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dc.contributor.authorMyrum, Craig
dc.contributor.authorNikolaienko, Oleksii
dc.contributor.authorBramham, Clive R.
dc.contributor.authorHaavik, Jan
dc.contributor.authorZayats, Tetyana
dc.date.accessioned2018-02-13T14:03:45Z
dc.date.available2018-02-13T14:03:45Z
dc.date.issued2017
dc.identifier.citationMyrum C, Nikolaienko O, Bramham CRE, Haavik J, Zayats T. Implication of the APP gene in intellectual abilities. Journal of Alzheimer's Disease. 2017;59(2):723-735eng
dc.identifier.urihttp://hdl.handle.net/1956/17390
dc.description.abstract<p>Background: Cognitive functions are highly heritable and polygenic, though the source of this genetic influence is unclear. On the neurobiological level, these functions rely on effective neuroplasticity, in which the activity-regulated cytoskeleton associated protein (ARC) plays an essential role.</p> <p>Objectives: To examine whether the ARC gene complex may contribute to the genetic components of intellectual function given the crucial role of ARC in brain plasticity and memory formation.</p> <p>Methods: The ARC complex was tested for association with intelligence (IQ) in children from the Avon Longitudinal Study of Parents and Children (ALSPAC, N = 5,165). As Alzheimer&rsquo;s disease (AD) shares genetics with cognitive functioning, the association was followed up in an AD sample (17,008 cases, 37,154 controls).</p> <p>Results: The ARC complex revealed association with verbal and total IQ (empirical p = 0.027 and 0.041, respectively) in the ALSPAC. The strongest single variant signal (rs2830077; empirical p = 0.018), within the APP gene, was confirmed in the AD sample (p = 2.76E-03). Functional analyses of this variant showed its preferential binding to the transcription factor CP2.</p> <p>Discussion: This study implicates APP in childhood IQ. While follow-up studies are needed, this observation could help elucidate the etiology of disorders associated with cognitive dysfunction, such as AD.</p>eng
dc.language.isoengeng
dc.publisherIOS Presseng
dc.rightsAttribution CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.subjectAlzheimer’s diseaseeng
dc.subjectAPPeng
dc.subjectARCeng
dc.subjectAvon Longitudinal Study of Parents and Childreneng
dc.subjectdementiaeng
dc.subjectintelligenceeng
dc.subjectsynaptic plasticityeng
dc.titleImplication of the APP gene in intellectual abilitieseng
dc.typeJournal articleeng
dc.date.updated2018-01-03T20:37:36Z
dc.rights.holderCopyright 2017 IOS Press and the authorseng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1491481
dc.identifier.doi10.3233/JAD-170049eng
dc.source.issn1387-2877eng
dc.source.issn1875-8908eng
dc.relation.journalJournal of Alzheimer's Disease


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