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dc.contributor.authorBielecka-Dabrowa, Agataen_US
dc.contributor.authorMichalska-Kasiczak, Martaen_US
dc.contributor.authorGluba, Annaen_US
dc.contributor.authorAhmed, Alien_US
dc.contributor.authorGerdts, Evaen_US
dc.contributor.authorvon Haehling, Stephanen_US
dc.contributor.authorRysz, Jaceken_US
dc.contributor.authorBanach, Maciejen_US
dc.date.accessioned2016-03-16T10:48:14Z
dc.date.available2016-03-16T10:48:14Z
dc.date.issued2015-03-09
dc.PublishedScientific Reports 2015, 5:8916eng
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/1956/11673
dc.description.abstractThe study aimed to identify early echocardiographic and circulating biomarkers of heart failure (HF) in hypertensive patients with normal resting echocardiography. Echocardiography at rest and during exercise, and selected biomarkers were assessed in control group, dyspnea group, and HF group. On exercise dyspnea patients had lower early diastolic (E') and systolic (S') mitral annular velocity (12.8 ± 1.0 vs 14.9 ± 3.0 cm/sec and 9.3 ± 2.0 vs 10.9 ± 2.0 cm/sec, respectively), and higher E/E' ratio compared to control group (6.7 ± 1.0 vs 5.9 ± 1.0) (p < 0.05 for all comparisons). The level of N-terminal propeptide of procollagen type III (PIIINP) was significantly higher in dyspnea group than in controls (p = 0.01). Control and dyspnea patients had lower levels of cardiotrophin-1, cystatin C, syndecan-4, and N terminal–probrain natriuretic peptide than HF patients (all p ≤ 0.01). In multivariate analysis PIIINP (unadjusted odds ratio [OR] = 8.2, 95% confidence interval [Cl] 1.7–40.6; p = 0.001; adjusted OR = 8.7; 95%CI: 1.5–48.3; p = 0.001) and E/E' ratio on exercise (unadjusted OR = 1.8, 95%CI: 0.8–4.0; p = 0.033; adjusted OR = 2.0; 95%CI: 0.8–4.8; p = 0.012) were the only factors significantly associated with the presence of dyspnea. PIIINP is the first early biomarker for the HF development in patients with HA and normal resting echocardiography. Exertional echocardiography may indicate patients with incipient HF with preserved ejection fraction.en_US
dc.language.isoengeng
dc.publisherNature Publishing Groupeng
dc.rightsAttribution CC BY 4.0eng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleBiomarkers and echocardiographic predictors of myocardial dysfunction in patients with hypertensionen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2015-12-30T17:02:55Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright the authors
dc.identifier.doihttps://doi.org/10.1038/srep08916
dc.identifier.cristin1248186
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Kardiologi: 771
dc.subject.nsiVDP::Midical sciences: 700::Clinical medical sciences: 750::Cardiology: 771
dc.subject.nsiVDP::Medisinske Fag: 700en_US


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