Biomarkers related to carotid intima-media thickness and plaques in long-term survivors of ischemic stroke
dc.contributor.author | Waje-Andreassen, Ulrike | en_US |
dc.contributor.author | Næss, Halvor | en_US |
dc.contributor.author | Thomassen, Lars | en_US |
dc.contributor.author | Marøy, Tove Helene | en_US |
dc.contributor.author | Mazengia, Kibret Yimer | en_US |
dc.contributor.author | Eide, Geir Egil | en_US |
dc.contributor.author | Vedeler, Christian A. | en_US |
dc.date.accessioned | 2016-04-01T11:49:09Z | |
dc.date.available | 2016-04-01T11:49:09Z | |
dc.date.issued | 2015-05-08 | |
dc.Published | Translational Stroke Research 2015, 6(4):276-283 | eng |
dc.identifier.issn | 1868-601X | |
dc.identifier.uri | https://hdl.handle.net/1956/11815 | |
dc.description.abstract | Lifestyle risk factors, inflammation and genetics play a role in the development of atherosclerosis. We therefore studied Fc gamma receptor (FcγR) polymorphisms, interleukin (IL)-10 polymorphisms and other biomarkers related to carotid intima-media thickness (cIMT) in patients with ischemic stroke at a young age. Patients were evaluated 12 years after stroke occurrence. Patients (n = 232) 49 years of age or younger with an index stroke between 1988 and 1997 were retrospectively selected. Blood samples were taken at a first follow-up 6 years after the stroke. At a second follow-up, additional arterial events were registered for 140 patients, new blood samples were taken, and measurements of cIMT and blood pressure (BP) were performed. Unadjusted logistic regression analysis showed that cIMT ≥1 mm was associated with age, male gender, additional arterial events, BP, cholesterol, sedimentation rate, haemoglobin, triglycerides, creatinine, glycolysed haemoglobin (HbA1c) and FcγRIIIB-NaII/NaII. Adjusted backward stepwise logistic regression showed significance for age (odds ratio (OR) 1.13, 95 % confidence interval (CI) 1.04 to1.23, p = 0.003), male gender (OR 4.07, 95 % CI 1.15 to 14.5, p = 0.030), HbA1c (OR 6.65, 95 % CI 1.21 to 36.5, p = 0.029) and FcγRIIIB-NaII/NaII (OR 3.94, 95 % CI 1.08 to 14.3, p = 0.037). In this long-term follow-up study of patients with ischemic stroke at a young age, FcγRIIIB-NaII/NaII was identified as a possible contributing factor for cIMT ≥1 mm together with known risk factors, such as age, male gender, systolic BP, additional arterial events and HbA1c. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Springer | eng |
dc.rights | Attribution CC BY 4.0 | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | eng |
dc.subject | Young ischemic stroke | eng |
dc.subject | Long-term follow-up | eng |
dc.subject | Carotid IMT | eng |
dc.subject | Fc gamma receptors | eng |
dc.subject | IL-10 | eng |
dc.subject | HbA1c | eng |
dc.title | Biomarkers related to carotid intima-media thickness and plaques in long-term survivors of ischemic stroke | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2015-11-10T10:00:03Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright The Author(s) 2015 | |
dc.identifier.doi | https://doi.org/10.1007/s12975-015-0403-0 | |
dc.identifier.cristin | 1248178 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752 | |
dc.subject.nsi | VDP::Midical sciences: 700::Clinical medical sciences: 750::Neurology: 752 | |
dc.subject.nsi | VDP::Medisinske Fag: 700 | en_US |