Show simple item record

dc.contributor.authorLysne, Vegard
dc.contributor.authorBjørndal, Bodil
dc.contributor.authorVik, Rita
dc.contributor.authorNordrehaug, Jan Erik
dc.contributor.authorSkorve, Jon
dc.contributor.authorNygård, Ottar
dc.contributor.authorBerge, Rolf Kristian
dc.date.accessioned2016-08-02T11:46:48Z
dc.date.available2016-08-02T11:46:48Z
dc.date.issued2015-06-04
dc.identifier.citationNutrients 2015, 7(6):4498-4511eng
dc.identifier.urihttp://hdl.handle.net/1956/12390
dc.description.abstractThe present study aimed to evaluate effects of a water-soluble protein fraction of chicken (CP), with a low methionine/glycine ratio, on plasma homocysteine and metabolites related to homocysteine metabolism. Male Wistar rats were fed either a control diet with 20% w/w casein as the protein source, or an experimental diet where 6, 14 or 20% w/w of the casein was replaced with the same amount of CP for four weeks. Rats fed CP had reduced plasma total homocysteine level and markedly increased levels of the choline pathway metabolites betaine, dimethylglycine, sarcosine, glycine and serine, as well as the transsulfuration pathway metabolites cystathionine and cysteine. Hepatic mRNA level of enzymes involved in homocysteine remethylation, methionine synthase and betaine-homocysteine S-methyltransferase, were unchanged, whereas cystathionine gamma-lyase of the transsulfuration pathway was increased in the CP treated rats. Plasma concentrations of vitamin B2, folate, cobalamin, and the B-6 catabolite pyridoxic acid were increased in the 20% CP-treated rats. In conclusion, the CP diet was associated with lower plasma homocysteine concentration and higher levels of serine, choline oxidation and transsulfuration metabolites compared to a casein diet. The status of related B-vitamins was also affected by CP.eng
dc.language.isoengeng
dc.publisherMDPIeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectchicken proteineng
dc.subjecthomocysteineeng
dc.subjectone-carbon metabolismeng
dc.subjectperoxisome proliferator activated receptoreng
dc.subjectWistar ratseng
dc.titleA protein extract from chicken reduces plasma homocysteine in ratseng
dc.typeJournal articleeng
dc.subject.nsiVDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811
dc.subject.nsiVDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811
dc.subject.nsiVDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716
dc.subject.nsiVDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716
dc.date.updated2016-04-11T12:16:22Z
dc.rights.holderCopyright 2015 The Authorseng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1254299
dc.identifier.doi10.3390/nu7064498eng
dc.source.issn2072-6643eng


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY