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dc.contributor.authorHordvik, Ivar
dc.date.accessioned2016-04-14T12:23:28Z
dc.date.available2016-04-14T12:23:28Z
dc.date.issued2015-02
dc.identifier.citationBiomolecules 2015, 5:166-177eng
dc.identifier.urihttp://hdl.handle.net/1956/11912
dc.description.abstractThere are three major immunoglobulin (Ig) isotypes in salmonid fish: IgM, IgD and IgT, defined by the heavy chains , and , respectively. As a result of whole genome duplication in the ancestor of the salmonid fish family, Atlantic salmon (Salmo salar) possess two highly similar Ig heavy chain gene complexes (A and B), comprising two genes, two genes, three intact genes and five pseudogenes. The A and B genes correspond to two distinct sub-populations of serum IgM. The IgM-B sub-variant has a characteristic extra cysteine near the C-terminal part of the heavy chain and exhibits a higher degree of polymer disulfide cross-linking compared to IgM-A. The IgM-B:IgM-A ratio in serum is typically 60:40, but skewed ratios are also observed. The IgT isotype appears to be specialized to mucosal immune responses in salmonid fish. The concentration of IgT in serum is 100 to 1000 times lower than IgM. Secreted forms of IgD have been detected in rainbow trout, but not yet in Atlantic salmon.eng
dc.language.isoengeng
dc.publisherMDPIeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.subjectimmunoglobulineng
dc.subjectIgMeng
dc.subjectIgTeng
dc.subjectAtlantic salmoneng
dc.subjecttetraploidyeng
dc.subjectWGDeng
dc.titleImmunoglobulin Isotypes in Atlantic Salmon, Salmo Salareng
dc.typeJournal articleeng
dc.date.updated2016-03-16T09:16:57Z
dc.rights.holderCopyright 2015 the authorseng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1345078
dc.identifier.doi10.3390/biom5010166eng
dc.source.issn2218-273Xeng
bora.bpoaIDbpoa369


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