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dc.contributor.authorRisnes, Kari Ravndalen_US
dc.contributor.authorPape, Kristineen_US
dc.contributor.authorBjørngaard, Johan Håkonen_US
dc.contributor.authorMoster, Dagen_US
dc.contributor.authorBracken, Michael Ben_US
dc.contributor.authorRomundstad, Pål Richarden_US
dc.date.accessioned2016-12-12T13:48:17Z
dc.date.available2016-12-12T13:48:17Z
dc.date.issued2016-11-07
dc.PublishedPLoS ONE 2016, 11(11):e0165051eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/15236
dc.description.abstractBackground: Close to one in ten individuals worldwide is born preterm, and it is important to understand patterns of long-term health and mortality in this group. This study assesses the relationship between gestational age at birth and early adult mortality both in a nationwide population and within sibships. The study adds to existing knowledge by addressing selected causes of death and by assessing the role of genetic and environmental factors shared by siblings. Methods: Study population was all Norwegian men and women born from 1967 to 1997 followed using nation-wide registry linkage for mortality through 2011 when they were between 15 and 45 years of age. Analyses were performed within maternal sibships to reduce variation in unobserved genetic and environmental factors shared by siblings. Specific outcomes were all-cause mortality and mortality from cardiovascular diseases, cancer and external causes including accidents, suicides and drug abuse/overdoses. Results: Compared with a sibling born in week 37–41, preterm siblings born before 34 weeks gestation had 50% increased mortality from all causes (adjusted Hazard Ratio (aHR) 1.54, 95% confidence interval (CI) 1.17, 2.03). The corresponding estimate for the entire population was 1.27 (95% CI 1.09, 1.47). The majority of deaths (65%) were from external causes and the corresponding risk estimates for these deaths were 1.52 (95% CI 1.08, 2.14) in the sibships and 1.20 (95% CI 1.01, 1.43) in the population. Conclusion: Preterm birth before week 34 was associated with increased mortality between 15 and 45 years of age. The results suggest that increased premature adult mortality in this group is related to external causes of death and that the increased risks are unlikely to be explained by factors shared by siblings.en_US
dc.language.isoengeng
dc.publisherPLOSeng
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5098830/pdf/pone.0165051.pdf
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titlePremature Adult Death in Individuals Born Preterm: A Sibling Comparison in a Prospective Nationwide Follow-Up Studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2016-11-21T08:47:20Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0165051
dc.identifier.cristin1402206


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