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dc.contributor.authorWensaas, Knut-Arne
dc.contributor.authorHanevik, Kurt
dc.contributor.authorHausken, Trygve
dc.contributor.authorEide, Geir Egil
dc.contributor.authorLangeland, Nina
dc.contributor.authorMørch, Kristine
dc.contributor.authorRørtveit, Guri
dc.date.accessioned2017-10-09T12:38:51Z
dc.date.available2017-10-09T12:38:51Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/1956/16744
dc.description.abstract<p>Background: Irritable bowel syndrome (IBS) is a common complication following gastroenteritis, and a high prevalence of postgiardiasis IBS has previously been reported. This study aims to investigate the prevalence, adjusted relative risk (RRadj), and overlap of different functional gastrointestinal disorders (FGID) according to Rome III criteria following infection with Giardia lamblia.</p> <p>Methods: All patients ≥18 years of age with verified giardiasis during an outbreak in 2004, and a control group matched by age and gender, were mailed a questionnaire 3 years later.</p> <p>Key Results: The prevalence of functional dyspepsia (FD) was 25.9% in the exposed and 6.9% in the control group, RRadj: 3.9 (95% confidence intervals [CI]: 3.1–4.8). The prevalence of IBS was 47.9% and 14.3%, respectively, with RRadj: 3.4 (95% CI: 3.0–3.8). Prevalence of other gastrointestinal symptoms ranged from 70.0% vs 39.7% for bloating (RRadj: 1.8) to 8.3% vs 2.9% for nausea (RRadj: 3.0) in the Giardia and the control group, respectively. Among individuals fulfilling criteria for IBS 44% in the exposed group and 29% in the control group also fulfilled criteria for FD. IBS subtypes based on Rome III criteria (stool consistency) showed poor agreement with subtypes based on frequency of bowel movements (Kappa-values: 0.17 and 0.27).</p> <p>Conclusions & Inferences: There were high prevalences and RRs of IBS, FD and other gastrointestinal symptoms following acute giardiasis, and a high degree of overlap between the disorders. The agreement between different IBS subtype criteria varied, and there were also differences between the exposed and control group.</p>eng
dc.language.isoengeng
dc.publisherWileyeng
dc.titlePostinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasiseng
dc.typeJournal articleeng
dc.rights.holderCopyright 2016 John Wiley & Sons Ltd. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.eng
dc.type.versionacceptedVersioneng
bora.peerreviewedPeer reviewedeng
bora.journalTitleNeurogastroenterology and Motilityeng
bibo.volume28eng
bibo.issue10eng
bibo.pageStart1561eng
bibo.pageEnd1569eng
dc.identifier.cristinID1357198
dc.identifier.doi10.1111/nmo.12856eng
dc.source.issn1350-1925eng


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