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dc.contributor.authorPassow, Susanne
dc.contributor.authorSpecht, Karsten
dc.contributor.authorAdamsen, Tom Christian
dc.contributor.authorBiermann, Martin
dc.contributor.authorBrekke, Njål
dc.contributor.authorCraven, Alexander R.
dc.contributor.authorErsland, Lars
dc.contributor.authorGrüner, Renate
dc.contributor.authorKleven-Madsen, Nina
dc.contributor.authorKvernenes, Ole Heine
dc.contributor.authorSchwarzlmüller, Thomas
dc.contributor.authorOlesen, Rasmus Aamand
dc.contributor.authorHugdahl, Kenneth
dc.date.accessioned2016-05-25T12:32:02Z
dc.date.available2016-05-25T12:32:02Z
dc.date.issued2015-06
dc.PublishedHuman Brain Mapping 2015, 36(6):2027-2038eng
dc.identifier.issn1097-0193
dc.identifier.urihttp://hdl.handle.net/1956/12005
dc.description.abstractOver the last decade, the brain's default-mode network (DMN) and its function has attracted a lot of attention in the field of neuroscience. However, the exact underlying mechanisms of DMN functional connectivity, or more specifically, the blood-oxygen level-dependent (BOLD) signal, are still incompletely understood. In the present study, we combined 2-deoxy-2-[18F]fluoroglucose positron emission tomography (FDG-PET), proton magnetic resonance spectroscopy (1H-MRS), and resting-state functional magnetic resonance imaging (rs-fMRI) to investigate more directly the association between local glucose consumption, local glutamatergic neurotransmission and DMN functional connectivity during rest. The results of the correlation analyzes using the dorsal posterior cingulate cortex (dPCC) as seed region showed spatial similarities between fluctuations in FDG-uptake and fluctuations in BOLD signal. More specifically, in both modalities the same DMN areas in the inferior parietal lobe, angular gyrus, precuneus, middle, and medial frontal gyrus were positively correlated with the dPCC. Furthermore, we could demonstrate that local glucose consumption in the medial frontal gyrus, PCC and left angular gyrus was associated with functional connectivity within the DMN. We did not, however, find a relationship between glutamatergic neurotransmission and functional connectivity. In line with very recent findings, our results lend further support for a close association between local metabolic activity and functional connectivity and provide further insights towards a better understanding of the underlying mechanism of the BOLD signal.en_US
dc.language.isoengeng
dc.publisherWileyeng
dc.rightsCopyright 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.eng
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/eng
dc.subjectFDG-PETeng
dc.subjectresting-state fMRIeng
dc.subject1H-MR spectroscopyeng
dc.subjectdefault-mode networkeng
dc.subjectresting-state functional connectivityeng
dc.titleDefault-mode network functional connectivity is closely related to metabolic activityeng
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-03-23T08:45:20Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright The Authors.eng
dc.identifier.doihttps://doi.org/10.1002/hbm.22753
dc.identifier.cristin1219814
dc.subject.nsiVDP::Medisinske fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752


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Copyright 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
Med mindre annet er angitt, så er denne innførselen lisensiert som Copyright 2015 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.