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dc.contributor.authorWitt, Stephanie H.en_US
dc.contributor.authorStreit, Fen_US
dc.contributor.authorJungkunz, Men_US
dc.contributor.authorFrank, Jen_US
dc.contributor.authorAwasthi, Sen_US
dc.contributor.authorReinbold, CSen_US
dc.contributor.authorTreutlein, Jen_US
dc.contributor.authorDegenhardt, Fen_US
dc.contributor.authorForstner, AJen_US
dc.contributor.authorHeilmann-Heimbach, Sen_US
dc.contributor.authorDietl, Len_US
dc.contributor.authorSchwarze, CEen_US
dc.contributor.authorSchendel, Den_US
dc.contributor.authorStrohmaier, Janaen_US
dc.contributor.authorAbdellaoui, Aen_US
dc.contributor.authorAdolfsson, Rolfen_US
dc.contributor.authorAir, TMen_US
dc.contributor.authorAkil, Hudaen_US
dc.contributor.authorAlda, Martinen_US
dc.contributor.authorAlliey-Rodriguez, Nen_US
dc.contributor.authorAndreassen, Ole Andreasen_US
dc.contributor.authorBabadjanova, Guliaen_US
dc.contributor.authorBass, Nen_US
dc.contributor.authorBauer, Men_US
dc.contributor.authorBaune, Bernhard T.en_US
dc.contributor.authorBellivier, Franken_US
dc.contributor.authorBergen, Sarah Een_US
dc.contributor.authorBethell, Aen_US
dc.contributor.authorBiernacka, Joanna M.en_US
dc.contributor.authorBlackwood, Douglas H.R.en_US
dc.contributor.authorBoks, Marco Pen_US
dc.contributor.authorBoomsma, Dorret I.en_US
dc.contributor.authorBorglum, Anders Den_US
dc.contributor.authorBorrmann-Hassenbach, Men_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorBudde, Men_US
dc.contributor.authorButtenschon, HNen_US
dc.contributor.authorByrne, Enda M.en_US
dc.contributor.authorCervantes, Pen_US
dc.contributor.authorClarke, TKen_US
dc.contributor.authorCraddock, Nen_US
dc.contributor.authorCruceanu, Cen_US
dc.contributor.authorCurtis, Daviden_US
dc.contributor.authorCzerski, Piotr M.en_US
dc.contributor.authorDannlowski, Udoen_US
dc.contributor.authorDavis, Ten_US
dc.contributor.authorde Geus, Eco J Cen_US
dc.contributor.authorDi Florio, Aen_US
dc.contributor.authorDjurovic, Srdjanen_US
dc.contributor.authorDomenici, Enricoen_US
dc.contributor.authorEdenberg, Howard Jen_US
dc.contributor.authorEtain, Brunoen_US
dc.contributor.authorFischer, SBen_US
dc.contributor.authorForty, Len_US
dc.contributor.authorFraser, Cen_US
dc.contributor.authorFrye, Men_US
dc.contributor.authorFullerton, JMen_US
dc.contributor.authorGershon, Elliot S.en_US
dc.contributor.authorGieglin, Ien_US
dc.contributor.authorGordon, Scott Den_US
dc.contributor.authorGordon-Smith, Ken_US
dc.contributor.authorGrabe, Hans Jörgenen_US
dc.contributor.authorGreen, EKen_US
dc.contributor.authorGreenwood, TAen_US
dc.contributor.authorGrigoroiu-Serbanescu, Mariaen_US
dc.contributor.authorGuzman-Parra, Jen_US
dc.contributor.authorHall, Len_US
dc.contributor.authorHamshere, Marianen_US
dc.contributor.authorHauser, Jen_US
dc.contributor.authorHautzinger, Martinen_US
dc.contributor.authorHeilbronner, Uen_US
dc.contributor.authorHerms, Stefanen_US
dc.contributor.authorHitturlingappa, Sen_US
dc.contributor.authorHOFFMANN, PAVELen_US
dc.contributor.authorHolmans, Pen_US
dc.contributor.authorHottenga, Jouke Janen_US
dc.contributor.authorJamain, Stephaneen_US
dc.contributor.authorJones, Ien_US
dc.contributor.authorJones, Len_US
dc.contributor.authorJuréus, Annaen_US
dc.contributor.authorKahn, René Sen_US
dc.contributor.authorKammerer-Ciernioch, Juttaen_US
dc.contributor.authorKirov, Georgeen_US
dc.contributor.authorKittel-Schneider, Sarahen_US
dc.contributor.authorKloiber, Stefanen_US
dc.contributor.authorKnott, SVen_US
