Optical spectroscopy for tissue diagnostics and treatment control
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Biomedical Optics as an interdisciplinary field of science has been developed during many years and is experiencing tremendous growth, to cover a wide range of optical techniques and methods, utilized for medical therapeutic and diagnostic purposes. Biomedical optics contributes by introducing methods and creation of devices used in healthcare of various specialties, such as ophthalmology, cardiology, surgery, dermatology, oncology, radiology, etc. Each of these specialities might take advantages of different optical techniques and methods such as: laser surgery, optical thermotherapy, optical tomography and imaging, optical biopsies, photodynamic therapy, in vitro diffuse spectroscopy, etc1. Among all of the mentioned methods and techniques; photodynamic therapy, medical applications of in vitro diffuse spectroscopy, and optical biopsies, are the main topics covered by the projects presented in this book. This thesis is presented in two parts. Part one, consists of seven chapters as an introduction to the scientific works that are presented in five original papers in part two. Part one, covers areas that might not have been explicitly apparent in the papers, but have formed a basis needed to interpret data, and to understand the background for the various studied phenomena.
Paper 1: Restricted due to publisher policy. Real-time absorption and scattering characterization of slab-shaped turbid samples obtained by a combination of angular and spatially resolved measurements. Jan S. Dam, Nazila Yavari, Søren Sørensen, and Stefan Andersson-Engels. Applied Optics, Vol. 44, Issue 20, pp. 4281-4290. The published version is available at: http://dx.doi.org/10.1364/AO.44.004281Paper 2: Restricted due to publisher policy. In vitro measurements of optical properties of porcine brain using a novel compact device. N. Yavari, J. S. Dam, J. Antonsson, K. Wårdell and S. Andersson-Engels. Med. Biol. Eng. Comput., 2005, 43, 658–666. Published version is available at: http://dx.doi.org/10.1007/BF02351040Paper 3: Tissue temperature monitoring during interstitial photodynamic therapy. Jenny Svensson, Ann Johansson, Nazila Yavari, Katarina Svanberg, Stefan Andersson-Engels. Manuscript in preparation.Paper 4: Measurements of ALA-Methylester diffusivity in normal skin in vivo: A pilot study. N. Yavari, H.R. Mobini Far, N. Gustavsson, F. Torabi, C. Anderson, B. Danielsson, P.O. Larsson, K. Svanberg and S. Andersson-Engels. IFMBE Proc. 9: 176-177 (2005).Paper 5: Measurements of optical properties of pig brain tissue in vitro using a novel compact device. Nazila Yavari, Jan Sørensen Dam, Johan Antonsson, Karin Wårdell, Stefan Andersson-Engels. Copyright 2005 Society of Photo-Optical Instrumentation Engineers. This paper was published in SPIE Proc. 5864, 114-124 and is made available as an electronic reprint (preprint) with permission of SPIE. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.