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dc.contributor.authorKhan, Muhammad Tanveer
dc.contributor.authorDalvin, Sussie
dc.contributor.authorNilsen, Frank
dc.contributor.authorMale, Rune
dc.date.accessioned2017-12-19T14:21:20Z
dc.date.available2017-12-19T14:21:20Z
dc.date.issued2017-08
dc.identifier.citationKhan MT, Dalvin ST, Nilsen F, Male R. Microsomal triglyceride transfer protein in the ectoparasitic crustacean salmon louse (Lepeophtheirus salmonis). Journal of Lipid Research. 2017;58(8):1613-1623eng
dc.identifier.urihttp://hdl.handle.net/1956/17043
dc.description.abstractThe salmon louse, Lepeophtheirus salmonis, is an endemic ectoparasite on salmonid fish that is challenging for the salmon farming industry and wild fish. Salmon lice produce high numbers of offspring, necessitating sequestration of large amounts of lipids into growing oocytes as a major energy source for larvae, most probably mediated by lipoproteins. The microsomal triglyceride transfer protein (MTP) is essential for the assembly of lipoproteins. Salmon lice have three L. salmonis MTP (LsMTP) transcript variants encoding two different protein isoforms, which are predicted to contain three β-sheets (N, C, and A) and a central helical domain, similar to MTPs from other species. In adult females, the LsMTPs are differently transcribed in the sub-cuticular tissues, the intestine, the ovary, and in the mature eggs. RNA interference-mediated knockdown of LsMTP in mature females gave offspring with significantly fewer neutral lipids in their yolk and only 10–30% survival. The present study suggests the importance of LsMTP in reproduction and lipid metabolism in adult female L. salmonis, a possible metabolic bottleneck that could be exploited for the development of new anti-parasitic treatment methods.eng
dc.language.isoengeng
dc.publisherASBMBeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectlipid transport proteinseng
dc.subjectlipid transporteng
dc.subjectgene expressioneng
dc.subjectlipid and lipoprotein metabolismeng
dc.subjectlipoproteinseng
dc.subjectRNA interferenceeng
dc.subjectNile Redeng
dc.subjectOil Red Oeng
dc.subjectsea liceeng
dc.titleMicrosomal triglyceride transfer protein in the ectoparasitic crustacean salmon louse (Lepeophtheirus salmonis)eng
dc.typeJournal articleeng
dc.date.updated2017-11-27T11:56:40Z
dc.rights.holderCopyright 2017 by the American Society for Biochemistry and Molecular Biology, Inceng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1475289
dc.identifier.doi10.1194/jlr.M076430eng
dc.source.issn0022-2275eng
dc.source.issn1539-7262eng
dc.relation.projectIDNorges forskningsråd: 203513
dc.relation.projectIDNorges forskningsråd: 203513/O30
dc.relation.journalJournal of Lipid Research


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Except where otherwise noted, this item's license is described as Attribution CC BY