dc.contributor.authorKogevinas, Manolisen_US
dc.contributor.authorLanden, Men_US
dc.contributor.authorLeber, Men_US
dc.contributor.authorLeboyer, Marionen_US
dc.contributor.authorLi, Qingqin S.en_US
dc.contributor.authorLissowska, Jolantaen_US
dc.contributor.authorLucae, Susanneen_US
dc.contributor.authorMartin, NGen_US
dc.contributor.authorMayoral-Cleries, Fen_US
dc.contributor.authorMcElroy, SLen_US
dc.contributor.authorMcIntosh, Andrew Men_US
dc.contributor.authorMcKay, James Den_US
dc.contributor.authorMcQuilling, Aen_US
dc.contributor.authorMedland, Sarah Een_US
dc.contributor.authorMiddeldorp, Christel M.en_US
dc.contributor.authorMilaneschi, Yen_US
dc.contributor.authorMitchell, Philip Ben_US
dc.contributor.authorMontgomery, Grant Wen_US
dc.contributor.authorMors, Oen_US
dc.contributor.authorMühleisen, Thomas W.en_US
dc.contributor.authorMuller-Myshok, Ben_US
dc.contributor.authorMyers, Richard Men_US
dc.contributor.authorNievergelt, Caroline M.en_US
dc.contributor.authorNurnberger, John I.en_US
dc.contributor.authorO'Donovan, Michael Cen_US
dc.contributor.authorLoohuis, Loes M. Oldeen_US
dc.contributor.authorOphoff, Ren_US
dc.contributor.authorOruc, Lilianaen_US
dc.contributor.authorOwen, Michael Jen_US
dc.contributor.authorPaciga, SAen_US
dc.contributor.authorPenninx, Brenda W J Hen_US
dc.contributor.authorPerry, Aen_US
dc.contributor.authorPfennig, Andreaen_US
dc.contributor.authorPotash, James B.en_US
dc.contributor.authorPreisig, Martinen_US
dc.contributor.authorReif, Aen_US
dc.contributor.authorRivas, Fen_US
dc.contributor.authorRouleau, GAen_US
dc.contributor.authorSchofield, Peter Ren_US
dc.contributor.authorSchulze, Thomas Gen_US
dc.contributor.authorSchwarz, Men_US
dc.contributor.authorScott, Len_US
dc.contributor.authorSinnamon, GCBen_US
dc.contributor.authorStahl, Eli A.en_US
dc.contributor.authorStrauss, Jen_US
dc.contributor.authorTurecki, Gen_US
dc.contributor.authorVan der Auwera, Sen_US
dc.contributor.authorVedder, Helmuten_US
dc.contributor.authorVincent, John Ben_US
dc.contributor.authorWillemsen, Gonnekeen_US
dc.contributor.authorWitt, CCen_US
dc.contributor.authorWray, Naomi Ren_US
dc.contributor.authorXi, HSen_US
dc.contributor.authorTadic, Aen_US
dc.contributor.authorDahmen, Norberten_US
dc.contributor.authorSchott, Björn Hen_US
dc.contributor.authorCichon, Svenen_US
dc.contributor.authorNothen, Markus Men_US
dc.contributor.authorRipke, Stephanen_US
dc.contributor.authorMobascher, Aen_US
dc.contributor.authorRujescu, Danen_US
dc.contributor.authorLieb, Ken_US
dc.contributor.authorRoepke, Sen_US
dc.contributor.authorSchmal, Christineen_US
dc.contributor.authorBohus, Martinen_US
dc.contributor.authorRietschel, Marcellaen_US
dc.contributor.authorMorken, Gunnaren_US
dc.contributor.authorGade, Ken_US
dc.date.accessioned2019-02-01T17:39:53Z
dc.date.available2019-02-01T17:39:53Z
dc.date.issued2017-06-20
dc.PublishedWitt SH, Streit, Jungkunz, Frank J, Awasthi, Reinbold, Treutlein J, Degenhardt F, Forstner A, Heilmann-Heimbach, Dietl, Schwarze, Schendel D, Strohmaier J, Abdellaoui A, Adolfsson R, Air, Akil H, Alda M, Alliey-Rodriguez, Andreassen OA, Babadjanova G, Bass N, Bauer M, Baune BT, Bellivier F, Bergen SE, Bethell, Biernacka JM, Blackwood DH, Boks MP, Boomsma DI, Borglum, Borrmann-Hassenbach, Brennan P, Budde, Buttenschon, Byrne EM, Cervantes, Clarke, Craddock N, Cruceanu, Curtis D, Czerski PM, Dannlowski U, Davis T, de Geus EJC, Di Florio, Djurovic S, Domenici E, Edenberg HJ, Etain B, Fischer, Forty, Fraser C, Frye, Fullerton