dc.contributor.author | Ramsvik, Marie Sannes | en_US |
dc.contributor.author | Bjørndal, Bodil | en_US |
dc.contributor.author | Bruheim, Inge | en_US |
dc.contributor.author | Bohov, Pavol | en_US |
dc.contributor.author | Berge, Rolf Kristian | en_US |
dc.date.accessioned | 2016-08-09T06:38:02Z | |
dc.date.available | 2016-08-09T06:38:02Z | |
dc.date.issued | 2015-07-16 | |
dc.Published | Marine Drugs 2015, 13(7):4375-4397 | eng |
dc.identifier.issn | 1660-3397 | |
dc.identifier.uri | https://hdl.handle.net/1956/12496 | |
dc.description.abstract | Dietary intake of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) can change the plasma profile from atherogenic to cardioprotective. In addition, there is growing evidence that proteins of marine origin may have health benefits. We investigated a phospholipid-protein complex (PPC) from krill that is hypothesized to influence lipid metabolism, inflammation, and redox status. Male Wistar rats were fed a control diet (2% soy oil, 8% lard, 20% casein), or diets where corresponding amounts of casein and lard were replaced with PPC at 3%, 6%, or 11% (wt %), for four weeks. Dietary supplementation with PPC resulted in significantly lower levels of plasma triacylglycerols in the 11% PPC-fed group, probably due to reduced hepatic lipogenesis. Plasma cholesterol levels were also reduced at the highest dose of PPC. In addition, the plasma and liver content of n-3 PUFAs increased while n-6 PUFAs decreased. This was associated with increased total antioxidant capacity in plasma and increased liver gene expression of mitochondrial superoxide dismutase (Sod2). Finally, a reduced plasma level of the inflammatory mediator interleukin-2 (IL-2) was detected in the PPC-fed animals. The present data show that PPC has lipid-lowering effects in rats, and may modulate risk factors related to cardiovascular disease progression. | en_US |
dc.language.iso | eng | eng |
dc.publisher | MDPI | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject | Antarctic krill | eng |
dc.subject | lipogenesis | eng |
dc.subject | plasma lipids | eng |
dc.subject | Inflammation | eng |
dc.subject | antioxidant capacity | eng |
dc.subject | Omega-3 polyunsaturated fatty acids | eng |
dc.subject | cholesterol | eng |
dc.subject | lipid lowering | eng |
dc.title | A phospholipid-protein complex from krill with antioxidative and immunomodulating properties reduced plasma triacylglycerol and hepatic lipogenesis in rats | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2016-04-08T11:22:15Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2015 by the authors | |
dc.identifier.doi | https://doi.org/10.3390/md13074375 | |
dc.identifier.cristin | 1267069 | |
dc.subject.nsi | VDP::Medisinske fag: 700::Helsefag: 800::Ernæring: 811 | |
dc.subject.nsi | VDP::Midical sciences: 700::Health sciences: 800::Nutrition: 811 | |