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dc.contributor.authorBjørneklett, Runeen_US
dc.contributor.authorSolbakken, Vildeen_US
dc.contributor.authorBostad, Leifen_US
dc.contributor.authorFismen, Anne-Sirien_US
dc.date.accessioned2019-03-29T15:12:01Z
dc.date.available2019-03-29T15:12:01Z
dc.date.issued2018-06-03
dc.PublishedBjørneklett RO, Solbakken V, Bostad L, Fismen AS. Prognostic factors in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with severe glomerular sclerosis: a national registry-based cohort study. Pathology Research International. 2018;2018:5653612:1-7eng
dc.identifier.issn2090-8091
dc.identifier.issn2042-003X
dc.identifier.urihttps://hdl.handle.net/1956/19255
dc.description.abstractBackground. Classification of patients with anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (ANCA-GN) into histological classes is useful for predicting a patient’s risk of progression to end-stage renal disease (ESRD). However, even in the worst prognostic group, the 5-year end-stage renal disease-free survival rate is as high as 50%. Objectives. To investigate those prognostic factors indicative of progression to ESRD in patients with ANCA-GN and sclerosing histology. Methods. Patients from the Norwegian Kidney Biopsy Registry between 1991 and 2012 who had biopsy verified pauci-immune glomerulonephritis, positive ANCA serology, and sclerosing histology were included. Cases with ESRD during follow-up were identified via linkage with the Norwegian Renal Registry. Potential prognostic factors with relevant cut-offs were compared in patients with and without progression to ESRD during follow-up. Results. Of 23 included patients, 10 progressed to ESRD. ESRD patients had a lower initial estimated glomerular filtration rate (eGFR; 21 versus 52 ml/min/1.73 m2) and a lower percentage of normal glomeruli (4% versus 15%). Five-year risks of ESRD with eGFR >15 versus ≤15 ml/min/1.73 m2 were 77% and 15%, with percentage normal glomeruli >10% versus ≤10%, 83% and 39%. Conclusions. eGFR and percentage of normal glomeruli are strong risk factors for ESRD in ANCA-GN with sclerosing histology.en_US
dc.language.isoengeng
dc.publisherHindawieng
dc.rightsAttribution CC BYeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/eng
dc.titlePrognostic factors in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis with severe glomerular sclerosis: a national registry-based cohort studyen_US
dc.typePeer reviewed
dc.typeJournal article
dc.date.updated2018-11-23T11:34:57Z
dc.description.versionpublishedVersionen_US
dc.rights.holderCopyright 2018 Rune Bjørneklett et al.
dc.identifier.doihttps://doi.org/10.1155/2018/5653612
dc.identifier.cristin1631586
dc.source.journalPathology Research International


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