J, Gershon ES, Gieglin, Gordon SD, Gordon-Smith K, Grabe HJ, Green E, Greenwood T, Grigoroiu-Serbanescu M, Guzman-Parra, Hall L, Hamshere M, Hauser, Hautzinger M, Heilbronner, Herms S, Hitturlingappa, HOFFMANN P, Holmans P, Hottenga JJ, Jamain S, Jones I, Jones L, Juréus A, Kahn RS, Kammerer-Ciernioch J, Kirov G, Kittel-Schneider S, Kloiber S, Knott, Kogevinas M, Landen M, Leber, Leboyer M, Li QS, Lissowska J, Lucae S, Martin N, Mayoral-Cleries, McElroy, McIntosh AM, McKay JD, McQuilling, Medland SE, Middeldorp CM, Milaneschi Y, Mitchell PB, Montgomery GW, Mors O, Mühleisen TW, Muller-Myshok, Myers RM, Nievergelt CM, Nurnberger JI, O'Donovan MC, Loohuis LMO, Ophoff R, Oruc L, Owen MJ, Paciga S, Penninx BWJH, Perry, Pfennig A, Potash JB, Preisig M, Reif A, Rivas, Rouleau, Schofield PR, Schulze TG, Schwarz M, Scott L, Sinnamon, Stahl EA, Strauss J, Turecki, Van der Auwera, Vedder H, Vincent JB, Willemsen G, Witt C, Wray NR, Xi H, Tadic, Dahmen N, Schott BH, Cichon S, Nothen MM, Ripke S, Mobascher, Rujescu D, Lieb, Roepke, Schmal C, Bohus M, Rietschel M, Morken G, Gade. Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia. Translational psychiatry. 2017;7:e1155eng
dc.identifier.issn2158-3188
dc.identifier.urihttps://hdl.handle.net/1956/19049
dc.description.abstractBorderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipolar disorder (BIP). Up to 20% of BIP patients show comorbidity with BOR. This report describes the first case–control genome-wide association study (GWAS) of BOR, performed in one of the largest BOR patient samples worldwide. The focus of our analysis was (i) to detect genes and gene sets involved in BOR and (ii) to investigate the genetic overlap with BIP. As there is considerable genetic overlap between BIP, major depression (MDD) and schizophrenia (SCZ) and a high comorbidity of BOR and MDD, we also analyzed the genetic overlap of BOR with SCZ and MDD. GWAS, gene-based tests and gene-set analyses were performed in 998 BOR patients and 1545 controls. Linkage disequilibrium score regression was used to detect the genetic overlap between BOR and these disorders. Single marker analysis revealed no significant association after correction for multiple testing. Gene-based analysis yielded two significant genes: DPYD (P=4.42 × 10^−7) and PKP4 (P=8.67 × 10^−7); and gene-set analysis yielded a significant finding for exocytosis (GO:0006887, P_FDR=0.019; FDR, false discovery rate). Prior studies have implicated DPYD, PKP4 and exocytosis in BIP and SCZ. The most notable finding of the present study was the genetic overlap of BOR with BIP (r_g=0.28 [P=2.99 × 10^−3]), SCZ (r_g=0.34 [P=4.37 × 10^−5]) and MDD (r_g=0.57 [P=1.04 × 10^−3]). We believe our study is the first to demonstrate that BOR overlaps with BIP, MDD and SCZ on the genetic level. Whether this is confined to transdiagnostic clinical symptoms should be examined in future studies.en_US
dc.language.isoengeng
dc.publisherSpringer Natureeng
dc.relation.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5537640/
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophreniaen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2018-02-09T13:49:09Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2017 The Authors
dc.identifier.doihttps://doi.org/10.1038/tp.2017.115
dc.identifier.cristin1558577
dc.source.journalTranslational psychiatry
dc.relation.projectStiftelsen Kristian Gerhard Jebsen: SKGJ-MED-008
dc.relation.projectNorges forskningsråd: 223273


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