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dc.contributor.authorHeuch, Ingrid
dc.contributor.authorHeuch, Ivar
dc.contributor.authorHagen, Knut
dc.contributor.authorMai, Xiao-Mei
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorZwart, John-Anker
dc.date.accessioned2018-10-03T13:19:06Z
dc.date.available2018-10-03T13:19:06Z
dc.date.issued2017-11-25
dc.identifier.citationHeuch I, Heuch I, Hagen K, Mai XM, Langhammer A, Zwart J. Is there an Association between vitamin D status and risk of chronic low bak pain? A nested case-Control analysis in the Nord-Trøndelag Health Study. BMJ Open. 2017;7:e018521eng
dc.identifier.urihttp://hdl.handle.net/1956/18617
dc.description.abstract<p>Objectives: To explore potential associations between vitamin D status and risk of chronic low back pain (LBP) in a Norwegian cohort, and to investigate whether relationships depend on the season of blood sample collection.</p> <p>Design: A nested case&ndash;control study in a prospective data set.</p> <p>Setting: The Norwegian community-based Nord-Tr&oslash;ndelag Health Study (HUNT). Data were collected in the HUNT2 (1995&ndash;1997) and HUNT3 (2006&ndash;2008) surveys.</p> <p>Main outcome measure: Chronic LBP, defined as LBP persisting at least 3 months continuously during the past year.</p> <p>Participants: Among individuals aged 19&ndash;55 years without LBP in HUNT2, a data set was generated including 1685 cases with LBP in HUNT3 and 3137 controls without LBP.</p> <p>Methods: Blood samples from the participants collected in HUNT2 were analysed for serum 25-hydroxyvitamin D (25(OH)D) level. Associations with LBP in HUNT3 were evaluated by unconditional logistic regression analysis with adjustment for age, sex, work status, physical activity at work and in leisure time, education, smoking, and body mass index.</p> <p>Results: No association between vitamin D status and risk of chronic LBP was found in the total data set (OR per 10&thinsp;nmol/L 25(OH)D=1.01, 95%&thinsp;CI 0.97 to 1.06) or in individuals with blood samples collected in summer/autumn (OR per 10&thinsp;nmol/L 25(OH)D=0.99, 95%&thinsp;CI 0.93 to 1.06). For blood samples drawn in winter/spring, associations differed significantly between women and men (p=0.004). Among women a positive association was seen (OR per 10&thinsp;nmol/L 25(OH)D=1.11, 95%&thinsp;CI 1.02 to 1.20), but among men no significant association was observed (OR per 10&thinsp;nmol/L 25(OH)D=0.90, 95%&thinsp;CI 0.81 to 1.01).</p> <p>Conclusions: Overall, no association between vitamin D status and risk of LBP was demonstrated. The association suggested in women for the winter/spring season cannot be regarded as established.</p>eng
dc.language.isoengeng
dc.publisherBMJeng
dc.rightsAttribution CC BY-NCeng
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/eng
dc.titleIs there an Association between vitamin D status and risk of chronic low back pain? A nested case-Control analysis in the Nord-Trøndelag Health Studyeng
dc.typeJournal articleeng
dc.date.updated2018-07-02T05:53:41Z
dc.rights.holderCopyright 2017 The Author(s)eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1525405
dc.identifier.doi10.1136/bmjopen-2017-018521eng
dc.source.issn2044-6055eng
dc.relation.journalBMJ Open


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