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dc.contributor.authorBreitve, Monica Haraldseid
dc.contributor.authorChwiszczuk, Luiza
dc.contributor.authorHynninen, Kia Minna
dc.contributor.authorBrønnick, Kolbjørn Selvåg
dc.contributor.authorAuestad, Bjørn Henrik
dc.contributor.authorAarsland, Dag
dc.contributor.authorRongve, Arvid
dc.date.accessioned2018-07-31T09:38:47Z
dc.date.available2018-07-31T09:38:47Z
dc.date.issued2018-03-06
dc.identifier.citationBreitve MH, Chwiszczuk L., Hynninen KM, Brønnick KS, Auestad BH, Aarsland D, Rongve A. A Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer`s Disease. Frontiers in Neurology. 2018;9:124eng
dc.identifier.urihttp://hdl.handle.net/1956/17912
dc.description.abstract<p>Introduction: There are relatively few longitudinal studies on the differences in cognitive decline between Alzheimer&rsquo;s disease (AD) and dementia with Lewy bodies (DLB), and the majority of existing studies have suboptimal designs.</p> <p>Aim: We investigated the differences in cognitive decline in AD compared to DLB over 4 years and cognitive domain predictors of progression.</p> <p>Methods: In a longitudinal study, 266 patients with first-time diagnosis of mild dementia were included and followed annually. The patients were tested annually with neuropsychological tests and screening instruments [MMSE (Mini-Mental Status Examination), Clinical Dementia Rating (CDR), the second edition of California Verbal Learning Test (CVLT-II), Trail Making Test A &amp; B (TMT A &amp; B), Stroop test, Controlled Oral Word Associations Test (COWAT) animal naming, Boston Naming Test, Visual Object and Space Perception Battery (VOSP) Cubes and Silhouettes]. Longitudinal analyses were performed with linear mixed effects (LME) models and Cox regression. Both specific neuropsychological tests and cognitive domains were analyzed.</p> <p>Results: This study sample comprised 119 AD and 67 DLB patients. In TMT A, the DLB patients had a faster decline over 4 years than patients with AD (p = 0.013). No other longitudinal differences in specific neuropsychological tests were found. Higher executive domain scores at baseline were associated with a longer time to reach severe dementia (CDR = 3) or death for the total sample (p = 0.032). High or low visuospatial function at baseline was not found to be associated with cognitive decline (MMSE) or progression of dementia severity (CDR) over time.</p> <p>Conclusion: Over 4 years, patients with DLB had a faster decline in TMT A than patients with AD, but this should be interpreted cautiously. Beyond this, there was little support for faster decline in DLB patients neuropsychologically than in AD patients.</p>eng
dc.language.isoengeng
dc.publisherFrontierseng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0eng
dc.subjectdementia with Lewy bodieseng
dc.subjectAlzheimer’s diseaseeng
dc.subjectcognitive declineeng
dc.subjectlongitudinaleng
dc.subjectneuropsychologyeng
dc.titleA Longitudinal Study of Neurocognition in Dementia with Lewy Bodies Compared to Alzheimer`s Diseaseeng
dc.typeJournal articleeng
dc.date.updated2018-04-10T13:24:37Z
dc.rights.holderCopyright 2018 The Author(s)eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1534262
dc.identifier.doihttps://doi.org/10.3389/fneur.2018.00124eng
dc.source.issn1664-2295eng
dc.relation.journalFrontiers in Neurology


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