Show simple item record

dc.contributor.authorSolbakken, Vilde
dc.contributor.authorFismen, Anne-Siri
dc.contributor.authorBostad, Leif
dc.contributor.authorBjørneklett, Rune
dc.date.accessioned2019-02-08T17:22:28Z
dc.date.available2019-02-08T17:22:28Z
dc.date.issued2018-05-09
dc.identifier.citationSolbakken V, Fismen AS, Bostad L, Bjørneklett RO. Impact of proteinase 3 versus myeloperoxidase positivity on risk of end-stage renal disease in ANCA-associated glomerulonephritis stratified by histological classification: A population-based cohort study. Disease Markers. 2018:2018:ID 3251517eng
dc.identifier.urihttp://hdl.handle.net/1956/19086
dc.description.abstractBackground: End-stage renal disease (ESRD) risk in patients with antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis (ANCA-GN) according to ANCA serotype and stratified by histological classification has not been previously investigated. Methods: Patients from the Norwegian Kidney Biopsy Registry (NKBR) between 1991 and 2012 who had biopsy-verified pauci-immune glomerulonephritis and positive antineutrophil cytoplasmic antibody serology were included. Cases with ESRD during follow-up were identified in the Norwegian Renal Registry. ESRD-free survival with proteinase 3 (PR3) versus myeloperoxidase- (MPO-) ANCA positivity stratified into 4 histological classes was investigated. Results: Three hundred fifty-eight patients, of whom 87 progressed to ESRD during follow-up, were included. Patients with PR3- as compared to MPOANCA were younger (58 versus 64 years, p = 0 001), had a higher percentage of males (62 versus 41%, p < 0 001), had a lower percentage with a sclerozing glomerulonephritis pattern (4 versus 16%, p < 0 001), and had a significantly higher cumulative ESRD-free survival (90 versus 80%, p = 0 007) at 1-year follow-up. No significant differences in cumulative ESRD-free survival with PR3- as compared to MPO-ANCA were observed by histological stratification. Conclusion: Advanced glomerular sclerosis is found more frequently in patients with MPO-ANCA, explaining the higher risk of ESRD. ANCA serotypes have no impact on prognosis of patients with similar histological findings.eng
dc.language.isoengeng
dc.publisherHindawi Publishing Corporationeng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titleImpact of proteinase 3 versus myeloperoxidase positivity on risk of end-stage renal disease in ANCA-associated glomerulonephritis stratified by histological classification: A population-based cohort studyeng
dc.typeJournal articleeng
dc.date.updated2018-10-23T11:25:25Z
dc.rights.holderCopyright 2018 Vilde Solbakken et al.eng
dc.type.versionpublishedVersioneng
bora.peerreviewedPeer reviewedeng
dc.type.documentJournal article
dc.identifier.cristinID1622213
dc.identifier.doi10.1155/2018/3251517eng
dc.source.issn0278-0240eng
dc.source.issn1875-8630eng
dc.relation.journalDisease Markers


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution CC BY
Except where otherwise noted, this item's license is described as Attribution CC BY