Damian C.; Erlandsen, Benedikte S.; Freddolino, Peter L.; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M.; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D.; Hitchman, Charlie J.; Keown, Jeremy R.; Kropp, Ashleigh; Kursula, Petri Tapani; Lovering, Andrew L.; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markusson, Sigurbjörn; Miller, Mitchell D.; Minasov, George; Niemann, Hartmut H.; Opazo, Felipe; Phillips, George N.; Davies, Owen R.; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A.; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z. Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John; Schwede, Torsten (Journal article; Peer reviewed, 2023)
      We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively ...

    • Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease 

      Khramova, Alina; Boi, Roberto; Fridén, Vincent; Granqvist, Anna Björnson; Nilsson, Ulf; Tenstad, Olav; Oveland, Eystein; Haraldsson, Börje; Ebefors, Kerstin; Nyström, Jenny (Journal article; Peer reviewed, 2021)
      All capillary endothelia, including those of the glomeruli, have a luminal cell surface layer (ESL) consisting of glycoproteins, glycolipids, proteoglycans (PGs) and glycosaminoglycans. Previous results have demonstrated ...

    • Proteome and Phosphoproteome Changes Associated with Prognosis in Acute Myeloid Leukemia 

      Aasebø, Elise; Berven, Frode; Bartaula-Brevik, Sushma; Stokowy, Tomasz; Hovland, Randi; Vaudel, Marc; Døskeland, Stein Ove; Mc Cormack, Emmet; Batth, Tanveer S; Olsen, Jesper V; Bruserud, Øystein; Selheim, Frode; Hernandez-Valladares, Maria (Journal article; Peer reviewed, 2020)
      Acute myeloid leukemia (AML) is a hematological cancer that mainly affects the elderly. Although complete remission (CR) is achieved for the majority of the patients after induction and consolidation therapies, nearly ...

    • Proteomic Analysis of Mesenchymal Stromal Cells Secretome in Comparison to Leukocyte- and Platelet-Rich Fibrin 

      Al-Sharabi, Niyaz Abdulbaqi Abdulmajid; Gruber, Reinhard; Sanz, Mariano; Mohamed-Ahmed, Samih Salah Eldin Mahgoub; Kristoffersen, Einar Klæboe; Mustafa, Kamal Babikeir Elnour; Shanbhag, Siddharth (Journal article; Peer reviewed, 2023)
      Secretomes of mesenchymal stromal cells (MSCs) are emerging as a novel growth factor (GF)-based strategy for periodontal and bone regeneration. The objective of this study was to compare the secretome of human bone marrow ...

    • Proteomic analysis of peripheral blood mononuclear cells isolated from patients with pulmonary tuberculosis: A pilot study from Zanzibar, Tanzania 

      Barakat, Ahmed Samy Mohamed Ali; Birkeland, Even; Jørstad, Melissa Davidsen; el Hajj, Magalie; Marijani, Msafiri; Døskeland, Anne Marie Simonne; Mjaavatten, Olav; Berven, Frode Steingrimsen; Mustafa, Tehmina (Journal article; Peer reviewed, 2023)
      This study aimed at exploring the proteomic profile of PBMCs to predict treatment response in pulmonary tuberculosis (PTB). This was a pilot study conducted among 8 adult patients from Zanzibar, Tanzania with confirmed ...

    • Proteomic Analysis of Zebrafish Protein Recoding via mRNA Editing by ADAR Enzymes 

      Nasaev, Shamsudin S.; Kopeykina, Anna S.; Kuznetsova, Ksenia; Levitsky, Lev I.; Moshkovskii, Sergei A. (Journal article; Peer reviewed, 2022)
      RNA editing by adenosine deaminases of the ADAR family can lead to protein recoding, since inosine formed from adenosine in mRNA is complementary to cytosine; the resulting codon editing might introduce amino acid substitutions ...

    • Proteomic analysis unveils Gb3-independent alterations and mitochondrial dysfunction in a gla−/− zebrafish model of Fabry disease 

      Elsaid, Hassan Osman Alhassan; Rivedal, Mariell Lossius; Skandalou, Eleni; Svarstad, Einar; Tøndel, Camilla; Birkeland, Even; Eikrem, Øystein Solberg; Babickova, Janka; Marti, Hans Peter; Furriol, Jessica (Journal article; Peer reviewed, 2023)
      Background Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations in the GLA gene, resulting in reduced or lack of α-galactosidase A activity. This results in the accumulation of globotriaosylceramide ...

    • Proteomic Comparison of Bone Marrow Derived Osteoblasts and Mesenchymal Stem Cells 

      Aasebø, Elise; Brenner, Annette; Hernandez-Valladares, Maria; Birkeland, Even; Berven, Frode Steingrimsen; Selheim, Frode; Bruserud, Øystein (Journal article; Peer reviewed, 2021)
      Mesenchymal stem cells (MSCs) can differentiate into osteoblasts, and therapeutic targeting of these cells is considered both for malignant and non-malignant diseases. We analyzed global proteomic profiles for osteoblasts ...

    • Proteomic signature of tubulointerstitial tissue predicts prognosis in IgAN 

      Paunas, Flavia Teodora Ioana; Finne, Kenneth; Leh, Sabine; Marti, Hans Peter; Berven, Frode Steingrimsen; Vikse, Bjørn Egil (Journal article; Peer reviewed, 2022-03-24)
      Background: IgA nephropathy (IgAN) is associated with a significant risk of progression to kidney failure. Tubular atrophy is an established important risk factor for progressive disease, but few studies have investigated ...