dc.contributor.author | Gansmo, Liv Beathe | en_US |
dc.contributor.author | Bjørnslett, Merete Pauline | en_US |
dc.contributor.author | Halle, Mari Kyllesø | en_US |
dc.contributor.author | Salvesen, Helga Birgitte | en_US |
dc.contributor.author | Dørum, Anne | en_US |
dc.contributor.author | Birkeland, Einar Elvbakken | en_US |
dc.contributor.author | Hveem, Kristian | en_US |
dc.contributor.author | Romundstad, Pål Richard | en_US |
dc.contributor.author | Vatten, Lars Johan | en_US |
dc.contributor.author | Lønning, Per Eystein | en_US |
dc.contributor.author | Knappskog, Stian | en_US |
dc.date.accessioned | 2017-03-30T13:47:13Z | |
dc.date.available | 2017-03-30T13:47:13Z | |
dc.date.issued | 2016-02-11 | |
dc.Published | Tumour Biology 2016, 37(8):10697-10702 | eng |
dc.identifier.issn | 1010-4283 | |
dc.identifier.uri | https://hdl.handle.net/1956/15623 | |
dc.description.abstract | The MDM4 protein (also known as MDMX or HDMX) is a negative regulator of p53, not only by direct interaction but also through its interaction with MDM2. Further, MDM4 overexpression and amplification have been observed in several cancer forms. Recently, a single nucleotide polymorphism (SNP) in the 3’ untranslated region of the MDM4 gene, SNP34091A > C (rs4245739) was reported to alter MDM4 messenger RNA (mRNA) stability by modulating a microRNA binding site, thereby leading to decreased MDM4 levels. In this case-control study, we aimed to evaluate the possible association between MDM4 SNP34091 status and cancer risk by comparing the genotype frequencies in large hospital-based cohorts of endometrial- (n = 1404) and ovarian (n = 1385) cancer patients with healthy female controls (n = 1870). Genotype frequencies were compared by odds ratio (OR) estimates and Fisher exact tests. We found that individuals harboring the MDM4 SNP34091AC/CC genotypes had a significantly elevated risk for serous ovarian cancer (SOC) in general and high-grade serous ovarian cancer (HGSOC) in particular (SOC: OR = 1.18., 95 % CI = 1.01–1.39; HGSOC: OR = 1.25, CI = 1.02–1.53). No association between SNP34091 genotypes and endometrial cancer risk was observed. Our data indicate the MDM4 SNP34091AC/CC genotypes to be associated with an elevated risk for SOC and in particular the HGSOC type. | en_US |
dc.language.iso | eng | eng |
dc.publisher | Springer | eng |
dc.rights | Attribution CC BY | eng |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | eng |
dc.subject | MDM4 | eng |
dc.subject | SNP34091 | eng |
dc.subject | Cancer risk | eng |
dc.subject | Ovarian cancer | eng |
dc.subject | Endometrial cancer | eng |
dc.title | The MDM4 SNP34091 (rs4245739) C-allele is associated with increased risk of ovarian—but not endometrial cancer | en_US |
dc.type | Peer reviewed | |
dc.type | Journal article | |
dc.date.updated | 2016-12-13T14:15:37Z | |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | Copyright 2016 the authors | |
dc.identifier.doi | https://doi.org/10.1007/s13277-016-4940-2 | |