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dc.contributor.authorBuanes, Eirik Alnes
dc.contributor.authorHufthammer, Karl O.
dc.contributor.authorLangørgen, Jørund
dc.contributor.authorGuttormsen, Anne-Berit
dc.contributor.authorHeltne, Jon-Kenneth
dc.date.accessioned2017-09-08T12:49:22Z
dc.date.available2017-09-08T12:49:22Z
dc.date.issued2017
dc.identifier.urihttp://hdl.handle.net/1956/16621
dc.description.abstractBackground: Targeted temperature management in cardiac arrest was introduced following evidence of increased survival from two controlled trials published in 2002. We wanted to investigate whether the introduction of targeted temperature management to clinical practice had increased the survival of cardiac arrest patients at Haukeland University Hospital, Norway. Methods: We included 336 unresponsive patients admitted to the emergency department between December 2003 and December 2008 with return of spontaneous circulation following out-of-hospital cardiac arrest in the analysis. A propensity score model was developed to evaluate the survival of patients receiving intensive care treatment including targeted temperature management, compared with intensive care treatment not including targeted temperature management. Results: Estimation of the treatment effect revealed an increase of 57 days (95% CI: 12–103, p = 0.01) in restricted mean survival during the first year after cardiac arrest for intensive care treatment including targeted temperature management. Discussion: As with all observational studies, bias is probable. However, propensity score methodology has been used in order to reduce bias and establish causality. Although residual confounding is likely, our interpretation is that TTM increased survival for comatose OHCA patients in our hospital because survival increased well beyond the level of significance. Conclusion: The introduction of targeted temperature management to clinical practice is likely to have increased survival for unresponsive patients following out-of-hospital cardiac arrest.eng
dc.language.isoengeng
dc.publisherBioMed Centraleng
dc.relation.ispartof<a href="http://hdl.handle.net/1956/16620" target="blank">Cardiac Arrest in a Community: Epidemiology, Treatment, and Outcome</a>
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.eng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/eng
dc.subjectCardiac arresteng
dc.subjectOutcomeeng
dc.subjectTargeted temperature managementeng
dc.subjectPropensity score matchingeng
dc.subjectIntensive careeng
dc.titleTargeted temperature management in cardiac arrest: survival evaluated by propensity score matchingeng
dc.typeJournal articleeng
dc.rights.holderCopyright The Author(s)eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleScandinavian Journal of Trauma, Resuscitation and Emergency Medicineeng
bibo.volume25eng
bibo.issue31eng
dc.identifier.doi10.1186/s13049-017-0373-1eng
dc.source.issn1757-7241eng
noa.nsiVDP::Medisinske Fag: 700eng


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This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Except where otherwise noted, this item's license is described as This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.