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dc.contributor.authorHoel, Hedda Benedicte
dc.contributor.authorHove-Skovsgaard, Malene
dc.contributor.authorHov, Johannes Espolin Roksund
dc.contributor.authorGaardbo, Julie Christine
dc.contributor.authorHolm, Kristian
dc.contributor.authorKummen, Martin
dc.contributor.authorRudi, Knut
dc.contributor.authorNwosu, Felix
dc.contributor.authorValeur, Jørgen
dc.contributor.authorGelpi, Marco
dc.contributor.authorSeljeflot, Ingebjørg
dc.contributor.authorUeland, Per Magne
dc.contributor.authorGerstoft, Jan
dc.contributor.authorUllum, Henrik
dc.contributor.authorAukrust, Pål
dc.contributor.authorNielsen, Susanne Dam
dc.contributor.authorTrøseid, Marius
dc.identifier.citationHoel HB, Hove-Skovsgaard M, Hov JR, Gaardbo JC, Holm K, Kummen M, Rudi K, Nwosu F, Valeur J, Gelpi M, Seljeflot I, Ueland PM, Gerstoft J, Ullum H, Aukrust P, Nielsen SD, Trøseid M. Impact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunction. Scientific Reports. 2018;8:6725eng
dc.description.abstractHIV infection and type 2 diabetes are associated with altered gut microbiota, chronic inflammation, and increased cardiovascular risk. We aimed to investigate the combined effect of these diseases on gut microbiota composition and related metabolites, and a potential relation to endothelial dysfunction in individuals with HIV-infection only (n = 23), diabetes only (n = 16) or both conditions (n = 21), as well as controls (n = 24). Fecal microbiota was analyzed by Illumina sequencing of the 16 S rRNA gene. Markers of endothelial dysfunction (asymmetric dimethylarginine [ADMA]), tryptophan catabolism (kynurenine/tryptophan [KT]-ratio), and inflammation (neopterin) were measured by liquid chromatography-tandem mass spectrometry. The combination of HIV and type 2 diabetes was associated with reduced gut microbiota diversity, increased plasma KT-ratio and neopterin. Microbial genes related to tryptophan metabolism correlated with KT-ratio and low alpha diversity, in particular in HIV-infected with T2D. In multivariate analyses, KT-ratio associated with ADMA (β = 4.58 [95% CI 2.53–6.63], p < 0.001), whereas microbiota composition per se was not associated with endothelial dysfunction. Our results indicate that tryptophan catabolism may be related to endothelial dysfunction, with a potentially detrimental interaction between HIV and diabetes. The potential contribution of gut microbiota and the impact for cardiovascular risk should be further explored in prospective studies powered for clinical end points.eng
dc.publisherSpringer Natureeng
dc.rightsAttribution CC BYeng
dc.titleImpact of HIV and type 2 diabetes on gut microbiota diversity, tryptophan catabolism and endothelial dysfunctioneng
dc.typeJournal articleeng
dc.rights.holderCopyright 2018 The Authorseng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.relation.journalScientific Reports

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