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dc.contributor.authorRosén, Annika
dc.contributor.authorTardast, Arezo
dc.contributor.authorShi, Tie-Jun
dc.identifier.citationRosén A, Tardast A, Shi T. How Far Have We Come in the Field of Nerve Regeneration After Trigeminal Nerve Injury?. Current Oral Health Reports. 2016;3(4):309-313eng
dc.description.abstractPatients suffering from nerve injury with sensory disturbances or orofacial pain have greatly reduced quality of life, and it is a big cost for the society. Abnormal sensations caused by trigeminal nerve injury often become chronic, severely debilitating, and extremely difficult to treat. In general, non-invasive treatment such as drug treatment has been insufficient, and there are currently few available effective treatments. Surgical interventions such as end-to-end connection or nerve grafting have disadvantages such as donor site morbidity or formation of neuroma. There is need for optimizing the technique for nerve repair, especially for the trigeminal nerve system, which has so far not yet been well explored. Recently, tissue engineering using biodegradable synthetic material and cell-based therapies represents a promising approach to nerve repair and it has been reported that mesenchymal stem cell (MSC) has an anti-inflammatory effect and seems to play an important role in nerve healing and regeneration.eng
dc.rightsAttribution CC BYeng
dc.subjectSensory neuronseng
dc.subjectOrofacial sensory disturbanceseng
dc.subjectTrigeminal nerveeng
dc.subjectInferior alveolar nerveeng
dc.subjectLingual nerveeng
dc.subjectInfraorbital nerveeng
dc.subjectNerve regenerationeng
dc.subjectMesenchymal stem cellseng
dc.subjectAdipose derived stem cellseng
dc.subjectStem cells therapyeng
dc.titleHow Far Have We Come in the Field of Nerve Regeneration After Trigeminal Nerve Injury?eng
dc.typeJournal articleeng
dc.rights.holderCopyright 2016 The Author(s)eng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.relation.journalCurrent Oral Health Reports

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