Vis enkel innførsel

dc.contributor.authorØygarden, Halvoren_US
dc.contributor.authorFromm, Annetteen_US
dc.contributor.authorSand, Kristin Modalslien_US
dc.contributor.authorEide, Geir Egilen_US
dc.contributor.authorThomassen, Larsen_US
dc.contributor.authorNæss, Halvoren_US
dc.contributor.authorWaje-Andreassen, Ulrikeen_US
dc.date.accessioned2016-03-21T13:43:30Z
dc.date.available2016-03-21T13:43:30Z
dc.date.issued2016-01
dc.PublishedEuropean Journal of Neurology 2016, 23:154-159eng
dc.identifier.issn1468-1331
dc.identifier.urihttps://hdl.handle.net/1956/11720
dc.description.abstractBackground and purpose: Family history (FH) is used as a marker for inherited risk. Using FH for this purpose requires the FH to reflect true disease in the family. The aim was to analyse the concordance between young and middle-aged ischaemic stroke patients' reported FH of cardiovascular disease (CVD) with their parents' own reports. Methods: Ischaemic stroke patients aged 15–60 years and their eligible parents were interviewed using a standardized questionnaire. Information of own CVD and FH of CVD was registered. Concordance between patients and parents was tested by kappa statistics, sensitivity, specificity, predictive values and likelihood ratios. Regression analyses were performed to identify patient characteristics associated with non-concordance of replies. Results: There was no difference in response rate between fathers and mothers (P = 0.355). Both parents responded in 57 cases. Concordance between patient and parent reports was good, with kappa values ranging from 0.57 to 0.7. The patient-reported FH yielded positive predictive values of 75% or above and negative predictive values of 90% or higher. The positive likelihood ratios (LR+) were 10 or higher and negative likelihood ratios (LR−) were generally 0.5 or lower. Interpretation regarding peripheral arterial disease was limited due to low parental prevalence. Higher age was associated with impaired concordance between patient and parent reports (odds ratio 1.05; 95% confidence interval 1.01–1.09; P = 0.020). Conclusions: The FH provided by young and middle-aged stroke patients is in good concordance with parental reports. FH is an adequate proxy to assess inherited risk of CVD in young stroke patients.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/12079"target="blank">Family history in young and middle-aged acute ischemic stroke patients. The Norwegian Stroke in the Young Study</a>eng
dc.rightsAttribution CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.subjectCardiovascular diseaseeng
dc.subjectfamily historyeng
dc.subjectischaemic strokeeng
dc.subjectverificationeng
dc.subjectyoung strokeeng
dc.titleCan the cardiovascular family history reported by our patients be trusted? The Norwegian Stroke in the Young Studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-02-04T13:46:19Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authors
dc.identifier.doihttps://doi.org/10.1111/ene.12824
dc.identifier.cristin1329176


Tilhørende fil(er)

Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Attribution CC BY-NC
Med mindre annet er angitt, så er denne innførselen lisensiert som Attribution CC BY-NC