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dc.contributor.authorØygarden, Halvoren_US
dc.contributor.authorFromm, Annetteen_US
dc.contributor.authorSand, Kristin Modalslien_US
dc.contributor.authorKvistad, Christopher Elnanen_US
dc.contributor.authorEide, Geir Egilen_US
dc.contributor.authorThomassen, Larsen_US
dc.contributor.authorNæss, Halvoren_US
dc.contributor.authorWaje-Andreassen, Ulrikeen_US
dc.date.accessioned2017-12-18T11:21:39Z
dc.date.available2017-12-18T11:21:39Z
dc.date.issued2016-08-09
dc.PublishedØygarden H, Fromm A, Sand KM, Kvistad CE, Eide GE, Thomassen L, Næss H, Waje-Andreassen U. A family history of stroke is associated with increased intima-media thickness in young ischemic Stroke - The norwegian stroke in the young study (NOR-SYS). PLoS ONE. 2016;11(8):e0159811eng
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/1956/17006
dc.description.abstractBackground and Purpose: Positive family history (FH+) of cardiovascular disease (CVD) is a risk factor for own CVD. We aimed to analyze the effect of different types of FH (stroke, coronary heart disease (CHD), peripheral artery disease (PAD) on carotid intima-media thickness (cIMT) in young and middle-aged ischemic stroke patients. Methods: First-degree FH of CVD was assessed in ischemic stroke patients ≤ 60y using a standardized interview. Carotid ultrasound was performed and far wall cIMT in three carotid artery segments was registered, representing the common carotid (CCA-IMT), carotid bifurcation (BIF-IMT) and the internal carotid artery (ICA-IMT). Measurements were compared between FH+ and FH negative groups and stepwise backward regression analyses were performed to identify factors associated with increased cIMT. Results: During the study period 382 patients were enrolled, of which 262 (68%) were males and 233 (61%) reported FH of CVD. Regression analyses adjusting for risk factors revealed age as the most important predictor of cIMT in all segments. The association between FH+ and cIMT was modified by age (p = 0.014) and was significant only regarding ICA-IMT. FH+ was associated with increased ICA-IMT in patients aged < 45y (p = 0.001), but not in patients ≥ 45y (p = 0.083). The association with ICA-IMT was present for a FH of stroke (p = 0.034), but not a FH+ of CHD or PAD. Conclusions: FH of stroke is associated with higher ICA-IMT in young ischemic stroke patients. Subtyping of cardiovascular FH is important to investigate heredity in young ischemic stroke patients.en_US
dc.language.isoengeng
dc.publisherPLOSeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.titleA family history of stroke is associated with increased intima-media thickness in young ischemic Stroke - The norwegian stroke in the young study (NOR-SYS)en_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2017-12-05T12:23:33Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2016 The Author(s)
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0159811
dc.identifier.cristin1392751
dc.source.journalPLoS ONE


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