dc.contributor.author | Holst, Frederik | en_US |
dc.contributor.author | Høivik, Erling Andre | en_US |
dc.contributor.author | Gibson, William J. | en_US |
dc.contributor.author | Taylor-Weiner, Amaro | en_US |
dc.contributor.author | Schumacher, Steven E. | en_US |
dc.contributor.author | Asmann, Yan W. | en_US |
dc.contributor.author | Grossmann, Patrick | en_US |
dc.contributor.author | Trovik, Jone | en_US |
dc.contributor.author | Necela, Brian M. | en_US |
dc.contributor.author | Thompson, E. Aubrey | en_US |
dc.contributor.author | Meyerson, Matthew | en_US |
dc.contributor.author | Beroukhim, Rameen | en_US |
dc.contributor.author | Salvesen, Helga Birgitte | en_US |
dc.contributor.author | Cherniack, Andrew D. | en_US |
dc.date.accessioned | 2017-01-12T13:18:05Z | |
dc.date.available | 2017-01-12T13:18:05Z | |
dc.date.issued | 2016-05-10 | |
dc.Published | Scientific Reports 2016, 6:25521 | eng |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | https://hdl.handle.net/1956/15360 | |
dc.description.abstract | The estrogen receptor alpha (ERα) is highly expressed in both endometrial and breast cancers, and represents the most prevalent therapeutic target in breast cancer. However, anti-estrogen therapy has not been shown to be effective in endometrial cancer. Recently it has been shown that hormone-binding domain alterations of ERα in breast cancer contribute to acquired resistance to anti-estrogen therapy. In analyses of genomic data from The Cancer Genome Atlas (TCGA), we observe that endometrial carcinomas manifest recurrent ESR1 gene amplifications that truncate the hormone-binding domain encoding region of ESR1 and are associated with reduced mRNA expression of exons encoding the hormone-binding domain. These findings support a role for hormone-binding alterations of ERα in primary endometrial cancer, with potentially important therapeutic implications. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Nature Publishing Group | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | eng |
dc.title | Recurrent hormone-binding domain truncated ESR1 amplifications in primary endometrial cancers suggest their implication in hormone independent growth | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2016-12-15T10:16:07Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2016 The Author(s) | |
dc.identifier.doi | https://doi.org/10.1038/srep25521 | |
dc.identifier.cristin | 1365441 | |