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dc.contributor.authorHjørnevik, Linda Veka
dc.contributor.authorFrøyset, Ann Kristin
dc.contributor.authorGrønset, Toril Anne
dc.contributor.authorRungruangsak-Torrissen, Krisna
dc.contributor.authorFladmark, Kari Espolin
dc.date.accessioned2016-08-08T12:43:02Z
dc.date.available2016-08-08T12:43:02Z
dc.date.issued2015-12-14
dc.PublishedMarine Drugs 2015, 13(12):7390-7402eng
dc.identifier.issn1660-3397en_US
dc.identifier.urihttps://hdl.handle.net/1956/12494
dc.description.abstractAzaspiracid-1 is an algal toxin that accumulates in edible mussels, and ingestion may result in human illness as manifested by vomiting and diarrhoea. When injected into mice, it causes neurotoxicological symptoms and death. Although it is well known that azaspiracid-1 is toxic to most cells and cell lines, little is known about its biological target(s). A rat PC12 cell line, commonly used as a model for the peripheral nervous system, was used to study the neurotoxicological effects of azaspiracid-1. Azaspiracid-1 induced differentiation-related morphological changes followed by a latter cell death. The differentiated phenotype showed peripherin-labelled neurite-like processes simultaneously as a specific isoform of peripherin was down-regulated. The precise mechanism behind this down-regulation remains uncertain. However, this study provides new insights into the neurological effects of azaspiracid-1 and into the biological significance of specific isoforms of peripherin.en_US
dc.language.isoengeng
dc.publisherMDPIen_US
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectazaspiracideng
dc.subjectalgal toxineng
dc.subjectneurotoxineng
dc.subjectperipherineng
dc.subjectintermediate filamenteng
dc.subjectisoformeng
dc.subjectPC12 cellseng
dc.titleAlgal toxin azaspiracid-1 induces early neuronal differentiation and alters peripherin isoform stoichiometryen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-04-08T11:23:39Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2015 The Authorsen_US
dc.identifier.doihttps://doi.org/10.3390/md13127072
dc.identifier.cristin1300675


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