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dc.contributor.authorHestnes, Julieen_US
dc.contributor.authorHoel, Hedda Benedicteen_US
dc.contributor.authorRisa, Ole J.en_US
dc.contributor.authorRomstøl, Hanna O.en_US
dc.contributor.authorRøksund, Ola Drangeen_US
dc.contributor.authorFrisk, Benteen_US
dc.contributor.authorThorsen, Einaren_US
dc.contributor.authorHalvorsen, Thomasen_US
dc.contributor.authorClemm, Hege Synnøve Havstaden_US
dc.date.accessioned2018-03-27T12:27:17Z
dc.date.available2018-03-27T12:27:17Z
dc.date.issued2017-07-13
dc.PublishedHestnes, Hoel HB, Risa, Romstøl, Røksund OD, Frisk BF, Thorsen E, Halvorsen T, Clemm H. Ventilatory efficiency in children and adolescents born extremely preterm. Frontiers in Physiology. 2017;8:499eng
dc.identifier.issn1664-042X
dc.identifier.urihttps://hdl.handle.net/1956/17568
dc.description.abstractPurpose: Children and adolescents born extremely preterm (EP) have lower dynamic lung volumes and gas transfer capacity than subjects born at term. Most studies also report lower aerobic capacity. We hypothesized that ventilatory efficiency was poorer and that breathing patterns differed in EP−born compared to term−born individuals. Methods: Two area−based cohorts of participants born with gestational age ≤28 weeks or birth weight ≤1000 g in 1982−85 (n = 46) and 1991–92 (n = 35) were compared with individually matched controls born at term. Mean ages were 18 and 10 years, respectively. The participants performed an incremental treadmill exercise test to peak oxygen uptake with data averaged over 20 s intervals. For each participant, the relationship between exhaled minute ventilation (V˙E) and carbon dioxide output (V˙CO2) was described by a linear model, and the relationship between tidal volume (VT) and V˙E by a quadratic model. Multivariate regression analyses were done with curve parameters as dependent variables, and the categories EP vs. term−born, sex, age, height, weight and forced expiratory volume in 1 s (FEV1) as independent variables. Results: In adjusted analyses, the slope of the V˙E−V˙CO2 relationship was significantly steeper in the EP than the term-born group, whereas no group difference was observed for the breathing pattern, which was related to FEV1 only. Conclusion: EP-born participants breathed with higher V˙E for any given CO2 output, indicating lower ventilatory efficiency, possibly contributing to lower aerobic capacity. The breathing patterns did not differ between the EP and term−born groups when adjusted for FEV1.en_US
dc.language.isoengeng
dc.publisherFrontierseng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectextremely preterm borneng
dc.subjectexerciseeng
dc.subjectbronchopulmonary dysplasiaeng
dc.subjectrespiratory mechanicseng
dc.subjectpulmonary gas exchangeeng
dc.subjectbreathing patterneng
dc.titleVentilatory efficiency in children and adolescents born extremely pretermen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2018-01-11T10:16:04Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Author(s)
dc.identifier.doihttps://doi.org/10.3389/fphys.2017.00499
dc.identifier.cristin1493318
dc.source.journalFrontiers in Physiology


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